Search results for "BoP"
showing 10 items of 284 documents
La cute nella patologia vascolare su base organica
2012
Flebopatie e giudizio di idoneità al lavoro: descrizione di alcuni casi clinici
2010
Perspectives et bilan après 20 ans de recherche au bas de la pyramide, une étude bibliométrique pour le futur du management international
2021
Cet article propose une analyse bibliométrique du champ des stratégies au bas de la pyramide (BoP) fondée sur 364 articles citants issus de la plateforme Web of Science fournissant une base de 15 292 références. Différents outils sont mobilisés, pour mettre en évidence la structure du champ BoP d’une part, et pour identifier les tendances du front de recherche d’autre part. Six groupes structurant le champ émergent des analyses, chacun mettant en évidence un courant de recherche, et cinq tendances rythment les recherches actuelles sur le BoP. Ces analyses permettent de proposer quatre perspectives pour le futur du management international.
Bacterial growth and biological properties of Cymbopogon schoenanthus and Ziziphus lotus are modulated by extraction conditions
2020
Abstract The present study aims to evaluate the antibacterial activity and biological properties of two traditional Saharian plants (Cymbopogon schoenanthus and Ziziphus lotus). The plant extracts were obtained by using a different combination of extraction methods (conventional vs. ultrasound-assisted) and solvents (water vs. ethanol:water (50:50, v/v)). The antioxidant profile, anti-inflammatory activity and impact on bacterial growth (foodborne and probiotic bacteria) of the obtained extracts were assessed. The plant species showed the hierarchically more important role in determining the biological properties of the extracts, followed by extraction solvent and extraction conditions. Con…
Gp130-signaling synergizes with FL and TPO for the long-term expansion of cord blood progenitors
1999
We investigated the effect of a new fusion protein of IL-6 and the soluble IL-6R, H-IL-6, on the long-term ex vivo expansion of hematopoietic progenitors derived from AC133+cord blood cells. H-IL-6, which acts on both IL-6Ralpha-positive and IL-6Ralpha-negative cells, effectively synergized with FL and TPO with or without SCF for the propagation of primitive progenitors. However, IL-6 showed a greater synergistic effect with FL and TPO than H-IL-6 for long-term progenitor propagation. During the first 6 weeks of culture under stroma-free serum-containing conditions, IL-6 induced a 1.96 +/- 0.64-fold higher expansion of nucleated cells, a 2.28 +/- 0.33-fold higher expansion of CD34+ cells an…
Polish military missions in the public perception after 2001
2017
Poland since the beginning of the twenty-first century, and was involved in several military operations of great significance in the political and military for the whole world. The fight against global terrorism in Afghanistan, the implementation of the provisions allied to the US and military involvement in Iraq, the obligation to NATO allied partners from the Baltic countries are just a few of the examples of Polish military involvement on the map of global risks. How to take part in military interventions, military operations and fulfill its alliance commitments approached Polish society? This article is an attempt to approximate public sentiment towards Polish military engagement in the…
NATION-WIDE SURVEY ON THE USE OF THROMBOPOIETIN RECEPTOR AGONISTS (TPO-RA) FOR THE MANAGEMENT OF IMMUNE THROMBOCYTOPENIA IN CURRENT CLINICAL PRACTICE…
2023
Background: Two thrombopoietin receptor agonists (TPO-RA), romiplostim and eltrombopag, are currently widely adopted as second-line ITP therapy even in absence of robust evidence on their comparative advantages over rituximab or splenectomy or their preferential use in some specific clinical contexts.
 Methods: An on-line survey was distributed between May 2021 and June 2021 to collect standardized information on the use of TPO-RA in Italy.
 Results: Eighty-eight hematologists from 79 centers completed the survey. Eighty-four percent would use TPO-RA earlier than formally indicated, without a preference for young or elderly in 82% of respondents. No clear preference for either rom…
PCV5 Thromboembolisms with Thrombopoietin Receptor Agonists: Systematic Review and Meta-Analysis of Randomized Controlled Trials
2011
Second-line administration of thrombopoietin receptor agonists in immune thrombocytopenia: Italian Delphi-based consensus recommendations
2021
Introduction: In patients with primary immune thrombocytopenia (ITP), a short course of steroids is routinely given as first-line therapy. However, the response is often transient and additional therapy is usually needed. Thrombopoietin receptor agonists (TPO-RAs) are frequently used as second-line therapy, although there is little clinical guidance on the timing of their administration and on tapering/discontinuation of the drug. To provide clinical recommendations, we used the Delphi technique to obtain consensus for statements regarding administration and on tapering/discontinuation of second-line TPO-RAs among a group of Italian clinicians with expertise in management of ITP. Methods: T…
Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells.
2019
Essentials Prothrombotic extracellular vesicles (EV) carry agonist pathway-specific proteomes Agonists for protease activated receptor (PAR) 2 signaling have distinct effects on EV composition PAR2 signaling rapidly generates prothrombotic EV and slowly EV with inactive tissue factor (TF) FVIIa integrin ligation restricts TF incorporation into EV from endothelial cells SUMMARY: Background Cell injury signal-induced activation and release of tissue factor (TF) on extracellular vesicles (EVs) from immune and vessel wall cells propagate local and systemic coagulation initiation. TF trafficking and release on EVs occurs in concert with the release of cell adhesion receptors, including integrin …