Search results for "C63"

Anticoagulation in splanchnic and cerebral vein thrombosis: Still groping in the dark.

2020

The Asynchronous Leontief Model

1992

International audience; The traditional dynamic Leontief model is synchronous: every vertex acts simultaneously. A model with delays of action has been proposed, but it still remains synchronous. In this paper we propose an asynchronous version of the model that allows realistic computations. We fiurnish an algorithm and a program.

Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins

2012

The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore, allowing polypeptides to be transferred across or integrated into membranes. Protein translocation into the ER can occur co- and posttranslationally. In yeast, posttranslational translocation involves the heptameric translocase complex including its Sec62p and Sec63p subunits. The mammalian ER membrane contains orthologs of yeast Sec62p and Sec63p, but their function is poorly understood. Here, we analyzed the effects of excess and deficit Sec63 on various ER cargoes using human cell culture systems. The overexpression of Sec63 reduces the steady-state levels of viral and cellular multi-spanning membrane …

Analyzing structural change : the biproportional mean filter and the biproportional bimarkovian filter

1998

The biproportional filter was created to analyze structural change between two input-output matrices by removing the effect of differential growth of sectors without predetermining if the model is demand or supply-driven, but with the disadvantage that projecting a first matrix on a second is not the same thing than projecting the second matrix on the first. Here two alternative methods are proposed which has not this last drawback, with the additional advantage for the biproportional bimarkovian filter that effects of sector size are also removed. Methods are compared with an application for France for 1980 and 1996.

Dynamique de la structure industrielle française

1990

A Note on added information in the RAS Procedure: reexamination of some evidence

2006

International audience; An example in Miernyk (1977) presented a rather counterintuitive result, namely that introducing accurate exogenous information into an RAS matrix estimating procedure could lead to an estimate that was worse than one generated by RAS using no exogenous information at all. This became an oft-cited black mark against RAS. Miller and Blair (1985) included a different (and small) illustration of the same possibility. It was recently pointed out by one of us that the Miller/Blair numerical results are wrong. For that reason, we decided to reexamine all the empirical evidence we could find on the subject. While figures in both Miernyk and Miller/Blair appear to be wrong, …

Normalizing biproportional methods

2002

International audience; Biproportional methods are used to update matrices: the projection of a matrix Z to give it the column and row sums of another matrix is R Z S, where R and S are diagonal and secure the constraints of the problem (R and S have no signification at all because they are not identified). However, normalizing R or S generates important mathematical difficulties: it amounts to put constraints on Lagrange multipliers, non negativity (and so the existence of the solution) is not guaranteed at equilibrium or along the path to equilibrium.

Catastrophic risks and the pricing of catastrophe equity put options

2021

In this paper, after a review of the most common financial strategies and products that insurance companies use to hedge catastrophic risks, we study an option pricing model based on processes with jumps where the catastrophic event is captured by a compound Poisson process with negative jumps. Given the importance that catastrophe equity put options (CatEPuts) have in this context, we introduce a pricing approach that provides not only a theoretical contribution whose applicability remains confined to purely numerical examples and experiments, but which can be implemented starting from real data and applied to the evaluation of real CatEPuts. We propose a calibration framework based on his…

Granulocyte–Colony Stimulating Factor plus Plerixafor in Patients with β-thalassemia Major Results in the Effective Mobilization of Primitive CD34+ C…

2017

Successful gene therapy for β-thalassemia requires optimal numbers of autologous gene-transduced hematopoietic stem and progenitor cells (HSPCs) with high repopulating capacity. Previous studies suggested superior mobilization in these patients by the combination of granulocyte–colony stimulating factor (G-CSF) plus plerixafor over single agents. We mobilized four adult patients using G-CSF+plerixafor to assess the intra-individual variation of the circulating CD34+ cells number and subtypes preand post-plerixafor administration. The procedure was well-tolerated and the target cell dose of ≥8×10 6 CD34+ cells/kg was achieved in three of them with one apheresis procedure. The addition of ple…

Biproportional methods of structural change analysis: A typological survey

2004

International audience; Analysts often are interested in learning how much an exchange system has changed over time or how two different exchange systems differ. Identifying structural difference in exchange matrices can be performed using either 'directed' or 'undirected' methods. Directed methods are based on the computation and comparison of column- or row-normalizations of the matrices. The choice of row or column for the normalization implies a specific direction of the exchanges, so that the column-wise normalized results should not be compared to the row-wise normalized results. In this category fall the simple comparison of coefficient matrices and the causative method. Undirected m…