Search results for "Bull"
showing 10 items of 345 documents
On the Bullwhip Avoidance Phase: The Synchronised Supply Chain
2012
Abstract The aim of this paper is to analyse the operational response of a Synchronised Supply Chain (SSC). To do so, first a new mathematical model of a SSC is presented. An exhaustive Latin Square design of experiments is adopted in order to perform a boundary variation analysis of the main three parameters of the periodic review smoothing ( S , R ) order-up-to policy: i.e., lead time, demand smoothing forecasting factor, and proportional controller of the replenishment rule. The model is then evaluated under a variety of performance measures based on internal process benefits and customer benefits. The main results of the analysis are: (I) SSC responds to violent changes in demand by re…
The effect of inventory record inaccuracy in information exchange supply chains
2015
Abstract The goal of this paper is to quantify the impact of Inventory Record Inaccuracy on the dynamics of collaborative supply chains, both in terms of operational performance (i.e. order and inventory stability), and customer service level. To do so, we model an Information Exchange Supply Chain under shrinkage errors in the inventory item recording activity of their nodes, present the mathematical formulation of such supply chain model, and conduct a numerical simulation assuming different levels of errors. Results clearly show that Inventory Record Inaccuracy strongly compromises supply chain stability, particularly when moving upwards in the supply chain. Important managerial insights…
Interpersonal difficulties in obesity: A systematic review and meta-analysis to inform a rejection sensitivity-based model
2019
Abstract Obesity is associated with difficulties due to stigma and loneliness. These impact negatively on individuals’ quality of life and behaviour change efforts. Increased sensitivity to others’ negative feedback might play a role in the maintenance of these difficulties and could be addressed in psychological interventions. We conducted a systematic review of interpersonal difficulties in individuals with obesity, across the lifespan. We investigated early interpersonal adversity (i.e. frequency of teasing/bullying), perceived interpersonal stress and quality of social life, based on a rejection sensitivity model. The databases PubMed, Web of Knowledge and AGRIS, Embase, Medline and Psy…
On the Bullwhip Avoidance Phase: supply chain collaboration and order smoothing
2009
This paper provides an assessment of the impact of collaboration and smoothing replenishment rules on supply chain operational performance and customer service level. Three supply chain configurations (i.e. Traditional, Information Exchange and Synchronised) in which orders are generated by smoothing (S, R) inventory control policies are studied for different proportional controllers. A supply chain stress test is performed through a sudden and intense change in demand. A structured and extended supply chain assessment framework is adopted. The main conclusions of this paper are the following. (i) The impact of Supply Chain Collaboration on overall supply chain performance is greater than t…
Inventory policies and information sharing in multi-echelon supply chains
2011
The aim of this article is to show how to modify a replenishment rule in relation to the operational information shared by suppliers. More specifically, we present a model of an Automatic Pipeline Variable Inventory and Order-Based Production Control System rule for a multi-echelon supply chain characterised by different increasing levels of shared information. A numerical study is presented to underline the performance differences for three variants of the smoothing order rule in terms of bullwhip reduction, inventory stability and operational and customer responsiveness. Results show how the effectiveness of a smoothing replenishment rule depends on the level of information sharing.
Production Inventory and Enterprise System Implementation: An Ex-ante No-Cost Based Evaluation
2010
The objective of this paper is to present an Enterprise System (ES) ex-ante no-cost based three step evaluation technique, which enables a pre-emptive analysis of the effects of an ES implementation using a system of referenced non financial performance metrics. The innovativeness is in the use of a simulation model fully integrated with the evaluation procedure. Researchers can extend the presented technique to further modelling approaches and test it on different market sectors. The analysis provides practitioners with a measurement system that enables an analysis of the effects of a given ES implementation and can be further employed in financial evaluations.
Mobbing, Bullying und andere Aggressionen unter Schülern als Quelle von Schulstress: Inwieweit sind die "Opfer" daran beteiligt?
2008
Schulstress kommt in erheblichem Maße auch durch aggressive Interaktionen zwischen Schülern zustande. Aggressionen in der Schule können vielfältige Formen annehmen und verschiedene Ursachen haben. In diesem Beitrag geht es um Bullying, Mobbing und relationale Aggression unter Schülern. Wichtige Forschungsbefunde zu den verschiedenen Aggressionsformen werden dargestellt. Anschließend wird eine psychoanalytische Behandlung einer Jugendlichen wegen Mobbing vorgestellt. Die Therapie erstreckte sich über 70 Stunden und umfasste auch begleitende Elterngespräche. Der Behandlungsverlauf verdeutlicht, dass es wichtig ist, die eigene Beteiligung der Schülerinnen und Schüler am Auslösen und Aufrechter…
Ectopic expression of desmin in the epidermis of transgenic mice permits development of a normal epidermis.
2002
Cell architecture is largely based on the interaction of cytoskeletal proteins, which include intermediate filaments (IF), microfilaments, microtubules, as well as their type-specific membrane-attachment structures and associated proteins. In order to further our understanding of IF proteins and to address the fundamental issue whether different IF perform unique functions in different tissues, we expressed a desmin transgene in the basal epidermis of mice. Ectopic expression of desmin led to the formation of an additional, keratin-independent IF cytoskeleton and did not interfere with the keratin-desmosome interaction. We show that ectopic expression of a type III IF protein in basal kerat…
Epidermolysis Bullosa Simplex-Type Mutations Alter the Dynamics of the Keratin Cytoskeleton and Reveal a Contribution of Actin to the Transport of Ke…
2003
Dominant keratin mutations cause epidermolysis bullosa simplex by transforming keratin (K) filaments into aggregates. As a first step toward understanding the properties of mutant keratins in vivo, we stably transfected epithelial cells with an enhanced yellow fluorescent protein-tagged K14R125C mutant. K14R125C became localized as aggregates in the cell periphery and incorporated into perinuclear keratin filaments. Unexpectedly, keratin aggregates were in dynamic equilibrium with soluble subunits at a half-life time of <15 min, whereas filaments were extremely static. Therefore, this dominant-negative mutation acts by altering cytoskeletal dynamics and solubility. Unlike previously post…
English as a Tool to Prevent Bullying and Encourage Equalities: The KiVa Project
2018
Through the combination of the KiVa project and the English language beyond its formal academic aspects, this work aims to achieve an efficient antibullying program that fits the students’ needs. The main objective of this research is to prevent bullying, to encourage equalities and to ensure that bullying victims can count on the support of the class group to feel more confident about themselves and to not be afraid. To carry out all this, we suggest using English as students’ L2 in order that it serves as a tool to prevent bullying. Moreover, English is chosen as the subject since it is a neutral common language for all the students, and leads to an environment of equality in the classroo…