Search results for "Brea"

Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the …

2021

A water-soluble fluorescent aza-BODIPY platform (Wazaby) was prepared and functionalized by a polyazamacrocycle agent and a bioconjugable arm. The resulting fluorescent derivative was characterized and bioconjugated onto a trastuzumab monoclonal antibody as a vector. After bioconjugation, the imaging agent appeared to be stable in serum (>72 h at 37 °C) and specifically labeled HER-2-positive breast tumors slices. The bioconjugate was radiolabeled with [111In] indium and studied in vivo. The developed monomolecular multimodal imaging probe (MOMIP) is water-soluble and chemically and photochemically stable, emits in the near infrared (NIR) region (734 nm in aqueous media), and displays a goo…

A new shoreline boundary condition for a highly nonlinear 1DH Boussinesq model for breaking waves

2008

In order to model the wave motion and, in turn, the flow, within the nearshore region, in the last decades the derivation and the application of Boussinesq type of models have been extensively investigated. Nevertheless, in the framework of such depth integrated numerical models, the problems of modeling wave breaking and moving onshore boundary at the shoreline are not trivial and several approaches have been proposed to overcome these limits. In the present work an effort toward a more physical based model of the surf and the swash zone has been accomplished. In particular, starting from the work of Musumeci et al. (2005), a new model of the shoreline boundary condition has been implement…

Swash oscillation with a highly nonlinear Boussinesq model for breaking waves

2008

Run-up over variable slope bottom. Validation for a weakly nonlinear Boussinesq-type of model.

2011

A Note on Arbitration as a Means for Inadvertant Breach of Contract

2005

We focus on arbitration as a remedy for inadvertant breach of contract. We consider the effects of this procedure on precaution and reliance decisions. The model allows us to define circonstances in which arbitration is Paretosuperior to the expectation measure.

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride.

2020

Abstract In this monograph, literature data is reviewed to evaluate the feasibility of waiving in vivo bioequivalence testing and instead applying the Biopharmaceutics Classification System (BCS) based methods to the approval of immediate-release solid oral dosage forms containing moxifloxacin hydrochloride as the sole active pharmaceutical ingredient. To facilitate the feasibility decision, solubility and permeability and dissolution characteristics in the context of the BCS, therapeutic index, therapeutic use, pharmacokinetic parameters, bioequivalence/bioavailability issues, drug-excipient interactions and other relevant data were taken into consideration. Moxifloxacin is a BCS class I d…

Strengths and Weaknesses of Cancer Pain Management in Italy: Findings from a Nationwide SIAARTI Survey

2022

Objectives: Despite guidelines, a large percentage of cancer patients continue to suffer from ineffectively treated pain. The authors undertook this survey to assess the strengths and weaknesses of cancer pain management in Italy. Design: This was a prospectively administered survey. Participants: The participants were anesthesiologists of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Intervention: A 58-item questionnaire covered the demographics and features of cancer pain management in the Italian context. Results: The authors received responses from 611 pain therapists of 279 centers. Only 22% of physicians are exclusively pain therapists. Seve…

2020 Reply to: Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis …

2020

Breastfeeding and occlusal development.

2018

Data sourcesPubmed, Embase, Scopus databases and New York Academy of Medicine Grey Literature Report. There were no restrictions on language and publication dates.Study selectionTwo reviewers selected both prospective and retrospective studies of children who had either been exclusively breastfed or were mixed breastfed; who were in either the primary or mixed dentition, and malocclusion was assessed. The following malocclusion traits were included; Class 2 molar, open-bite, non-spaced dentition and posterior crossbite.Data extraction and synthesisData were extracted including type of dentition, type of malocclusion, breastfeeding data collection method, results, breast feeding malocclusion…

Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer.

2013

Recently, the ectopic expression of myoglobin (MB) was reported in human epithelial cancer cell lines and breast tumor tissues, where MB expression increased with hypoxia. The better prognosis of MB-positive breast cancer patients suggested that the globin exerts a tumor-suppressive role, possibly by impairing mitochondrial activity in hypoxic breast carcinoma cells. To better understand MB gene regulation in cancer, we systematically investigated the architecture of the human MB gene, its transcripts and promoters. In silico analysis of transcriptome data from normal human tissues and cancer cell lines, followed by RACE-PCR verification, revealed seven novel exons in the MB gene region, mo…