Search results for "C3"
showing 10 items of 1295 documents
Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice
2015
Copyright © 2015 Fortes-Marco, Lanuza, Martínez-García and Agustín-Pavón.
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
2015
Rats of the Wistar Albino Glaxo/Rij (WAG/Rij) strain show symptoms resembling human absence epilepsy. Thalamocortical neurons of WAG/Rij rats are characterized by an increased HCN1 expression, a negative shift in Ih activation curve, and an altered responsiveness of Ih to cAMP. We cloned HCN1 channels from rat thalamic cDNA libraries of the WAG/Rij strain and found an N-terminal deletion of 37 amino acids. In addition, WAG-HCN1 has a stretch of six amino acids, directly following the deletion, where the wild-type sequence (GNSVCF) is changed to a polyserine motif. These alterations were found solely in thalamus mRNA but not in genomic DNA. The truncated WAG-HCN1 was detected late postnatal …
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
2015
Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …
Neural Adaptation to Optical Quality Defects
2010
From an optical perspective the eye is far from perfect. This is a fact that is extensively supported by literature; for instance, Prof. Navarro recently provided us with a fantastic critical review on the various theories behind the different eye models and their flaws.1 The human eye has considerable amounts of higher-order aberrations even when it is emmetropic,2 with great inter-individual variability. Besides, higher-order aberrations are still postulated to have a role in the development of the refractive error, although it is not clear the extent to which this may be (see Charman WN for a review).3 The known optical limitations of the normal human eye raised the question as to what t…
Weak and strong convergence of an inertial proximal method for solving bilevel monotone equilibrium problems
2022
In this paper, we introduce an inertial proximal method for solving a bilevel problem involving two monotone equilibrium bifunctions in Hilbert spaces. Under suitable conditions and without any restrictive assumption on the trajectories, the weak and strong convergence of the sequence generated by the iterative method are established. Two particular cases illustrating the proposed method are thereafter discussed with respect to hierarchical minimization problems and equilibrium problems under saddle point constraint. Furthermore, a numerical example is given to demonstrate the implementability of our algorithm. The algorithm and its convergence results improve and develop previous results i…
Tracking Changes in Frontal Lobe Hemodynamic Response in Individual Adults With Developmental Language Disorder Following HD tDCS Enhanced Phonologic…
2020
Background: Current research suggests a neurobiological marker of developmental language disorder (DLD) in adolescents and young adults may be an atypical neural profile coupled with behavioral performance that overlaps with that of normal controls. Although many imaging techniques are not suitable for the study of speech and language processing in DLD populations, fNIRS may be a viable option. In this study we asked if fNIRS can be used to identify atypical cortical activation patterns in individual adults with DLD and track potential changes in cortical activation patterns following a phonological working memory training protocol enhanced with anodal HD tDCS stimulation to the presuppleme…
"Table 28" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
SC$(3,2)$ with 3-subevent method in Xe-Xe collisions at $\sqrt{s_{NN}} = 5.44$ TeV.
"Table 30" of "Investigations of anisotropic flow using multi-particle azimuthal correlations in pp, p-Pb, Xe-Xe, and Pb-Pb collisions at the LHC"
2019
SC$(3,2)$ with 3-subevent method divided with $\langle v_3\{2\}^2\rangle\langle v_2\{2\}^2\rangle$ with $|\Delta \eta| > 1.0$ and 1.4 in Xe-Xe collisions at $\sqrt{s_{NN}} = 5.44$ TeV.
Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.
2006
Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…
Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor …
2020
Although theta-burst stimulation (TBS) is known to differentially modify motor cortical excitability according to stimulus conditions in humans, whether similar effects can be seen in animals, in particular rats, remains to be defined. Given the importance of experimental rat models for humans, this study explored this stimulation paradigm in rats. Specifically, this study aimed to explore corticospinal excitability after TBS in anesthetized animals to confirm its comparability with human results. Both inhibition-facilitation configurations using paired electrical stimulation protocols and the effects of the TBS paradigm on motor-evoked potentials (MEPs) in rat descending motor pathways wer…