Search results for "Bowel disease"

P826 Unexplained higher frequency of mutant thiopurine S-methyltransferase genotypes in inflammatory bowel disease patients of Latvia population

2019

Course of Crohn’s Disease

2015

Crohn’s disease (CD) is an inflammatory bowel disease with a chronic course and it is characterized by different events within time, which are in relation to the heterogeneity of the disease. The main events during the course of disease are activity, remission, relapse, obstruction, fistulizing, surgical resection, cancer and death. Unselected inception cohort studies are the best ones on which rely in order to avoid the selection bias from referral centers. Data produced using inception-cohort have shown a more benign course of CD than expected, an increased risk of surgery over time, with a trend which has been being reduced in the last decades, together with an increased use of biologics…

Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/drugs in colon.

2018

[EN] Mesoporous silica microparticles were prepared, loaded with the dye safranin O (M-Saf) or with the drug budesonide (M-Bud) and capped by the grafting of a bulky azo derivative. Cargo release from M-Saf at different pH values (mimicking those found in the gastrointestinal tract) in the absence or presence of sodium dithionite (a reducing agent mimicking azoreductase enzyme present in the colon) was tested. Negligible safranin O release was observed at pH 6.8 and 4.5, whereas a moderate delivery at pH 1.2 was noted and attributed to the hydrolysis of the urea bond that linked the azo derivative onto the external surface of the inorganic scaffold. Moreover, a marked release was observed w…

Impact of BMGIM Music Therapy on Emotional State in Patients with Inflammatory Bowel Disease: A Randomized Controlled Trial

2021

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2077-0383/10/8/1591 En este artículo de investigación también participan: María Josefa-Rodríguez-Morales, Ana Monzó-Gallego, José Luis Platero Armero y José Enrique de la Rubia Ortí. Este artículo pertenece al número especial "Novel Insight into the Diagnosis and Management of Crohn?s Disease". Background. Patients with inflammatory bowel disease (IBD) have a high prevalence of emotional disturbances which worsen the symptoms of the disease. As a therapeutic alternative that is part of a comprehensive care alongside medication, the Bonny Method of Guided Imagery and Music (BMGIM) music-assisted therapy has achie…

ROLE OF RENIN-ANGIOTENSIN SYSTEM IN COLONIC DYSMOTILITY ASSOCIATED WITH BOWEL INFLAMMATION IN RATS

2015

Dysregulation of different mediator systems could contribute to the gut dismotility in inflammatory bowel diseases (IBDs), chronic disorders characterized by an exasperated immune response disturbing gut functions. Among these, Angiotensin II (Ang II), the main peptide of renin-angiotensin system (RAS), can participate in inflammatory responses and RAS components are increased in IBD patients. Since RAS has emerged as gut motility regulator, our objectives was to investigate, in an IBD rat model, the RAS functionality and its eventual contribution to colonic dismotility. Experimental colitis was induced in rats by intracolonic administration of 2,4-dinitrobenzenesulfonic acid (DNBS). Drug e…

New actors in the gut :emerging players in motility and in inflammatory bowel diseae

2017

Gastrointestinal motility is an integrated process generated and modulated by local and circulating hormones and neurotransmitters which act and interact directly and indirectly on muscle cells. A plethora of regulators have been identified, but this field is continuously in expansion. Among the new actors in gut accumulating evidence strongly supports a role of renin-angiotensin system (RAS) in the digestive tract cooperating with other major mediators for maintaining gastrointestinal homeostasis. Transcripts encoding RAS components were detected in gastrointestinal tract and the involvement of RAS in gut motility modulation is increasingly emerging. The available literature demonstrated t…

Telemedicine Is an Effective Tool to Monitor Disease Activity in IBD Patients in the COVID-19 Era: A Single Centre Experience Based on Objective Data

2022

Background: The COVID-19 outbreak has led IBD clinics to adopt a remote monitoring approach in order to guarantee an adequate follow-up of patients with inflammatory bowel disease (IBD) and ensure the rules of social distancing. Aim: The aim of the study was to perform a survey on IBD patients who underwent remote monitoring in our tertiary referral center, to assess adherence, patients’ perceptions and satisfaction, and finally their opinions for future monitoring. Furthermore, we evaluated changes in disease activity and Quality of Life (QoL) using validated questionnaires. Methods: Consecutive patients with IBD scheduled for follow-up visits were switched to remote monitoring throu…

The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice

2018

The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSSinduced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compa…

Impact of Oat-Based Products on Human Gastrointestinal Tract

2015

Abstract Oat is rich in valuable nutrients. In comparison to other cereals, oat contains more total proteins, carbohydrate, fat, non-starch fibre, as well as unique antioxidants (one of them - avenanthramides), vitamins, and minerals. One of the most often studied components of oats is β-glucan - a type of soluble dietary fibre located throughout the starch endosperm, but with highest concentration in the bran. Many studies have shown the beneficial health effects of oat β-glucan as a soluble dietary fibre. Until now, most of the studies on this nutrient have been conducted in the cardiovascular and diabetology field. This article aimed to review the literature on studies that investigated …

Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

2021

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL…