Search results for "Bow"
showing 10 items of 1006 documents
Comparison of Delivery Methods in Phage Therapy against Flavobacterium columnare Infections in Rainbow Trout
2021
Viruses of bacteria, bacteriophages, specifically infect their bacterial hosts with minimal effects on the surrounding microbiota. They have the potential to be used in the prevention and treatment of bacterial infections, including in the field of food production. In aquaculture settings, disease-causing bacteria are often transmitted through the water body, providing several applications for phage-based targeting of pathogens, in the rearing environment, and in the fish. We tested delivery of phages by different methods (via baths, in phage-coated material, and via oral delivery in feed) to prevent and treat Flavobacterium columnare infections in rainbow trout fry using three phages (FCOV…
Diagnostic and vaccine strategies to prevent infections in patients with inflammatory bowel disease.
2016
Summary Objectives The treatment of inflammatory bowel disease (IBD) has been revolutionized by the use of immunomodulatory agents. Although these potent drugs are effective in controlling disease activity, they also cause an increased risk of new infections or reactivation of latent infections. On these premises, we aimed to provide guidance on the definitions of immunocompromised patients, opportunistic infections and the risk factors associated with their occurrence in an IBD context, and to suggest the proper screening tests for infectious diseases and the vaccination schedules to perform before and/or during therapy with immunomodulators. Methods All the most recent evidences – filtere…
The use of phage FCL-2 as an alternative to chemotherapy against columnaris disease in aquaculture
2015
Flavobacterium columnare, the causative agent of columnaris disease in fish, causes millions of dollars of losses in the US channel catfish industry alone, not to mention aquaculture industry worldwide. Novel methods are needed for the control and treatment of bacterial diseases in aquaculture to replace traditionally used chemotherapies. A potential solution could be the use of phages, i.e., bacterial viruses, host-specific and self-enriching particles that can be can easily distributed via water flow. We examined the efficacy of phages to combat columnaris disease. A previously isolated phage, FCL-2, infecting F. columnare, was characterized by sequencing. The 47 142 bp genome of the phag…
Moc wiążąca uchwał Sądu Najwyższego in concreto w sprawach karnych
2020
Przedmiotem opracowania jest problematyka mocy wiążącej uchwał Sądu Najwyższego podejmowanych w konkretnych sprawach karnych. Podstawę prawną do podejmowania tych uchwał stanowią przepisy art. 441 k.p.k. i art. 82 ustawy z dnia 8 grudnia 2017 r. o Sądzie Najwyższym. Według art. 441 § 1 k.p.k. jeżeli przy rozpoznawaniu środka odwoławczego wyłoni się zagadnienie wymagające zasadniczej wykładni ustawy, sąd odwoławczy może odroczyć rozpoznanie sprawy i przekazać zagadnienie prawne do rozstrzygnięcia Sądowi Najwyższemu, ten zaś może również przekazać rozstrzygnięcie zagadnienia prawnego powiększonemu składowi tego sądu (arg. ex art. 441 § 2 k.p.k.). Uchwała Sądu Najwyższego jest w danej sprawi…
Mutational analysis of disulfide bonds in the trypsin-reactive subdomain of a Bowman-Birk-type inhibitor of trypsin and chymotrypsin--cooperative ver…
1998
It is widely believed that protein folding is a hierarchical process proceeding from secondary structure via subdomains and domains towards the complete tertiary structure. Accordingly, protein subdomains should behave as independent folding units. However, this prediction would underestimate the well-established structural significance of tertiary context and domain interfaces in proteins. The principal objective of this work was to distinguish between autonomous and cooperative refolding of protein subdomains by means of mutational analysis. The double-headed Bowman-Birk inhibitor of trypsin and chymotrypsin of known crystal structure was selected for study. The relative orientation of th…
Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolution…
2004
The rainbow trout (Oncorhynchus mykiss) is one of the most widely used fish species in aquaculture and physiological research. In the present paper, we report the first cloning, 3D (three-dimensional) modelling, pharmacological characterization and tissue distribution of two melanocortin (MC) receptors in rainbow trout. Phylogenetic analysis indicates that these receptors are orthologues of the human MC4 and MC5 receptors. We created 3D molecular models of these rainbow trout receptors and their human counterparts. These models suggest greater divergence between the two human receptors than between their rainbow trout counterparts. The pharmacological analyses demonstrated that ACTH (adreno…
Oral manifestations of inflammatory bowel disease
2017
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, have important extraintestinal manifestations, notably in the oral cavity. These oral manifestations can constitute important clinical clues in the diagnosis and management of IBD, and include changes at the immune and bacterial levels. Aphthous ulcers, pyostomatitis vegetans, cobblestoning and gingivitis are important oral findings frequently observed in IBD patients. Their presentations vary considerably and might be well diagnosed and distinguished from other oral lesions. Infections, drug side effects, deficiencies in some nutrients and many other diseases involved with oral manifestations should also b…
Philip Glass: Company; "Low" Symphony / Shostakovich: La nuova Babilonia (suite) / Nino Rota: La strada (suite dal balletto)
1994
L'articolo è stato realizzato in occasione della prima esecuzione italiana della "Low" Symphony di Philip Glass (Gibellina, 21 giugno 1994) e traccia un breve profilo del compositore, soffermandosi sulla genesi e i caratteri dell'opera.
A mid-IR Plasmonic Graphene Nanorectenna-based Energy Harvester to Power IoT Sensors
2022
In this paper, the design of a graphene arrow- bowtie nanoantenna mid-IR energy-harvester to power IOT wireless sensor is presented. For the first time, a sensitivity analysis of the mid-IR nanoantenna resonant frequencies in terms of different graphene number of sheets and chemical potential (μCP) without substrate and on a two-layer substrate composed of SiO2 and Si, is carried out. The obtained simulation results by 3D CST 2020 are useful to design an efficient infrared nanorectenna, composed of the nanoantenna and a rectifying MIM diode inside the gap. The analysis of the complete energy-harvester (EH), composed of an NxM nanorectenna array, a low-pass filter, and a DC-DC converter, is …
Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout.
2011
An urgent need exists to assess the exposure of fish to pharmaceuticals. The aim of the present study was to assess the uptake and metabolism of waterborne pharmaceuticals in rainbow trout (Oncorhynchus mykiss). A further objective was to determine the possibility of monitoring exposure to low levels of pharmaceuticals by bile assays. Rainbow trout were exposed for 10 d under flow-through conditions to mixtures of five pharmaceuticals (diclofenac, naproxen, ibuprofen, bisoprolol, and carbamazepine) at high and low concentrations. The low concentration was used to mimic the conditions prevailing in the vicinity of the discharge points of wastewater treatment plants. The uptake and the biocon…