Search results for "C3"
showing 10 items of 1295 documents
Widespread Decoding of Tactile Input Patterns Among Thalamic Neurons
2021
Whereas, there is data to support that cuneothalamic projections predominantly reach a topographically confined volume of the rat thalamus, the ventroposterior lateral (VPL) nucleus, recent findings show that cortical neurons that process tactile inputs are widely distributed across the neocortex. Since cortical neurons project back to the thalamus, the latter observation would suggest that thalamic neurons could contain information about tactile inputs, in principle regardless of where in the thalamus they are located. Here we use a previously introduced electrotactile interface for producing sets of highly reproducible tactile afferent spatiotemporal activation patterns from the tip of di…
Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology
2020
Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of both upper and lower motor neurons. Despite decades of research, we still to date lack a cure or disease modifying treatment, emphasizing the need for a much-improved insight into disease mechanisms and cell type vulnerability. Altered neuronal excitability is a common phenomenon reported in ALS patients, as well as in animal models of the disease, but the cellular and circuit processes involved, as well as the causal relevance of those observations to molecular alterations and final cell death, remain poorly understood. Here, we review evidence from clinical studies, cell type-specific electrophysi…
''Dual'' gravity: Using spatial econometrics to control for multilateral resistance.
2007
We propose a quantity-based `dual' version of the gravity equation that yields an estimating equation with both cross-sectional interdependence and spatially lagged error terms. Such an equation can be concisely estimated using spatial econometric techniques. We illustrate this methodology by applying it to the Canada-U.S. data set used previously, among others, by Anderson and van Wincoop (2003) and Feenstra (2002, 2004). Our key result is to show that controlling directly for spatial interdependence across trade flows, as suggested by theory, significantly reduces border effects because it captures `multilateral resistance'. Using a spatial autoregressive moving average specification, we …
Growth and convergence in Africa: The impact of spatial effects
2010
The aim of this paper is to study the impact of spatial effects on convergence process in Africa over the period 1975-2000. Taking into account these effects through the methodology of Exploratory Spatial Data Analysis (ESDA) and spatial econometrics, we focus on the geographical dimension of economic convergence of African countries. This allows us to deal with spatial autocorrelation which is a consequence of econometric interdependences due to geographic spillovers. Indeed, countries economic performance hides specific geographical patterns providing information on the importance of location on economic dynamics. Our results prove the existence of convergence process in Africa through a …
IMPORTANCIA DE LAS PERTURBACIONES EXTERNAS EN LA ECONOMÍA ESPAÑOLA TRAS LA INTEGRACIÓN: ¿TAMAÑO DEL SHOCK O GRADO DE RESPUESTA?
2005
This paper analyses whether the impact of European shocks in the Spanisheconomy has increased after the entry of Spain in the European Community. UsingVAR models, we try to disentangle whether the change in the importance of Europe isdue to a change in the size of the shocks or in the propagation effects. The results showsthat after 1986, despite the decrease in the size of European shocks, their impact on theSpanish business cycle has increases due to a larger sensitivity of the Spanish economyto these shocks. El objetivo de este trabajo es analizar si ha aumentado la influencia de los shocks europeos en la economía española tras el proceso de integración en Europa, distinguiendo si los ca…
Potential Growth and Business Cycle in the Spanish Economy: Implications for Fiscal Policy
2007
An accurately estimation of the cyclical position of an economy is a necessary condition for the success of fiscal stabilisation policies. In this paper we show that the estimation of the output gap by means of decomposing a production function produces similar results to univariate and multivariate methods, increasing their robustness and allowing us to conclude that most of the information on the economic cycle is included in the cyclical component of the unemployment rate. The results also indicate that there is reduced uncertainty about the periods when the Spanish economy has clearly been in a deep recession or in a sharp expansion. These periods have been limited and of relatively sho…
THE IMPACT OF FISCAL POLICY ON ECONOMIC GROWTH IN THE COUNTRIES OF EASTERN EUROPE
2015
This paper deals with the effects of fiscal policy on economic growth in 10 countries of Eastern Europe. For this analysis we to use two regression models. The results of the first model provide information on the factors that influence economic growth. Thus, direct taxes, indirect taxes, total income taxes, social contributions and the economic crisis had an effect on economic growth. Of these variables, total taxable income had a positive effect and indirect taxes and social contributions had a direct negative effect on economic growth. In the second model, the analysis confirmed that a significant effect on economic growth have had other direct taxes, social contributions of the employer…
Models Used for Measuring Customer Engagement
2013
The purpose of the paper is to define and measure the customer engagement as a forming element of the relationship marketing theory. In the first part of the paper, the authors review the marketing literature regarding the concept of customer engagement and summarize the main models for measuring it. One probability model (Pareto/NBD model) and one parametric model (RFM model) specific for the customer acquisition phase are theoretically detailed. The second part of the paper is an application of the RFM model; the authors demonstrate that there is no statistical significant variation within the clusters formed on two different data sets (training and test set) if the cluster centroids of t…
Social capital formation across space: proximity and trust in European regions
2013
An extensive economics and regional science literature has discussed the importance of social capital for economic growth and development. Yet, what social capital is and how it is formed are elusive issues, which require further investigation. Here, we refer to social capital in terms of “civic” capital and “good culture,” as rephrased by Guiso, Sapienza, and Zingales and Tabellini. The accumulation of this kind of capital allows the emerging of regional informal institutions, which may help explaining differences in regional development. In this article, we take a regional perspective and use exploratory space and space–time methods to assess whether geography, via proximity, contributes…
Behavioral Profiling in Early Adolescence and Early Adulthood of Male Wistar Rats After Short and Prolonged Maternal Separation
2020
Early-life stress and its possible correlations to genes, environment, and later health outcomes can only be studied retrospectively in humans. Animal models enable the exploration of such connections with prospective, well-controlled study designs. However, with the recent awareness of replicability issues in preclinical research, the reproducibility of results from animal models has been highlighted. The present study aims to reproduce the behavioral effects of maternal separation (MS) previously observed in the multivariate concentric square fieldTM (MCSF) test. A second objective was to replicate the adolescent behavioral profiles previously described in the MCSF test. Male rats, subjec…