Search results for "C2"
showing 10 items of 879 documents
RNA-binding CSD-C2 protein and its interactors in nerve cell differentiation
2010
Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling
2019
Oncogenic HPV types are major human carcinogens. Under hypoxia, HPV-positive cancer cells can repress the viral E6/E7 oncogenes and induce a reversible growth arrest. This response could contribute to therapy resistance, immune evasion, and tumor recurrence upon reoxygenation. Here, we uncover evidence that HPV oncogene repression is mediated by hypoxia-induced activation of canonical PI3K/mTORC2/AKT signaling. AKT-dependent downregulation of E6/E7 is only observed under hypoxia and occurs, at least in part, at the transcriptional level. Quantitative proteome analyses identify additional factors as candidates to be involved in AKT-dependent E6/E7 repression and/or hypoxic PI3K/mTORC2/AKT ac…
The second component of human complement: Detection of two hemolytic forms in plasma by pH Variation
1988
The second component of human complement (C2) in pseudoglobulin prepared from normal plasma eluted as a single peak at high conductivity (30 mS) and pH 4.5 from the cationic exchangers S-Sepharose or Mono S in the Fast Protein Liquid Chromatography (FPLC) System. The C2 was stable at pH 4.5 and 0 degrees C if enzyme inhibitors were used and the pH was raised to 6.0 after elution from the columns. After rechromatography on Mono S in the FPLC System at the median isoelectric point of 5.5 or pH 6.0, the C2 eluted as two distinct hemolytic forms: the first peaked at 16 mS, the second at 30 mS. The two forms of C2 did not correlate with the allotypic variant of C2 in individual, normal human pla…
Functional Assessment of Variants in the TSC1 and TSC2 Genes Identified in Individuals with Tuberous Sclerosis Complex
2011
The effects of missense changes and small in-frame deletions and insertions on protein function are not easy to predict, and the identification of such variants in individuals at risk of a genetic disease can complicate genetic counselling. One option is to perform functional tests to assess whether the variants affect protein function. We have used this strategy to characterize variants identified in the TSC1 and TSC2 genes in individuals with, or suspected of having, Tuberous Sclerosis Complex (TSC). Here we present an overview of our functional studies on 45 TSC1 and 107 TSC2 variants. Using a standardized protocol we classified 16 TSC1 variants and 70 TSC2 variants as pathogenic. In add…
Clubs de convergence et effets de débordements géographiques : une analyse spatiale sur données régionales européennes, 1980-1995
2007
Our article offers an econometric model of spatial interactions for the empirical analysis of growth in European regions over the period 1980-1995. The model detects spatial spillover effects and makes it possible to take account of the European economy’s strong polarization. More specifically, by factoring in both spatial autocorrelation and spatial heterogeneity, we characterize the economic polarization pattern in European regions, identify convergence clubs, and model them as spatial regimes. We estimate a two-regime model with spatially autocorrelated errors and show that the convergence process differs between the two regimes. We find a strongly significant spatial spillover effect : …
Testing the Sobolev property with a single test plan
2020
We prove that in a vast class of metric measure spaces (namely, those whose associated Sobolev space is separable) the following property holds: a single test plan can be used to recover the minimal weak upper gradient of any Sobolev function. This means that, in order to identify which are the exceptional curves in the weak upper gradient inequality, it suffices to consider the negligible sets of a suitable Borel measure on curves, rather than the ones of the $p$-modulus. Moreover, on $\sf RCD$ spaces we can improve our result, showing that the test plan can be also chosen to be concentrated on an equi-Lipschitz family of curves.
Neuropsychological rehabilitation in children with central nervous system tumors and irradiated leukemias
2012
Actualmente la intervención e investigación en psicooncología pediátrica se dirige hacia la evaluación de las consecuencias de la enfermedad y los efectos secundarios de los tratamientos, y a los factores predictivos tanto de desajustes como de aspectos adaptativos a la enfermedad del paciente y de su familia. Las tasas de curación alcanzadas en la actualidad, nos permiten contar con un número considerable de supervivientes de cáncer infantil, susceptibles de ser evaluados y poder determinar así las secuelas a largo plazo de la enfermedad y sus procedimientos terapéuticos. Además de incrementar considerablemente la supervivencia, también se ha mejorado la calidad de vida de los niños, media…
Learning Curve in Surgical Treatment of Odontoid Fixation for a Series of Type II C2 Fractures
2019
The craniovertebral junction (CVJ) is a complex anatomical area upon which most of the motion of the upper cervical spine depends [1]. Because of its unique range of motion, the CVJ is subject to several types of traumatic injury; it has been shown that odontoid fractures are the most common ones in the general population and are the most common isolated spinal fractures [2]. Accounting for up to 18% of all cervical fractures, odontoid fractures are the most common ones in elderly patients [3], in whom they account for up to 60% of spinal cord injuries [4].
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome
2021
Simple Summary Lifestyle modifies cancer risk in the general public. How lifestyle modifies cancer risk in individuals carrying the inherited pathogenic gene variants in DNA mismatch repair genes (Lynch syndrome) remains understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, physical activity, and cancer risk among Finnish Lynch syndrome carriers (n = 465, 54% women). The results of our study indicated that longitudinal weight gain increases cancer risk, whereas being highly physically active during adulthood could decrease cancer risk in men. Further, women were observed to be less prone to lifestyle-related risk factors …
The perceptions of parents of children with cancer about changes in family relations
2012
Objetivos: conocer cómo perciben los padres los cambios producidos en las relaciones familiares debidos a un cáncer pediátrico. Método: Se ha utilizado una metodología de investigación grupal (grupos de autoayuda) y cualitativa (análisis del discurso de los participantes en las sesiones grupales). La muestra la constituyen 22 madres/padres cuyos hijos hace más de dos años que han contraído la enfermedad. Las sesiones grupales se realizaron en la sede de ASPANION (Asociación de padres de niños oncológicos de la Comunidad Valenciana) en Valencia. Resultados: Se constata cómo la enfermedad cambia las relaciones: – Con la pareja: redistribución de roles, diferentes formas de reaccionar y de asu…