Search results for "Brea"
showing 10 items of 4298 documents
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
Invasive breast cancer in ectopic axillary breast tissue — case report
2021
Breast cancer is the most commonly diagnosed malignancy in women in Poland. Rare, unusual forms of breast cancer remain a diagnostic problem. The incidence of ectopic breast glandular tissue in the general population varies between 0.4 and 6%. The same abnormalities and diseases as in the anatomical mammary gland may develop in this tissue. Breast cancer may develop as well. We present the case of a 36-year-old woman, who went to the doctor because of a nodule in the right armpit presented for 2 years. The patient was referred to a surgeon with suspicion of an epidermal cyst. The lesion was surgically removed and in the histopathological examination, the diagnose was: invasive breast cancer…
A review of methods of intraoperative margin assessment in breast conserving surgery
2021
Breast conserving therapy is the primary treatment modality in early-stage breast cancer patients. Despite the development of methods for the intraoperative assessment of tumor margins, 20–30% of patients still require re-resection due to postoperative tumor infiltration at the surgery margins. In recent years, many methods have been developed to reduce the number of re-resections due to margin infiltration. Here we review the current methods together with several more techniques under investigation.
FATTORI PROGNOSTICI DELLA RECIDIVA LOCALE DOPO CHIRURGIA CONSERVATIVA PER CARCINOMA DELLA MAMMELLA. NOSTRA ESPERIENZA
1994
One of the most important problems linked to the conservative surgery of breast cancer consists of local recurrences (LR), even if it has now been proven that the appearance of LR has no influence on overal survival of the patients operated for breast cancer. We have considered 108 patients suffering from breast cancer and treated with quadrantectomy plus axillarydissection. In these patients were found 4 LR (3.7%), that in two cases appeared in the residual mammary gland and in other two cases were found on the skin scar. The mean time of occurrence of the LR was of 43 month (range 18-90 month). The authors have correlated the appearance of LR with some caracteristics of the tumor, as the …
Column Adsorption Studies for the Removal of Ammonium Using Na-Zeolite-Based Geopolymers
2022
The aim of this study was to examine the removal of ammonium ions from a synthetic model solution by using Na-zeolite-based geopolymers. Na-zeolite (=analcime) is a residue from mining industry. Three adsorbents were prepared from Na-zeolite using different production steps and metakaolin as a blending agent. These novel adsorbents were investigated in a fixed-bed column system where the effects of different flow rates with the initial ammonium concentration of 40 mg/L were studied. The Thomas, Bohart–Adams and Yoon–Nelson breakthrough curve models fitted well with the experimental data with a high R2 value. After adsorption experiments, adsorbents were regenerated using a mixture of 0.2 M …
Validating Habitual and Goal-Directed Decision-Making Performance Online in Healthy Older Adults
2021
Everyday decision-making is supported by a dual-system of control comprised of parallel goal-directed and habitual systems. Over the past decade, the two-stage Markov decision task has become popularized for its ability to dissociate between goal-directed and habitual decision-making. While a handful of studies have implemented decision-making tasks online, only one study has validated the task by comparing in-person and web-based performance on the two-stage task in children and young adults. To date, no study has validated the dissociation of goal-directed and habitual behaviors in older adults online. Here, we implemented and validated a web-based version of the two-stage Markov task usi…
Flooding in the Digital Twin Earth: The Case Study of the Enza River Levee Breach in December 2017
2023
The accurate delineation of flood hazard maps is a key element of flood risk management policy. Flood inundation models are fundamental for reproducing the boundaries of flood-prone areas, but their calibration is limited to the information available on the areas affected by inundation during observed flood events (typically fragmentary photo, video or partial surveys). In recent years, Earth Observation data have supported flood monitoring and emergency response (e.g., the Copernicus Emergency Service) thanks to the proliferation of available satellite sensors, also at high spatial resolution. Under this umbrella, the study investigates a levee breach that occurred in December 2017 along t…
Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
2022
Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…
Efficiency of COVID-19 Testing Centers in Iran: A Data Envelopment Analysis Approach
2022
AbstractObjective:The purpose of this study is to investigate the efficiency of the Iranian Red Crescent Society (IRCS) in managing their nonmonetary resources involved in coronavirus disease 2019 (COVID-19) response.Methods:For this purpose, the data envelopment analysis approach was used to measure the efficiency, considering the number of personnel and vehicles and screened passengers as the input and output parameters, respectively. It was examined the efficiency of 10 IRCS’s branches given 17 d of screening operation. For the analysis, the DEA SolverPro software 15a version was used.Results:The results show that only 1 branch had been fully efficient in using the resources, while 5 bra…