Search results for "Brain"
showing 10 items of 3997 documents
Temperature controller for brain slice chambers using a current sink output stage.
1985
Response to Skeide and Friederici: The myth of the uniquely human “direct” dorsal pathway
2015
In their comment on our recent article [1], Skeide and Friederici [2] claim ‘that some important data not discussed by Bornkessel-Schlesewsky et al. strongly support the view that there are clear qualitative, and not merely quantitative, differences between [human and nonhuman primate] species with respect to both the intrinsic functional connectivity of frontal and temporal cortices, and their direct structural connection via a dorsal white matter fiber tract.’ This obviously refers to work by Friederici and colleagues [3] emphasizing the functional importance of a direct connection between the posterior superior temporal cortex (pSTC) and Brodmann area (BA) 44 in humans, and its absence i…
2020
Learning to associate written letters with speech sounds is crucial for the initial phase of acquiring reading skills. However, little is known about the cortical reorganization for supporting letter-speech sound learning, particularly the brain dynamics during the learning of grapheme-phoneme associations. In the present study, we trained 30 Finnish participants (mean age: 24.33 years, SD: 3.50 years) to associate novel foreign letters with familiar Finnish speech sounds on two consecutive days (first day ~ 50 min; second day ~ 25 min), while neural activity was measured using magnetoencephalography (MEG). Two sets of audiovisual stimuli were used for the training in which the graphe…
Modulation in alpha band activity reflects syntax composition: an MEG study of minimal syntactic binding
2021
Successful sentence comprehension requires the binding, or composition, of multiple words into larger structures to establish meaning. Using magnetoencephalography (MEG), we investigated the neural mechanisms involved in binding of language at the level of syntax, in a task in which contributions from semantics were minimized. Participants were auditorily presented with minimal sentences that required binding (pronoun and pseudo-verb with the corresponding morphological inflection; "she grushes") and wordlists that did not require binding (two pseudo-verbs; "cugged grushes"). Relative to the no binding wordlist condition, we found that syntactic binding in a minimal sentence structure was a…
2-Hydroxyoleic Acid Induces ER Stress and Autophagy in Various Human Glioma Cell Lines
2012
Background: 2-Hydroxyoleic acid is a synthetic fatty acid with potent anti-cancer activity which does not induce undesired side effects. However, the molecular and cellular mechanisms by which this compound selectively kills human glioma cancer cells without killing normal cells is not fully understood. The present study was designed to determine the molecular bases underlying the potency against 1321N1, SF-767 and U118 human glioma cell lines growth without affecting non cancer MRC-5 cells. Methodology/Principal Findings: The cellular levels of endoplasmic reticulum (ER) stress, unfolded protein response (UPR) and autophagy markers were determined by quantitative RT-PCR and immunoblotting …
FISICA QUANTISTICA E FUNZIONI MENTALI SUPERIORI III
2010
Questo saggio riprende alcuni concetti di anatomia comparata e di fisiologia, sviluppati in una mia precedente ricerca dal titolo Termodinamica, campi quantici e funzioni mentali. Il fine è di chiarire alcuni punti controversi posti dall’analisi scientifica, in riguardo a teoremi di neuro anatomia e di neurofisiologia. Il filosofo Heiddegger H. riteneva che il pensiero umano non può affidarsi interamente all’indagine scientifica, traducendo in schemi ed in formule la vivente realtà della natura, sia fisica che biologica. La ricerca scientifica si basa su un sapere rigoroso e preciso, altamente dimostrativo che può competere con la matematica, ritenuta la scienza delle scienze. Nonostante ci…
FISICA QUANTISTICA E FUNZIONI CEREBRALI SUPERIORI (II)
2010
Data una semplice perturbazione, il processo lineare tende a rimanere leggermente alterato. Data la stessa perturbazione, un processo non lineare tende a tornare al suo punto di partenza. Huygens C. (fisico olandese del XVI sec.) inventò l’orologio a pendolo e la disciplina classica della dinamica. S’imbatté in uno dei grandi esempi di questa forma di regolazione. Huygens notò che vari orologi a pendolo, appoggiati contro una parete stavano oscillando in modo perfettamente sincronizzato. Sapeva che gli orologi non potevano essere così precisi. Huygens ipotizzò che gli orologi fossero coordinati da vibrazioni trasmesse attraverso la parete. Al presente, il fenomeno è definito agganciamento d…
FISICA QUANTISTICA E FUNZIONI CEREBRALI SUPERIORI.
2010
Postnatal Neurogenesis and Neuronal Regeneration
2004
The discovery of neurogenesis in the adult brain has challenged one of the central dogmas of neuroscience. Pioneer reports in rodents seed the ground for a detailed description in birds and reptiles, which was finally confirmed in discrete regions of several mammalian species including humans. This neurogenetical capability may serve as the basis for neuronal regeneration, as has already been described in the reptilian brain, and thus may represent a promising therapeutic approach. Consequently, in the last years there has been an important effort to deepen our knowledge of the biology, the functional significance and the regulation of adult neurogenesis.
Drug-related falls and thraumatic brain injury in very old patients: antithrombotic drugs as new potential culpruit factors
2022
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