Search results for "Butorphanol"

showing 3 items of 3 documents

Genetic evolution of T-cell resistance in the course of melanoma progression

2014

Abstract Purpose: CD8+ T lymphocytes can kill autologous melanoma cells, but their activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of disease progression. Here, we analyzed three consecutive melanoma lesions obtained within one year of developing stage IV disease for their recognition by autologous T cells. Experimental Design: One skin (Ma-Mel-48a) and two lymph node (Ma-Mel-48b, Ma-Mel-48c) metastases were analyzed for T-cell infiltration. Melanoma cell lines established from the respective lesions were characterized, determining the T-cell–stimulatory capacity, expression of surface molecules involved in T-cell activation, and specific genetic alteratio…

Cancer ResearchB7 Antigensmedicine.medical_treatmentMedizinGene ExpressionT-Lymphocyte Subsetshemic and lymphatic diseasesCluster AnalysisLymphocytesNeoplasm MetastasisLymph nodeMelanomaTumorImmunogenicityMelanomaSingle Nucleotidemedicine.anatomical_structurePhenotypeButorphanolOncologyDisease ProgressionCytokinesEvolutionT cellHuman leukocyte antigenBiologyPolymorphism Single NucleotideArticleCell LineEvolution MolecularLymphocytes Tumor-InfiltratingCell Line TumormedicineHumansGenetic Predisposition to DiseaseTumor-InfiltratingAllelePolymorphismneoplasmsAllelesNeoplasm StagingHistocompatibility Antigens Class IMolecularImmunotherapymedicine.diseaseAlleles; B7 Antigens; Butorphanol; Cell Line Tumor; Cluster Analysis; Cytokines; Disease Progression; Gene Expression; Genetic Predisposition to Disease; Histocompatibility Antigens Class I; Humans; Lymphocytes Tumor-Infiltrating; Melanoma; Mutation; Neoplasm Metastasis; Neoplasm Staging; Phenotype; Polymorphism Single Nucleotide; T-Lymphocyte Subsets; beta 2-Microglobulin; Evolution Molecular; Oncology; Cancer ResearchImmunologyMutationbeta 2-MicroglobulinCD8
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Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor …

2020

Although theta-burst stimulation (TBS) is known to differentially modify motor cortical excitability according to stimulus conditions in humans, whether similar effects can be seen in animals, in particular rats, remains to be defined. Given the importance of experimental rat models for humans, this study explored this stimulation paradigm in rats. Specifically, this study aimed to explore corticospinal excitability after TBS in anesthetized animals to confirm its comparability with human results. Both inhibition-facilitation configurations using paired electrical stimulation protocols and the effects of the TBS paradigm on motor-evoked potentials (MEPs) in rat descending motor pathways wer…

Xylazine0301 basic medicinecorticospinal tractintracortical inhibitionMidazolamCognitive NeurosciencePyramidal TractsNeuroscience (miscellaneous)StimulationStimulus (physiology)lcsh:RC321-57103 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineAnimalsHypnotics and SedativesMedicineKetamineelectrical stimulationlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryOriginal Researchtheta burst stimulationbusiness.industryInterstimulus intervalMotor CortexNeural InhibitionMedetomidineEvoked Potentials MotorMedetomidineElectric StimulationSensory SystemsRats030104 developmental biologymedicine.anatomical_structureButorphanolModels AnimalCorticospinal tractFacilitationKetaminebusinessNeuroscience030217 neurology & neurosurgerymotor-evoked potentialsintracortical facilitationNeuroscienceMotor cortexmedicine.drugFrontiers in Neural Circuits
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THU0413 New Formulation with Potential for the Prevention and Treatment of Osteoporosis and Osteoarthritis

2013

Background Osteoarthritis (OA) is a multidimensional disease that affects all anatomical joint structures, particularly cartilage, synovium and subchondral bone. In turn, osteoporosis (OP) is a skeletal disorder characterized by a compromised bone strength which substantially increases the risk of fracture. Both are common disorders which affect quality of life in elderly. Despite this, there is not any drug at the moment for the simultaneous prevention and treatment of osteoporosis and osteoarthritis. Objectives The aim of this study was to investigate the effect of a new formulation in a combined rat model of OP and OA. The formulation (BIS076) contains Vitamin D3, Hydroxyapatite as a sou…

medicine.medical_specialtybusiness.industryButorphanolCartilageImmunologyOsteoporosisUrologyOsteoarthritismedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologySurgerySubcutaneous injectionmedicine.anatomical_structureRheumatologySkeletal disorderSynovitisOvariectomized ratImmunology and AllergyMedicinebusinessmedicine.drugAnnals of the Rheumatic Diseases
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