Search results for "Brucellosis"

showing 10 items of 17 documents

Abnormal liver function in brucellosis

2008

We assessed the prevalence of impaired liver function in 47 patients suffering from brucellosis consecutively admitted to our department over the last five years. Parameters of liver function and ultrasound of the upper abdomen were performed at entry and at the end of treatment. On admission, mean transaminase values were elevated and significantly higher than at recovery (p 0.001): 38 percent and 53 percent of patients had elevated baseline values of GOT and GPT vs 13 and 19% at the end of treatment, respectively. Mean serum values of alkaline phosphatase (AP) were within normal limits on admission, although in 12 of them serum values were elevated. The same proportion was seen for gamma-…

brucellosis infection disease liver function
researchProduct

Treatment of human brucellosis with rifampin plus minocycline

2003

In order to evaluate the efficacy and tolerability of a high intravenous dose of rifampin plus oral minocycline (administered daily for 3 weeks) for the treatment of acute brucellosis, we retrospectively reviewed the outcome of 239 consecutive patients (135 adults and 104 children) diagnosed and treated over a 17-year period in Italy. The combination used resulted in 100% response and a relapse rate lower than 2%. Fifty-two (30 adults and 22 children) (29.8%) complained of mild adverse effects including an increase in aspartate aminotransferase (>250 IU) observed in 12 cases and considered related to rifampin and in 11 cases a reversible hyperpigmentation of the tongue attributed to minocyc…

AdultMalemedicine.medical_specialtyAdolescentmedicine.medical_treatmentMinocyclineRisk AssessmentDrug Administration SchedulePharmacotherapyRecurrenceInternal medicinemedicineHumansPharmacology (medical)ChildInfusions IntravenousAdverse effectAgedRetrospective StudiesAntibacterial agentAged 80 and overPharmacologyChemotherapyDose-Response Relationship Drugbusiness.industryRetrospective cohort studyMinocyclineMiddle AgedBrucellaSurgeryTreatment OutcomeInfectious DiseasesItalyOncologyTolerabilityChild PreschoolbrucellosisDrug Therapy CombinationFemaleRifampinbusinessRifampicinFollow-Up Studiesmedicine.drug
researchProduct

Changing epidemiology of human brucellosis, Germany, 1962-2005

2007

This endemic occupational disease has become a foodborne and travel-associated zoonosis primarily affecting Turkish immigrants.

trendsAdultMaleMicrobiology (medical)Pediatricsmedicine.medical_specialtyTime FactorsAdolescentEpidemiologyOccupational diseaselcsh:MedicineRate ratioBrucellosislcsh:Infectious and parasitic diseasesGermanyEnvironmental healthCase fatality rateEpidemiologymedicineHumanslcsh:RC109-216ChildTurkish immigrantsAgedHuman brucellosisbusiness.industryResearchIncidenceIncidence (epidemiology)Public healthlcsh:RZoonosisInfant NewbornInfantBrucellosisMiddle Agedmedicine.diseaseInfectious DiseasesChild Preschoolpopulation characteristicsFemalebusinesshuman activities
researchProduct

Use of sulesomab in the diagnosis of brucellar spondylitis.

2004

ABSTRACT Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a 99m Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases. The sensitivity and specificity of leukoscintigraphy were 27.2% and 81.1%, respectively. Based on these results,…

Microbiology (medical)AdultMalePathologymedicine.medical_specialtyAnticorps monoclonalBrucellosis; LeukoScan; leukoscintigraphy; spondylitis; SulesomabSensitivity and SpecificityBrucellosisleukoscintigraphyAntibodies Monoclonal Murine-DerivedBrucellosiLeukocytesMedicineHumansRadionuclide ImagingSpondylitisAgedAged 80 and overmedicine.diagnostic_testbusiness.industryAntibodies MonoclonalMagnetic resonance imagingBrucellosisGeneral MedicineMiddle Agedmedicine.diseaseMagnetic Resonance ImagingInfectious DiseasesDiagnostic agentspondylitiFemaleLeukoScanbusinessNuclear medicineSulesomabSpondylitisClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
researchProduct

Monocyte and lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in clinical management.

2003

This study evaluated the level of susceptibility of monocytes and lymphocytes to spontaneously induced and CH11-induced apoptosis in 16 patients with Brucella infection. The expression of some immunological and apoptotic markers was evaluated. Before therapy, monocytes showed a high level of resistance to spontaneously induced or CH11-induced apoptosis in all patients. In patients with acute infection, this resistance persisted for 10-20 days after treatment was initiated, then decreased; in chronically infected patients, it persisted after 45 days of treatment. Lymphocytes were also more resistant to CH 11-induced apoptosis. The level of activated CD8++ T lymphocytes was high in patients w…

Microbiology (medical)AdultAdolescentLymphocyteApoptosisBrucellaCD8-Positive T-LymphocytesMonocyteBrucellosisMonocytesBrucellosimedicineHumansLymphocytesfas ReceptorChildbiologybusiness.industryMonocyteAntibodies MonoclonalBrucellosisCD8-Positive T-LymphocyteT lymphocytebiology.organism_classificationmedicine.diseaseBrucellaInfectious Diseasesmedicine.anatomical_structureApoptosisChild PreschoolImmunologyAcute DiseaseChronic Diseasebiology.proteinLymphocyteAntibodybusinessCD8Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
researchProduct

No findings of dental defects in children treated with minocycline

2004

Thanks to their broad antimicrobial spectrum, tetracyclines were found to be valuable for the treatment of many infections (10). Unfortunately, they irreversibly bind to calcifying tissues and are deposited along the incremental lines of dentine and enamel, causing defects and staining, from bright yellow to dark brown (3, 5, 8). According to the American Academy of Pediatrics, tetracyclines are not indicated for the treatment of common infections in children younger than 8 years of age. However, doxycycline (a tetracycline analogue) is recommended for treatment of Rocky Mountain spotted fever in children of any age (1). Minocycline has several advantages over other tetracyclines: it is bet…

PopulationDentistryMinocyclineClinical TherapeuticsBrucellosisMedicineHumansPharmacology (medical)educationChildDental EnamelAntibiotics AntitubercularAntibacterial agentRetrospective StudiesPharmacologyeducation.field_of_studyEnamel paintDentitionbusiness.industryRetrospective cohort studyOdds ratiomedicine.diseasehumanitiesAnti-Bacterial Agentsstomatognathic diseasesInfectious DiseasesTooth Diseasesvisual_artRelative riskChild Preschoolvisual_art.visual_art_mediumRifampinbusinessDental fluorosis
researchProduct

Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations

2007

Policy Forum. Competing interests: ER has received research grants from Daiichi, Bayer, and Theravance and has served as a consultant to Pfizer, Theravance, Bayer, Wyeth, Rosetta, and BiondVax. Summary Points Brucellosis remains the commonest anthropozoonosis worldwide, and its treatment remains complex, requiring protracted administration of more than one antibiotic. In November 2006, a consensus meeting aimed at reaching a common specialist statement on the treatment of brucellosis was held in Ioannina, Greece under the auspices of the International Society of Chemotherapy and the Institute of Continuing Medical Education of Ioannina. The author panel suggests that the optimal treatment o…

:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings]Veterinary medicine:Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Streptomycin [Medical Subject Headings]:Phenomena and Processes::Microbiological Phenomena::Drug Resistance Microbial [Medical Subject Headings]DiseaseGlobal Health:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Health Care::Population Characteristics::Health::World Health [Medical Subject Headings]Terminología como AsuntoBrucellosi:Organisms::Eukaryota::Animals [Medical Subject Headings]:Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization [Medical Subject Headings]Policy ForumMedicine in Developing CountriesGentamicinasDrug Resistance MicrobialBrucelosisAdhesión a DirectrizGeneral MedicineHumanosDrug CombinationsAntibacterianosDoxycyclineStreptomycinEstreptomicinaMedicine:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds with 4 or More Rings::Rifamycins::Rifampin [Medical Subject Headings]Drug Therapy CombinationGuideline AdherenceRifampinFluoroquinolonesSalud Mundialmedicine.medical_specialtyEfficacyResultado del TratamientoInvestigación BiomédicaRecurrenciaTherapeuticsWorld Health OrganizationMicrobiologyAntibiotic resistanceTerminology as Topic:Disciplines and Occupations::Social Sciences::Internationality::International Cooperation::Developing Countries [Medical Subject Headings]HumansMedical journalIntensive care medicineDeveloping Countries:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Pyrimidines::Trimethoprim::Trimethoprim-Sulfamethoxazole Combination [Medical Subject Headings]medicine.diseaseCotrimoxazoleAnimalesQuimioterapia:Humanities::Humanities::History::History Modern 1601-::History 21st Century [Medical Subject Headings]GentamicinsBrucel·losiBiomedical ResearchCommunicable diseases:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 2-Ring::Quinolines::Quinolones::Fluoroquinolones [Medical Subject Headings]Human diseaseRecurrence:Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations [Medical Subject Headings]:Information Science::Information Science::Communication::Language::Linguistics::Terminology as Topic [Medical Subject Headings]biologyIraqi patientsRMetaanalysis:Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Brucellosis [Medical Subject Headings]Historia del Siglo XXIAnti-Bacterial AgentsCombinación Trimetoprim-SulfametoxazolTreatment OutcomeInfectious Diseases:Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Polycyclic Hydrocarbons Aromatic::Naphthacenes::Tetracyclines::Doxycycline [Medical Subject Headings]Fluoroquinolonas:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings]:Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins [Medical Subject Headings]Países en Desarrollo:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy Combination [Medical Subject Headings]BrucellaHistory 21st CenturyBrucellosisWorld healthTrimethoprim Sulfamethoxazole Drug CombinationmedicineAnimals:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Resistencia a Medicamentosbusiness.industryOrganización Mundial de la SaludBrucellosisMalalties infecciosesTerapèuticabiology.organism_classificationCombinación de MedicamentosDoxiciclinaTherapybusinessBrucella melitensisPLoS Medicine
researchProduct

Denitrification in pathogenic bacteria : for better or worst ?

2005

A large variety of physiological and taxonomic groups have the ability to use nitrogen oxides as alternative electron acceptors. Brucella spp. is an alpha-proteobacteriaceae that induces a persistent disease in some mammals. Recent work has revealed that a denitrifying gene cluster is important in the interaction of Brucella neotomoae with its host.

Microbiology (medical)Nitrite ReductasesDenitrification[SDV]Life Sciences [q-bio]Brucellamedicine.disease_causeMicrobiologyBrucellosisMicrobiologyMiceDenitrifying bacteriaNitrate Reductasesdenitrifying geneVirologyGene clustermedicineAnimalsNitrogen oxidesRELATION HOTE-PARASITEVirulencebiologyHost (biology)Brucella speciesbactérie dénitrifiantePathogenic bacteriabiology.organism_classificationBrucellaPersistent Diseasenitrogen oxidesInfectious Diseases[SDE]Environmental SciencesOxidoreductases
researchProduct

Involvement of the aorta in brucellosis: the forgotten, life-threatening complication. A systematic review.

2012

Abstract Human brucellosis is a disease of protean manifestations, and has been implicated in complications and focal disease in many human organ systems. However, little is collectively known about the background, the course, the clinical characteristics, the diagnostic issues raised, and the short- and long-term therapeutic approaches in patients with aortic involvement as a complication of brucellosis. With the aim to glean from the literature useful information to better understand and manage this complication, a computerized search without language restriction was conducted using PubMed and SCOPUS. An article was considered eligible for inclusion in the systematic review if it reported…

Spondylodiscitismedicine.medical_specialtyDiscitisAortic RuptureDiseaseMicrobiologyBrucellosisBrucellosis; aortaDiagnosis DifferentialBrucellosiRisk FactorsVirologymedicine.arterymedicineThoracic aortaEndocarditisHumansIntensive care medicineAortaAortabusiness.industryAbdominal aortaBrucellosismedicine.diseaseBrucellaSurgeryAortic AneurysmInfectious DiseasesbusinessComplicationVector borne and zoonotic diseases (Larchmont, N.Y.)
researchProduct

Urticaria and bacterial infections

2014

The association between urticaria and infectious diseases has been discussed for >100 years. However, a causal relationship with underlying or precipitating infection is difficult to establish. The purpose of this work was to perform a systematic analysis of the published cases of urticaria associated with bacterial infections. We give an umbrella breakdown of up-to-date systematic reviews and other important publications on the complex association of urticaria and bacterial infections. We did a Medline search, for English language articles published until January 2014, using the key words "urticaria" and "bacteria/bacterial disease"; a second analysis was performed in groups of bacteria an…

Pulmonary and Respiratory MedicineUrticariaPATHOGENESISCHILDRENBrucellaLyme diseaseANGIOEDEMAimmune system diseasesHELICOBACTER-PYLORIMYCOPLASMA-PNEUMONIAE INFECTION; HELICOBACTER-PYLORI; LYME-DISEASE; ANGIOEDEMA; CHILDREN; BRUCELLOSIS; VASCULITIS; MANIFESTATIONS; PATHOGENESIS; EOSINOPHILIAparasitic diseasesHumansImmunology and AllergyMedicineVASCULITISskin and connective tissue diseasesBRUCELLOSISBacterial diseaseChlamydiaEOSINOPHILIAAngioedemabiologybusiness.industryLYME-DISEASEBacterial InfectionsGeneral MedicineHelicobacter pylorimedicine.diseasebiology.organism_classificationMANIFESTATIONSMycoplasma pneumoniaImmunologyMYCOPLASMA-PNEUMONIAE INFECTIONmedicine.symptombusinessPneumonia (non-human)
researchProduct