Search results for "C-H"

showing 10 items of 82 documents

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.

2014

Item does not contain fulltext Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of common and rare variants in more than 30 genes, as quantified by genetic risk scores. Rare autosomal recessive monogenic hypertriglyceridaemia can result from large-effect mutations in six different genes. Hypertriglyceridaemia is exacerbated by non-genetic factors. On the basis of recent genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/L), which is more likely to have a mono…

Multifactorial InheritanceSettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismVascular damage Radboud Institute for Health Sciences [Radboudumc 16]Genome-wide association studyDisease030204 cardiovascular system & hematologyISCHEMIC-HEART-DISEASEBioinformaticshypertriglyceridaemia0302 clinical medicineEndocrinologyGENERAL-POPULATIONHypertriglyceridemiatreatmentmedicine.diagnostic_testREMNANT CHOLESTEROLCombined Modality Therapy3. Good healthLIPASE DEFICIENCYdiagnosiPLASMA TRIGLYCERIDESDENSITY-LIPOPROTEIN CHOLESTEROLCARDIOVASCULAR-DISEASEPractice Guidelines as TopicBiomarker (medicine)Multifactorial Inheritancemedicine.medical_specialty030209 endocrinology & metabolismHealth PromotionArticle03 medical and health sciencesPharmacotherapyInternal medicineInternal MedicinemedicineAnimalsHumansHOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIAGenetic Predisposition to DiseaseAlleleGENOME-WIDE ASSOCIATIONLife Stylehypertriglyceridaemia; diagnosis; treatmentTriglyceridesGenetic testingbusiness.industryHypertriglyceridemianutritional and metabolic diseasesmedicine.diseaseEndocrinologyNONFASTING TRIGLYCERIDESbusinessBiomarkersThe lancet. Diabetesendocrinology
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Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils

2019

The quality of extra virgin olive oils is affected mainly by hydrolytic and oxidative reactions. The present paper investigated the changes of major and minor components and oxidation indices of three monovarietal extra virgin olive oils after 18 months of storage at room temperature and in dark glass bottles conditions. After storage, the basic quality parameters such as free acidity, peroxide values, extinction coefficients, fatty acids composition, chlorophyll and carotenoid content, did not exceed the upper limits set by European Community Regulations for extra-virgin olive oils. Given the importance of the phenolic fraction, UHPLC-HESI-MS metodology was used. A decrease in 3,4-DHPEA-ED…

OleacinIridoid GlucosidesUHPLC-HESIMSFraction (chemistry)Plant Science01 natural sciencesBiochemistryPeroxideAnalytical Chemistrychemistry.chemical_compoundHydrolysisUHPLC-HESI-MSGlucosidesPhenolsOleuropeinFood QualityIridoidsFood scienceOlive OilCarotenoidPyranschemistry.chemical_classification010405 organic chemistryFatty AcidsOrganic Chemistry0104 chemical sciencesTyrosol010404 medicinal & biomolecular chemistryFood StorageItalychemistryoleochantalChlorophyllHydroxytyrosoloil agingOxidation-ReductionhydroxytyrosolNatural Product Research
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Homogeneous Metal-Based Catalysis in Supercritical Carbon Dioxide as Reaction Medium

2016

Above 31.1 degrees C and 73.8 bar, carbon dioxide reaches the supercritical state, being transformed into a fluid (scCO(2)) that has attracted interest in the last few decades as reaction medium for several transition-metal-catalyzed organic transformations. The main feature of this fluid rests on its capability to dissolve large amounts of other gases such as hydrogen, carbon monoxide, ethylene, or even methane and light alkanes. In this manner, very high concentrations of these reactants are available for catalysis. In this contribution a review of the main achievements of the use of transition-metal complexes as catalysts in scCO(2) is presented.

Olefin metathesisInorganic chemistryHomogeneous catalysis010402 general chemistry01 natural sciencesC-C bond formationCatalysisMethaneCatalysischemistry.chemical_compoundSupercritical carbon dioxideOxidationC-H activationCycloadditionElectrochemical reduction of carbon dioxideSupercritical carbon dioxide010405 organic chemistryChemistryGeneral ChemistryHomogeneous catalysisSupercritical fluid0104 chemical sciencesCarbon dioxideHydroformylationHydrogenationCarbon monoxide
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A new By-Product enriched in phenolic compounds, evaluated by UHPLC-HRMS, from olive mill wastewater

Olive mill wastewaterby-productUHPLC-HRMShydroxytyrosol
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Petrographic and geochemical characterization of Archaic-Hellenistic tableware production at Solunto, Sicily

2009

A selected assortment of Archaic-Hellenistic tableware samples from Solunto, a Phoenician-Punic site located 20 km east of Palermo (Sicily), has been subjected to thin-section petrography and chemical analysis (XRF). In this settlement several ceramic kilns remained operative over a long time period (7th to 3rd century B.C.). The main goal of this analytical study is to distinguish the ceramics manufactured locally from regional and off-island imports. Analytical results were matched to similar data concerning local natural clay sources and to coeval tableware productions from other sites in the same area. The ceramic pastes used by the ancient craftsmen of Solunto in the case of this class…

PetrographyArcheologySicily Solunto Archaic-Hellenistic Tableware archaeometryEarth and Planetary Sciences (miscellaneous)Period (geology)PotteryArchaeologySettore GEO/09 -Georis. Miner.e Appl.Mineral.-Petrogr. per l'Ambi.ed i B.Cult.GeologyNatural (archaeology)Geoarchaeology
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AN HYPERBOLIC-PARABOLIC PREDATOR-PREY MODEL INVOLVING A VOLE POPULATION STRUCTURED IN AGE

2020

Abstract We prove existence and stability of entropy solutions for a predator-prey system consisting of an hyperbolic equation for predators and a parabolic-hyperbolic equation for preys. The preys' equation, which represents the evolution of a population of voles as in [2] , depends on time, t, age, a, and on a 2-dimensional space variable x, and it is supplemented by a nonlocal boundary condition at a = 0 . The drift term in the predators' equation depends nonlocally on the density of preys and the two equations are also coupled via classical source terms of Lotka-Volterra type, as in [4] . We establish existence of solutions by applying the vanishing viscosity method, and we prove stabil…

Population dynamicsPopulationType (model theory)Space (mathematics)01 natural sciencesStability (probability)Predator-prey systemsNonlinear Sciences::Adaptation and Self-Organizing SystemsApplied mathematicsQuantitative Biology::Populations and Evolution[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP]0101 mathematicseducationEntropy (arrow of time)Variable (mathematics)Mathematicseducation.field_of_studyApplied Mathematics010102 general mathematicsNonlocal boundary value problemNonlocal conservation lawsParabolic-hyperbolic equationsTerm (time)010101 applied mathematicsPopulation dynamics Predator-prey systems Parabolic-hyperbolic equations Nonlocal conservation laws Nonlocal boundary value problemHyperbolic partial differential equationAnalysis
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Multi-sensor spectral synergies for crop stress detection and monitoring in the optical domain: A review

2022

Remote detection and monitoring of the vegetation responses to stress became relevant for sustainable agriculture. Ongoing developments in optical remote sensing technologies have provided tools to increase our understanding of stress-related physiological processes. Therefore, this study aimed to provide an overview of the main spectral technologies and retrieval approaches for detecting crop stress in agriculture. Firstly, we present integrated views on: i) biotic and abiotic stress factors, the phases of stress, and respective plant responses, and ii) the affected traits, appropriate spectral domains and corresponding methods for measuring traits remotely. Secondly, representative result…

Precision agriculturemultispectralbiotic and abiotic stresatelliteSoil Sciencesolar induced fluorescenceGeologymulti-modalPrecision agriculture multi-modal solar-induced fluorescence satellite hyperspectral multispectral biotic and abiotic stressUNESCO::CIENCIAS TECNOLÓGICASITC-HYBRIDhyperspectralITC-ISI-JOURNAL-ARTICLEddc:550Computers in Earth Sciences
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Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

2021

The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy—termed the "R-clamp”—that favors the formation …

RNA virusesviruksetvirusesSimian Acquired Immunodeficiency SyndromeHIV InfectionsPathology and Laboratory MedicineSH3 domainWhite Blood CellsImmunodeficiency VirusesAnimal CellsMedicine and Health SciencesBiology (General)MammalsGenetics11832 Microbiology and virology0303 health sciencesKinase030302 biochemistry & molecular biologyEukaryotavirus diseasesTransfection3. Good healthSIVMedical MicrobiologyViral PathogensViral evolutionVirusesVertebratesProto-Oncogene Proteins c-hckApesSimian Immunodeficiency VirusPathogensCellular TypesTyrosine kinaseResearch ArticlePrimateskinaasitEvolutionary ImmunologyLineage (genetic)QH301-705.5Immune CellsImmunologyevoluutioBiologyTransfectionResearch and Analysis MethodsHIV-tartuntaMicrobiologyViral EvolutionEvolution Molecularsrc Homology Domains03 medical and health sciencesVirologyRetrovirusesGeneticsAnimalsHumansLuciferaseAmino Acid Sequencenef Gene Products Human Immunodeficiency VirusChimpanzeesMolecular Biology TechniquesMicrobial PathogensMolecular Biology030304 developmental biologyEvolutionary BiologyBlood CellsSequence Homology Amino AcidMacrophagesLentivirusOrganismsBiology and Life SciencesHIVCell BiologyRC581-607Organismal Evolution3121 General medicine internal medicine and other clinical medicineMicrobial EvolutionAmniotesHIV-1ParasitologySalt bridgeproteiinitImmunologic diseases. AllergyZoology
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A Quantitative Model for Alkane Nucleophilicity Based on C−H Bond Structural/Topological Descriptors

2020

A first quantitative model for calculating the nucleophilicity of alkanes is described. A statistical treatment was applied to the analysis of the reactivity of 29 different alkane C−H bonds towards in situ generated metal carbene electrophiles. The correlation of the recently reported experimental reactivity with two different sets of descriptors comprising a total of 86 parameters was studied, resulting in the quantitative descriptor‐based alkane nucleophilicity (QDEAN) model. This model consists of an equation with only six structural/topological descriptors, and reproduces the relative reactivity of the alkane C−H bonds. This reactivity can be calculated from parameters emerging from th…

Reactivity modelNucleophilicity010402 general chemistryTopology01 natural sciencesCatalysisC-H functionalizationMetalchemistry.chemical_compoundNucleophile23 QuímicaReactivity (chemistry)Alkanechemistry.chemical_classificationC h bond010405 organic chemistryChemistryGeneral MedicineGeneral ChemistryQuantitative model0104 chemical sciencesvisual_artElectrophileAlkanes descriptorsvisual_art.visual_art_mediumCarbeneAngewandte Chemie International Edition
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Soil erosion modelling: A bibliometric analysis.

2021

16 Pags.- 12 Figs.- 8 Tabls.

Research impactCalibration (statistics)Geography & travelDecision treeParticipatory networkAgricultural engineering[SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study010501 environmental sciencesParticipatory modeling01 natural sciencesBiochemistryBibliometricITC-HYBRID03 medical and health sciencesSoil0302 clinical medicineCitation analysisBenchmark (surveying)Citation analysis; Participatory network; Research impact; Soil erosion modelling; Systematic literature review; Agriculture; Publications; Soil; Bibliometrics; Soil Erosionddc:550030212 general & internal medicine0105 earth and related environmental sciencesGeneral Environmental Scienceddc:910Soil ErosionWIMEKSystematic literature reviewPublicationsAgricultureBodemfysica en Landbeheer15. Life on landPE&RCBibliographic couplingSoil Physics and Land ManagementCitation analysis13. Climate actionCitation analysiSoil erosion modellingBibliometricsITC-ISI-JOURNAL-ARTICLEErosionEnvironmental sciencePublicationScale (map)ISRIC - World Soil InformationEnvironmental research
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