Search results for "C2"
showing 10 items of 879 documents
Practical Considerations for the Daratumumab Management in Portuguese Routine Clinical Practice: Recommendations From an Expert Panel of Hematologists
2022
The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact patients’ quality of life and outcomes, the treatment decision should consider different factors and be weighted for each patient individually. Here, we aimed to guide clinicians using daratumumab treatment for MM by addressing practical real-world considerations based on an expert pa…
High Output Heart Failure in Multiple Myeloma: Pathogenetic Considerations.
2022
The high output heart failure is a clinical condition in which the systemic congestion is associated to a high output state, and it can be observed in a non-negligible percentage of hematological diseases, particularly in multiple myeloma, a condition in which the risk of adverse cardiovascular events may increase, with a worse prognosis for patients. For this reason, though an accurate literature search, we provided in this review a complete overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma. Indeed, this clinical finding is present in the 8% of multiple myeloma patients, and it may be caused by artero-venous shunts, enhanced angioge…
Global representation and multiscale expansion for the Dirichlet problem in a domain with a small hole close to the boundary
2019
For each pair (Formula presented.) of positive parameters, we define a perforated domain (Formula presented.) by making a small hole of size (Formula presented.) in an open regular subset (Formula presented.) of (Formula presented.) ((Formula presented.)). The hole is situated at distance (Formula presented.) from the outer boundary (Formula presented.) of the domain. Thus, when (Formula presented.) both the size of the hole and its distance from (Formula presented.) tend to zero, but the size shrinks faster than the distance. Next, we consider a Dirichlet problem for the Laplace equation in the perforated domain (Formula presented.) and we denote its solution by (Formula presented.) Our ai…
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax
2019
Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro‐survival and anti‐apoptotic roles through molecule phosphorylated extracellular signal‐regulated kinase1/2 (p‐ERK1/2) in cardiomyocytes. However, it is still unclear if silencing of C3G may increase cell survival inhibition and apoptosis in cardiomyocytes, and whether C3G silence induced injuries are reduced by the overexpression of C3G through regulation of p‐ERK1/2 and pro‐apoptotic molecule Bax. In this study, the rat‐derived H9C2 cardiomyocytes were infected with C3G small hairpin RNA interference recombinant lentiviruses, which silenced the endogenous C3G expression in the ca…
Assessing the Open Trenches in Screening Railway Ground-Borne Vibrations by Means of Artificial Neural Network
2009
Reducing ground borne vibrations in urban areas is a very challenging task in railway transportation. Many mitigation measures can be considered and applied; among these open trenches are very effective. This paper deals with the study of the effect, in terms of reduction of vertical and horizontal displacements and velocities, of the open trenches. 2D FEM simulations have been performed and several open trench configurations have been analysed varying the main geometric features such as width and depth, distance from the rail, thickness of the soil layer over the rigid bedrock, type of the ground, ratio between the depth of the trench, and the thickness of the soil layer. For quantifying t…
Extremal Irregular Digraphs
2018
A digraph is called irregular if its distinct vertices have distinct degree pairs. An irregular digraph is called minimal (maximal) if the removal of any arc (addition of any new arc) results in a non-irregular digraph. It is easily seen that the minimum sizes among irregular n-vertex whether digraphs or oriented graphs are the same and are asymptotic to (√2/3) n3/2; maximum sizes, however, are asymptotic to n2 and n2/2, respectively. Let s stand for the sum of initial positive integers, s = 1, 3, 6, . . . . An oriented graph Hs and a digraph Fs, both large (in terms of the size), minimal irregular, and on any such s vertices, s ≥ 21, are constructed in [Large minimal irregular digraphs, Op…
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
Precio no monetario percibido en alojamientos e-peer-to-peer. La perspectiva de los huéspedes de Airbnb
2021
[EN] Price is considered as a key variable in predicting buying behavior. However, few studies have focused on how non-monetary price is affected and can affect other components of the consumer endogenous variables. This paper seeks (1) to analyze the effects of antecedents of behavioural price (past experience, the benefits and risks of peer to peer accommodation services) on the guest perceived price, and (2) to determine the effect of this price and past experience on guest intentions. With a sample of 136 Airbnb guests and the use of SEM, results show that past experience, financial risk, and time risk influence the non-monetary perceived price. This price and past experience affect gue…
Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the safe use of three aqueous solutions of hydrogen…
2020
* This record is given in both English and Spanish. The company Peroxychem Spain S.L.U. has requested a safety assessment of the use of three aqueous solutions of hydrogen peroxide, acetic acid and peracetic acid as processing aids. 1-Hydroxy ethylidene-1,1-diphosphonic acid (HEDP) was used as a stabiliser. The proposed use is the antibacterial treatment of water used to wash citrus fruits and peppers in processing plants. When this water is disinfected, it can be reused for the consecutive washing of fruits and vegetables through a recirculating system, maintaining it in appropriate conditions and thus reducing water usage. These are the same aqueous solutions previously assessed by the AE…