Search results for "C11"
showing 10 items of 59 documents
The Horror, the Horror!
2010
The Latest Return of Sartre
2000
The Ancient Pedigree of Post-Factualism
2016
Characterization of the NAD-Dependent Human Histone Deacetylases Gene Sirtuin 1 and Its Implications on Aging and the Development of Malignant Diseas…
2006
Abstract A dysregulation of the tightly controlled equilibrium of acetylation and deacetylation plays a causative role in the generation as well as in the suppression of cancer. Histone acetylation modifiers are therefore gaining increasing attention as potential targets in the treatment of cancer. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs). The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We…
Guerre juste et droit de la guerre dans l’"Encyclopédie"
2010
In the vast reform program sketched by the chevalier de Jaucourt in the Encyclopédie for the modernization of justice, one point is particularly close to his heart: humanizing the rules of war. Drawing from the philosophies of Grotius and Montesquieu, his articles devoted to the question of a just war (CONQUEST, DAMAGE, DESERTER, ENEMY, PRISONNER OF WAR, RETALIATION, WAR, etc.) argue for the subordination of the political to moral reason and work towards the advent of international humanitarian law.
Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors
2010
The human genome is epigenetically organized through a series of modifications to the histone proteins that interact with the DNA. In cancer, many of the proteins that regulate these modifications can be altered in both function and expression. One example of this is the family of histone deacetylases (HDACs), which as their name implies remove acetyl groups from the histone proteins, allowing for more condensed nucleosomal structure. HDACs have increased expression in cancer and are also believed to promote carcinogenesis through the acetylation and interaction with key transcriptional regulators. Given this, small molecule histone deacetylases inhibitors have been identified and developed…
Distinct Site Specificity of Two Pea Histone Deacetylase Complexes
2001
We report on the site specificity of two intact pea histone deacetylase complexes. HD1 deacetylates lysines 5 and 16 of H4 in the order K16 > K5, while in the case of H3 the preferred order is K4 >> K18 approximately K9. The specificity of the HD2 complex is markedly different. The preferred residues in H4 are K8 approximately K5 > K16, while in H3 deacetylation, the complex HD2 prefers sites 4 and 18. To obtain these results, we have used a novel procedure based on the SPOT technique, a method to synthesize peptides on membrane supports. Different sets of membranes with sequentially overlapping histone peptides containing acetylated lysines in the sites corresponding to all in vivo acetyla…
Characterization of pea histone deacetylases
1988
The present paper is the first report on histone deacetylases from plants. Three enzyme fractions with histone deacetylase activity (HD0, HD1 and HD2) have been partially purified from pea (Pisum sativum) embryonic axes. They deacetylate biologically acetylated chicken histones and, to a lesser extent, chemically acetylated histones, this being a criterion of their true histone deacetylase nature. The three enzymes are able to accept nucleosomes as substrates. HD1 is not inhibited by n-butyrate up to 50 mM, whereas HD0 and HD2 are only slightly inhibited, thereby establishing a clear difference to animal histone deacetylases. The three activities are inhibited by acetate, Cu(2+) and Zn(2+) …
“Another Munich We Just Cannot Afford”: Historical Metonymy In Politics
2016
The appeasement of Hitler and the Munich Agreement is a rhetorical comparison used commonly in international relations to defend politico-military action. On the basis of conceptual history and rhetorics, we examine cases of political speech in this paradigm. Firstly, we discuss time and conceptualize experience into first and second order experiences. Secondly, the roles of metaphor, metonymy and analogy in relation to thought and action are examined. We then contextualise Munich 1938, and present three cases demonstrating the political usage of this metonymy since WWII. These range from the Suez Crises to the Gulf War and on-going War on Terror. These cases show that “Munich” can be used …