Search results for "BoP"
showing 10 items of 284 documents
THE OPTIMIZATION OF INTERFERON FOR MS STUDY: 375 MICROG INTERFERON BETA-1B IN SUBOPTIMAL RESPONDERS.
2008
We aimed to evaluate the safety and MRI efficacy of interferon beta-1b (IFNbeta-1b) 375 microg (subcutaneously [sc] every other day [eod]) in relapsing-remitting multiple sclerosis (RRMS) patients with a suboptimal response to IFNbeta-1b 250 microg, i.e., with MRI activity or relapses. The OPTimization of Interferon for MS (OPTIMS) study was a prospective multicenter randomized phase 2 trial comprising a 6-month run-in phase (to identify suboptimal responders) and a 6-month randomized phase of open-label clinical and blinded MRI follow-up. During run-in all patients were treated with IFNbeta-1b 250 microg sc eod; during the study phase suboptimal treatment responders were randomized either …
The impact of del Nido cardioplegia solution on blood morphology parameters
2021
Background: Crystalloid cardioplegic solutions are believed to reduce hemoglobin significantly and increase the transfusion rate. However, recent reports indicate that the del Nido cardioplegia may preserve blood morphology parameters. Methods: In “The del Nido versus cold blood cardioplegia in aortic valve Replacement” trial patients undergoing aortic valve replacement were randomized into the del Nido (DN) or cold blood cardioplegia (CB) group. For the subanalysis, patients who underwent blood transfusions were excluded from the study. Red blood cell (RBC) count, hemoglobin, white blood cell (WBC) count and platelet (PLT) count were measured before the surgery, 24-, 48-, and 96 hours post…
Modulation of La Crosse virus infection in Aedes albopictus mosquitoes following larval exposure to coffee extracts
2013
This commentary highlights key points, basic ideas, and future outlooks presented by Eastep et al. (2012) in Frontiers in Physiology-Systems Biology. The authors have provided an interesting investigation about the successful use of an environmentally friendly product derived from plants as a larvicidal agent to control mosquito populations as well as a substance that could alter the vector competence of mosquitoes for arthropod-borne viruses (arboviruses). Specifically Eastep and collaborators used coffee extracts (with and without caffeine) to try to answer two hypothesis: first, coffee extracts could have good results as a mosquitocidal compounds applied in larval biotopes and second, vi…
Primeros hallazgos de Aedes (Stegomyia) albopictus (Skuse, 1894) en la provincia de Valencia, España
2013
First findings of Aedes (Stegomyia) albopictus (Skuse, 1894) in the province of Valencia, Spain Framed within the project "Entomological surveillance at airports and ports against vectors of imported infectious diseases, and sur- veillance of potential native vectors of these diseases", on Septem- ber 2011 Aedes albopictus (Diptera, Culicidae) is reported for the first time in the province of Valencia in the coastal municipalities of Sueca, Cullera and Gandia, using oviposition traps.
Contribution to the knowledge of the mosquitoes in the Devesa of Racó de l Olla, Albufera Natural Park of Valencia (Spain)
2017
[ES] Se presenta una recopilación de los resultados de varios proyectos, desarrollados entre los años 2004 y 2015, sobre la presencia de los mosquitos de la familia Culicidae en el entorno de la Devesa y el Racó de l¿Olla del Parque Natural de l¿Albufera de Valencia (España). Se registró un total de 10 especies pertenecientes a cinco géneros (Aedes, Coquillettidia, Culex, Culiseta y Ochlerotatus), alguno de estos muy característicos de los ambientes donde fueron recolectados. Se tratan diferentes aspectos sobre la diversidad de culícidos, así como del interés ecológico y sanitario de la presencia de los mismos. Destacamos la existencia de la especie Aedes albopictus (Skuse, 1894) en un espa…
Apoptotic effects of different drugs on cultured retinoblastoma Y79 cells
1998
This paper deals with the apoptotic effect exerted in human retinoblastoma Y79 cells by a number of compounds. A remarkable effect was observed after treatment with DNA-damaging agents, such as camptothecin, etoposide, cisplatin and carboplatin; camptothecin was found to be the most efficacious. Treatment with these compounds induced the appearance of morphological features of apoptosis in the cells together with the distinct fragmentation of DNA, as shown by agarose gel electrophoresis. These effects were also accompanied by a remarkable increase in the level of p53. Many other compounds, which are not DNA-damaging agents, induced the morphological features of apoptosis but none of them we…
Deep Vein Thrombosis
2015
Venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE). DVT occurs at an incidence of 1/1,000 and risk factors include immobilization, hospitalization, surgery, thrombophilia and positive family history, cancer, pregnancy, and other hormonal effects. Commonly, clinical signs and symptoms for DVT are unreliable, especially in hospitalized patients, but the clinical assessment of the pretest probability, for example, with the Wells score, is an important component in the diagnostic algorithm, where compression ultrasound also plays a central role. Treatment of DVT aims to acutely prevent PE and short-term and long-term VTE recurrence and to avoid the lon…
Cutaneous Lupus Erythematosus
2008
Lupus erythematosus (LE) is an inflammatory autoimmune disease, characterized by a heterogeneous clinical presentation. The skin lesions are one of the most frequent symptoms of the disease and present with a broad spectrum of LE-nonspecific and LE-specific cutaneous manifestations. Therefore, the development of a classification for skin lesions in the disease has proven difficult. For example, the LE-nonspecific cutaneous manifestations include livedo racemosa, thrombophlebitis, and leukocytoclastic vasculitis and can be associated with high disease activity and systemic organ involvement. The LE-specific cutaneous manifestations encompass the subtypes of cutaneous lupus erythematosus (CLE…
Perspectives et bilan après 20 ans de recherche et de stratégie au bas de la pyramide, une étude bibliométrique pour le futur du management internati…
2020
Conférence en ligne; International audience; Cet article propose une analyse bibliométrique du champ des stratégies au bas de la pyramide (BoP). Différents outils sont mobilisés pour analyser et comprendre la structure du champ et, plus généralement, en identifier les différentes écoles de pensée. 364 articles citant issus de la plateforme Web of Science fournissent une base de 15 292 références. Six groupes structurant le champ émergent de nos analyses, chacun mettant en évidence une spécificité des stratégies BoP. Le mapping de ce réseau de recherches permet d'envisager de nombreuses pistes de recherche et confirme l'intérêt du BoP comme axe de recherche futur du management international.
Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis
2012
The cyclic nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) regulate the activity of protein kinase A (PKA) and protein kinase G (PKG), respectively. This process helps maintain circulating platelets in a resting state. Here we studied the role of cAMP and cGMP in the regulation of megakaryocyte (MK) differentiation and platelet formation. Cultured, platelet-producing MKs were differentiated from fetal livers harvested from 13.5 days postcoital mouse embryos. MK development was accompanied by a dramatic increase in cAMP production and expression of soluble guanylate cyclase, PKG, and PKA as well as their downstream targets vasodilator-stimulated ph…