Search results for "C4"
showing 10 items of 385 documents
Discovery of a jet-like structure with overionized plasma in the SNR IC443
2018
IC443 is a supernova remnant located in a quite complex environment since it interacts with nearby clouds. Indications for the presence of overionized plasma have been found though the possible physical causes of overionization are still debated. Moreover, because of its peculiar position and proper motion, it is not clear if the pulsar wind nebula (PWN) within the remnant is the relic of the IC443 progenitor star or just a rambling one seen in projection on the remnant. Here we address the study of IC443 plasma in order to clarify the relationship PWN-remnant, the presence of overionization and the origin of the latter. We analyzed two \emph{XMM-Newton} observations producing background-su…
Reconstruction of the Longitudinal Phase Portrait for the SC CW Heavy Ion HELIAC at GSI
2019
Proceedings of the 10th International Particle Accelerator Conference The 10th International Particle Accelerator Conference, Melbourne, Australia, 19 May 2019 - 24 May 2019; JACoW Publishing, Geneva, Switzerland 898-901 (2019). doi:10.18429/JACOW-IPAC2019-MOPTS024
Macroscopic conductivity of free fermions in disordered media
2014
We conclude our analysis of the linear response of charge transport in lattice systems of free fermions subjected to a random potential by deriving general mathematical properties of its conductivity at the macroscopic scale. The present paper belongs to a succession of studies on Ohm and Joule's laws from a thermodynamic viewpoint. We show, in particular, the existence and finiteness of the conductivity measure $\mu _{\mathbf{\Sigma }}$ for macroscopic scales. Then we prove that, similar to the conductivity measure associated to Drude's model, $\mu _{\mathbf{\Sigma }}$ converges in the weak$^{\ast } $-topology to the trivial measure in the case of perfect insulators (strong disorder, compl…
Non-cooperative Equilibria of Fermi Systems With Long Range Interactions
2019
We define a Banach space $\mathcal{M}_{1}$ of models for fermions or quantum spins in the lattice with long range interactions and explicit the structure of (generalized) equilibrium states for any $\mathfrak{m}\in \mathcal{M}_{1}$. In particular, we give a first answer to an old open problem in mathematical physics - first addressed by Ginibre in 1968 within a different context - about the validity of the so-called Bogoliubov approximation on the level of states. Depending on the model $\mathfrak{m}\in \mathcal{M}_{1}$, our method provides a systematic way to study all its correlation functions and can thus be used to analyze the physics of long range interactions. Furthermore, we show tha…
Possible protective role for C-reactive protein in atherogenesis: complement activation by modified lipoproteins halts before detrimental terminal se…
2004
Background—Previous work indicated that enzymatically remodeled LDL (E-LDL) might activate complement in atherosclerotic lesions via a C-reactive protein (CRP)–dependent and CRP-independent pathway. We sought to substantiate this contention and determine whether both pathways drive the sequence to completion.Methods and Results—E-LDL was prepared by sequential treatment of LDL with a protease and cholesteryl esterase. Trypsin, proteinase K, cathepsin H, or plasmin was used with similar results. Functional tests were used to assess total complement hemolytic activity, and immunoassays were used to demonstrate C3 cleavage and to quantify C3a, C4a, C5a, and C5b-9. E-LDL preparations activated …
Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite
2022
We thank Anna Blom for donating the C4bpα CCP1-2 expression plasmid (pET26-CCP1-2). The following reagent was obtained through BEI Resources, NIAID, NIH: Plasmid pDS56-32/RBSII-CS27IVC-6XHis, MRA-272, contributed by Photini Sinnis. The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces. Here, we report hijacking of the complement C4b-binding protein (C4bp), the regulator of the classical and lectin pathways of complement activation, by the sporozoite (SPZ) stage of the Plasmodium falciparum parasite. This was shown by direct binding …
A computational approximation for the solution of retarded functional differential equations and their applications to science and engineering
2021
<p style='text-indent:20px;'>Delay differential equations are of great importance in science, engineering, medicine and biological models. These type of models include time delay phenomena which is helpful for characterising the real-world applications in machine learning, mechanics, economics, electrodynamics and so on. Besides, special classes of functional differential equations have been investigated in many researches. In this study, a numerical investigation of retarded type of these models together with initial conditions are introduced. The technique is based on a polynomial approach along with collocation points which maintains an approximated solutions to the problem. Beside…
Rapid Detection of the ERV-K(C4) Retroviral Insertion Reveals Further Structural Polymorphism of the Complement C4 Genes in Old World Primates
2001
The fourth component of complement (C4) is coded for by two tandem-duplicated genes located in the class III region of the MHC of humans as well as a number of primates. A C4 gene size polymorphism giving rise to two gene variants of 16 and 22.3 kb length can be attributed to a complete endogenous retroviral insertion of 6.3 kb termed ERV-K(C4) in intron 9 of the long C4 genes. We developed a simple PCR-based screening assay to detect the presence of this insertion, and tested a number of unrelated animals from old world primate species. The presence of the ERV insertion in the orangutan, rhesus macaque and green monkey as well as its absence in gorillas and chimpanzees could be confirmed. …
The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligen…
2011
Contains fulltext : 97437.pdf (Publisher’s version ) (Open Access) BACKGROUND: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with ADHD and 1446 unselected siblings. The aim was to describe and analyse questionnaire data and IQ measures from all probands and siblings. In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures. METHODS: Conners' Questionnaires, St…
An Early Beginning of Citizen Science: Adolescents Experiencing Urban Energy Usages and Air Pollution
2021
Here, we report on the process and development of high school science projects, which were inspired by a citizen science program focused on urban monitoring. We gathered and discussed two 1980s projects’ data, involving 2600 students, 80 teachers, 15 scientists and 20 stakeholders. We added recent survey data from speaking with the former participants. Our analysis revealed key findings: (1) the process of a student-driven science investigation engages students in the scientific practices; (2) it is important to bring together scientists, teachers and students, reflecting the importance of multi-dimensional learning; and (3) citizen science was born before the 1990s, when the term came into…