Search results for "Bottlenecks"
showing 3 items of 3 documents
Why are viral genomes so fragile? The bottleneck hypothesis
2021
If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multiple population bottlenecks experienced by viral populations at various stages of their life cycles. Modelling within-host viral populations as multi-type branching processes, we show that mutational fragility lowers the rate at which Muller’s ratchet clicks and increases the survival probability through multiple bottlenecks. In the context of a susceptible-exposed-infectious-recovered epidemiolog…
Extending the international new venture phenomenon to digital platform providers : A longitudinal case study
2018
People increasingly interact with services enabled by digital platforms. This has been a consequence of the digitalization of artifacts, which has transmuted traditional businesses into digital forms. With the increasing digitalization and modularization of services, digital platforms have given many digital service providers possibilities to scale globally, and to rapidly transcend national borders by serving multi-sided markets. However, we still know very little about how digital platform providers actually internationalize their services, or how they make their platforms available for global markets. In this paper, we contribute to the increasing literature on digital-based INVs, examin…
AQM Stability in Multiple Bottleneck Networks
2004
In this paper, we highlight that multiple bottlenecks can affect the performance of active queue management controllers, which are usually configured on a single bottleneck basis, as if each controller were the only element regulating the TCP traffic along its path. To see this, we consider a network scenario where RED is configured at each router, according to previously developed control theoretic techniques. These configuration rules assure stability in a single bottleneck scenario. Yet, we show that instability may arise when two link become congested. We justify this result through a multiple bottleneck model and give guidelines for new cooperative AQM controllers.