Search results for "C3"
showing 10 items of 1295 documents
Full spectra coloration and condition-dependent signaling in a skin-based carotenoid sexual ornament
2020
AbstractCarotenoid-based traits commonly act as condition-dependent signals of quality to both males and females. Such colors are typically quantified using summary metrics (e.g., redness) derived by partitioning measured reflectance spectra into blocks. However, perceived coloration is a product of the whole spectrum. Recently, new methods have quantified a range of environmental factors and their impact on reflection data at narrow wavebands across the whole spectrum. Using this approach, we modeled the reflectance of red integumentary eye combs displayed by male black grouse (Lyrurus tetrix) as a function of ornament size and variables related to male quality. We investigated the strengt…
Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana
2015
Highlight Cyclic expression of copper transport and the responses to copper deficiency are integrated into the light and circadian–oscillator signalling in plants.
Selective photocatalytic oxidation of aromatic alcohols in water by using P-doped g-C3N4
2018
A set of bare and P-doped graphitic carbon nitride (g-C3N4) photocatalysts has been prepared by thermal condensation of melamine, urea or thiourea. For the sake of comparison, a g-C3N4 sample obtained in the presence of cyanuric acid and thermally exfoliated C3N4 powders were also studied. The materials were physicochemically characterized and their photocatalytic activity was studied for the selective oxidation of benzyl alcohol (BA), 4-methoxy benzyl alcohol (4-MBA) and piperonyl alcohol (PA) in water suspension both under UV and visible light irradiation. The influence of the type and position of the substituents on conversion and selectivity to aldehyde was remarkable. The presence of P…
Análisis de los factores ligados al diagnóstico del trastorno por déficit de atención e hiperactividad en la infancia
2017
Resumen: Introducción: El trastorno por déficit de atención e hiperactividad (TDAH) es un trastorno neuropsiquiátrico de origen multifactorial. El objetivo de este estudio es determinar el porcentaje de pacientes que presentan TDAH del global de los enviados a la consulta por este motivo, y explorar los factores epidemiológicos y clínicos asociados al diagnóstico. Pacientes y métodos: Estudio retrospectivo analítico de una muestra de pacientes derivados a la consulta de neuropediatría por sospecha de TDAH, a la que se le aplican los criterios diagnósticos del DSM-IV. Se realiza un análisis de regresión logística para explorar los factores asociados al diagnóstico. Resultados: De los 280 pac…
Consenso para el diagnóstico, tratamiento y seguimiento del paciente con distrofia muscular de Duchenne
2019
Resumen: Introducción: La distrofia muscular de Duchenne (DMD) es la miopatía más frecuente en niños, con una prevalencia mundial de aproximadamente 0,5 por cada 10.000 varones. Se caracteriza por una debilidad muscular progresiva al inicio de la infancia con aparición posterior de complicaciones musculoesqueléticas, respiratorias y cardíacas que ocasionan discapacidad, dependencia y muerte prematura. Actualmente su tratamiento se fundamenta en medidas sintomáticas multidisciplinares que han modificado favorablemente el curso de la enfermedad, por lo que resulta crucial establecer unas directrices claras y actualizadas que permitan tanto una detección temprana de la enfermedad como un adecu…
Patología vascular: ¿causa o efecto en la enfermedad de Alzheimer?
2018
Resumen: Introducción: La enfermedad de Alzheimer (EA) es la principal enfermedad neurodegenerativa cortical. Su incidencia aumenta con la edad, lo que provoca importantes problemas médicos, sociales y económicos, especialmente en países con población envejecida. Objetivo: El objetivo de esta revisión es poner de manifiesto las evidencias que existen sobre el modo en que la disfunción vascular puede contribuir al deterioro cognitivo en la EA, así como las posibilidades terapéuticas que de ello podrían derivarse. Desarrollo: La hipótesis vascular ha surgido como alternativa a la hipótesis de la cascada amiloide como explicación de la fisiopatología de la EA. Esta hipótesis sitúa en los vasos…
La alteración de la mielina en la enfermedad de Alexander
2018
Resumen: Introducción: La enfermedad de Alexander (AxD) es una leucodistrofia. Su base patológica, junto a la pérdida de mielina, es la aparición de los cuerpos de Rosenthal, que son inclusiones citoplasmáticas en células astrocitarias. Mutaciones en el gen que codifica la GFAP se han identificado como una base genética para AxD. Sin embargo, no se conoce el mecanismo por el cual estas variantes producen la enfermedad. Desarrollo: La hipótesis más extendida es que AxD se desarrolla por un mecanismo por ganancia de función debido al incremento de GFAP. Sin embargo, este mecanismo no explica la pérdida mielínica, dado que los modelos experimentales que expresan GFAP normal o mutada no generan…
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…
LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.
2017
The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention of LRP1 in the ER leads to decreased APP cell surface levels and in turn, to reduced Aβ secretion. Here, we extended the biochemical and immunocytochemical analyses by showing via live cell imaging analyses in primary neurons that LRP1 and APP are transported only partly in common (one third) but to a higher degree in distinct fast axonal transport vesicles. Interestingly, co-expression of LRP1 a…
Molecular and clinical studies in five index cases with novel mutations in the GLA gene
2016
Fabry disease is a metabolic and lysosomal storage disorder caused by the functional defect of the α-galactosidase A enzyme; this defect is due to mutations in the GLA gene, that is composed of seven exons and is located on the long arm of the X-chromosome (Xq21–22). The enzymatic deficit is responsible for the accumulation of glycosphingolipids in lysosomes of different cellular types, mainly in those ones of vascular endothelium. It consequently causes a cellular and microvascular dysfunction. In this paper, we described five novel mutations in the GLA gene, related to absent enzymatic activity and typical manifestations of Fabry disease. We identified three mutations (c.846_847delTC, p.E…