Search results for "CAD"
showing 10 items of 5323 documents
Territorial Intelligence and Governance.
2007
International audience; As with European experiments, in various regions in France, territorial intelligence projects have been initiated since 2003. (see the regions of Lower Normandy, Lorraine, Réunion Island, the Aquitaine region, etc.).The objective of these is to gather and exploit information which is not confined to particular sectors and the collective processing of which can contribute to durable development. Apart from institutions, civil society and the inhabitants of the territory, it is observed that companies and in particular small and medium sized enterprises are natural partners who show interest in such initiatives. Both the different economic chains and the participating …
Physiological and autonomic stress responses after prolonged sleep restriction and subsequent recovery sleep in healthy young men
2018
Purpose Sleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to prolonged sleep restriction and subsequent recovery sleep in healthy young men. Methods After two baseline (BL) nights of 8 h time in bed (TIB), TIB was restricted to 4 h per night for five nights (sleep restriction, SR, n = 15), followed by three recovery nights (REC) of 8 h TIB, representing a busy workweek and a recovery weekend. The control group (n = 8) had 8 h TIB throughout the experiment. A variety of autonomic cardiovascular parameters, together with salivary neuropeptide Y (NPY) and cortisol levels, were assessed.…
Organocatalytic Oxa-Michael/Michael/Michael/Aldol Condensation Quadruple Domino Sequence : Asymmetric Synthesis of Tricyclic Chromanes
2018
An efficient and highly stereoselective one-pot, four-component synthesis of functionalized tricyclic chromanes has been achieved through an organocatalyzed quadruple domino reaction. The reaction sequence involves an oxa-Michael/Michael/Michael/aldol condensation between alcohols, 2 equiv of acrolein, and nitrochromenes to generate the pharmaceutically important tricyclic chromanes bearing three contiguous stereogenic centers including a chiral tetrasubstituted carbon center in good domino yields (30–70%) and excellent diastereo- and enantioselectivities (>20:1 dr and >99% ee). peerReviewed
Rencontre autour du cadavre
2012
Le cadavre est «outre-signifiant, écrivait Louis-Vincent Thomas. Objet ou sujet, il a toujours suscité dans l’esprit des hommes à la fois fascination et répulsion. Pour apprivoiser la mort et se soustraire aux désordres de la putréfaction, rituels et techniques thanatologiques ont été élaborés.Construire une anthropologie du cadavre implique une connaissance des comportements sur une longue histoire et une approche pluridisciplinaire. C’est aussi aborder la mort en dissolvant le sujet dans un objet répondant à des lois bio-physico-chimiques dont il faut s’accommoder lors des rituels.C’est enfin remettre le sujet ─le défunt ─ au centre du fait social. Pour aborder ces questions, la Rencontre…
Tensor tympani muscle: strange chewing muscle
2007
This work seeks to alert medical and odontological staff to understanding and using interdisciplinary handling for detecting different pathologies’ common otic symptoms. It offers better tools for this shared symptomatology during therapy’s conservative phase. Tensor tympani muscle physiology and function in the middle ear have been veiled, even when their dysfunction and anatomical relationships may explain a group of confused otic symptoms during conventional clinical evaluation. Middle ear muscles share a common embryological and functional origin with chewing and facial muscles. This article emphasizes that these muscles share a functional neurological and anatomical dimension with the …
Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B
2020
Abstract The TRM10 family of methyltransferases is responsible for the N1-methylation of purines at position 9 of tRNAs in Archaea and Eukarya. The human genome encodes three TRM10-type enzymes, of which only the mitochondrial TRMT10C was previously characterized in detail, whereas the functional significance of the two presumably nuclear enzymes TRMT10A and TRMT10B remained unexplained. Here we show that TRMT10A is m1G9-specific and methylates a subset of nuclear-encoded tRNAs, whilst TRMT10B is the first m1A9-specific tRNA methyltransferase found in eukaryotes and is responsible for the modification of a single nuclear-encoded tRNA. Furthermore, we show that the lack of G9 methylation cau…
Supporting Institutional Awareness and Academic Advising using Clustered Study Profiles
2017
The purpose of academic advising is to help students with developing educational plans that support their academic career and personal goals, and to provide information and guidance on studies. Planning and management of the students’ study path is the main joint activity in advising. Based on a study log of passed courses, we propose to use robust, prototype-based clustering to identify a set of actual study path profiles. Such profiles identify groups of students with similar progress of studies, whose analysis and interpretation can be used for better institutional awareness and to support evidence-based academic advising. A model of automated academic advising system utilizing the possi…
Reciprocal commitment in academic careers? : Finnish implications and international trends
2016
This study explores the nature of reciprocal commitment in academic careers. The article is based on a survey conducted in autumn 2013 among fixed-term employees at eight major universities in Finland (N = 810). The analysis is focusing on researchers who have a doctoral degree and who are working on a fixed-term contract at their university (n = 308). According to our study, researchers experience their working conditions are insecure and many of them have considered leaving their universities. Despite the fact that they find their work meaningful their uncertain and poor working conditions are related to their thoughts of leaving the university. In addition in many of the cases leaving th…
Diversity begets diversity: A global perspective on gender equality in scientific society leadership.
2018
Research shows that gender inequality is still a major issue in academic science, yet academic societies may serve as underappreciated and effective avenues for promoting female leadership. That is, society membership is often self-selective, and board positions are elected (with a high turnover compared to institutions)—these characteristics, among others, may thus create an environment conducive to gender equality. We therefore investigate this potential using an information-theoretic approach to quantify gender equality (male:female ratios) in zoology society boards around the world. We compare alternative models to analyze how society characteristics might predict or correlate with the …
Equal access to the top? Measuring selection into finnish academia
2019
In this article, we draw a parallel between equality of opportunity in educational transitions and equality of opportunity in academic careers. In both cases, many methodological problems can be ameliorated by the use of longitudinal rather than cross-sectional data. We illustrate this point by using Finnish full-population register data to follow the educational and academic careers of the 1964–1966 birth cohorts from birth to the present day. We show how the Finnish professoriate is highly selected both in terms of parental background and in terms of gender. Individuals of different backgrounds differ greatly in the likelihood of completing different educational and academic transitions, …