Search results for "C25"
showing 10 items of 566 documents
Tumor-infiltrating lymphocytes and breast cancer: Beyond the prognostic and predictive utility
2017
The importance of the immune system as a potent anti-tumor defense has been consolidated in recent times, and novel immune-related therapies are today demonstrating a strong clinical benefit in the setting of several solid neoplasms. Tumor-infiltrating lymphocytes reflect the attempt of the host to eradicate malignancies, and during the last decades, they have been shown to possess an interesting prognostic utility for breast cancer, especially in case of HER2 positive and triple-negative molecular subtypes. In parallel, the clinical evaluation of tumor-infiltrating lymphocytes has been shown to effectively predict treatment outcomes in both neoadjuvant and adjuvant settings. Currently, tu…
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis
2008
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…
A Franks' lemma that preserves invariant manifolds
2009
A well-known lemma by John Franks asserts that one obtains any perturbation of the derivative of a diffeomorphism along a periodic orbit by a $C^1$-perturbation of the whole diffeomorphism on a small neighbourhood of the orbit. However, one does not control where the invariant manifolds of the orbit are, after perturbation. We show that if the perturbated derivative is obtained by an isotopy along which some strong stable/unstable manifolds of some dimensions exist, then the Franks perturbation can be done preserving the corresponding stable/unstable semi-local manifolds. This is a general perturbative tool in $C^1$-dynamics that has many consequences. We give simple examples of such conseq…
Quasi-isometrically embedded subgroups of braid and diffeomorphism groups
2005
We show that a large class of right-angled Artin groups (in particular, those with planar complementary defining graph) can be embedded quasi-isometrically in pure braid groups and in the group of area preserving diffeomorphisms of the disk fixing the boundary (with respect to the $L^2$-norm metric); this extends results of Benaim and Gambaudo who gave quasi-isometric embeddings of $F\_n$ and $\Z^n$ for all $n>0$. As a consequence we are also able to embed a variety of Gromov hyperbolic groups quasi-isometrically in pure braid groups and in the diffeomorphism group of the disk. Examples include hyperbolic surface groups, some HNN-extensions of these along cyclic subgroups and the fundame…
On List Coloring with Separation of the Complete Graph and Set System Intersections
2022
We consider the following list coloring with separation problem: Given a graph $G$ and integers $a,b$, find the largest integer $c$ such that for any list assignment $L$ of $G$ with $|L(v)|= a$ for any vertex $v$ and $|L(u)\cap L(v)|\le c$ for any edge $uv$ of $G$, there exists an assignment $\varphi$ of sets of integers to the vertices of $G$ such that $\varphi(u)\subset L(u)$ and $|\varphi(v)|=b$ for any vertex $u$ and $\varphi(u)\cap \varphi(v)=\emptyset$ for any edge $uv$. Such a value of $c$ is called the separation number of $(G,a,b)$. Using a special partition of a set of lists for which we obtain an improved version of Poincar\'e's crible, we determine the separation number of the c…
Statistics of transitions for Markov chains with periodic forcing
2013
The influence of a time-periodic forcing on stochastic processes can essentially be emphasized in the large time behaviour of their paths. The statistics of transition in a simple Markov chain model permits to quantify this influence. In particular the first Floquet multiplier of the associated generating function can be explicitly computed and related to the equilibrium probability measure of an associated process in higher dimension. An application to the stochastic resonance is presented.
Sentinel Lymph Node in Aged Endometrial Cancer Patients “The SAGE Study”: A Multicenter Experience
2021
ObjectiveThe incidence of endometrial cancer is increasing in elderly people. Considering that aging progressively affects lymphatic draining function, we aimed to define its impact on IGC uptake during SLN mapping.MethodsA multicenter retrospective cohort of endometrial cancer patients with apparently early-stage endometrial cancer undergoing complete surgical staging with SLN dissection was identified in four referral cancer centers from May 2015 to March 2021. Patients were classified in Group 1 (<65 years old) and Group 2 (≥65 years old). The primary endpoint was the assessment of the overall, bilateral, and unsuccessful SLN mapping in the two groups. Secondary outcomes were the …
On the tensor degree of finite groups
2013
We study the number of elements $x$ and $y$ of a finite group $G$ such that $x \otimes y= 1_{_{G \otimes G}}$ in the nonabelian tensor square $G \otimes G$ of $G$. This number, divided by $|G|^2$, is called the tensor degree of $G$ and has connection with the exterior degree, introduced few years ago in [P. Niroomand and R. Rezaei, On the exterior degree of finite groups, Comm. Algebra 39 (2011), 335--343]. The analysis of upper and lower bounds of the tensor degree allows us to find interesting structural restrictions for the whole group.
Correlation between cell line chemosensitivity and protein expression pattern as new approach for the design of targeted anticancer small molecules
2022
BACKGROUND AND RATIONALE: Over the past few decades, several databases with a significant amount of biological data related to cancer cells and anticancer agents (e.g.: National Cancer Institute database, NCI; Cancer Cell Line Encyclopedia, CCLE; Genomic and Drug Sensitivity in Cancer portal, GDSC) have been developed. The huge amount of heterogeneous biological data extractable from these databanks (among all, drug response and protein expression) provides a real foundation for predictive cancer chemogenomics, which aims to investigate the relationships between genomic traits and the response of cancer cells to drug treatment with the aim to identify novel therapeutic molecules and targets…
Glutathione in Cancer Cell Death
2011
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death. The intracellular thiol redox state (controlled by GSH) is one of the endogenous effectors involved in regulating the mitochondrial permeability transition pore complex and, in consequence, thiol oxidation can be a causal factor in the mitochondrion-based mechanism that leads to cell death. Nevertheless GSH depletion is a common feature not only of apoptosis but also of other types of cell death. Indeed rates of GSH synthesis and…