Search results for "CAE"

Hysteroscopic removal of a gauze inadvertently retained in uterus for two years following caesarean section

2021

Despite the worldwide accomplishment of manual counting procedures of surgical textiles and instruments, cases of retained (forgotten) surgical items (RSIs) still occur. Gauzes are the most frequently RSIs, accounting for 90% of the cases because they are widely used. Approximately half of the cases occur in the context of general surgery procedures, fol- lowed by gynaecological – obstetrics surgery. The time inter- val between initial surgery, diagnosis and removal of the gauze is clinically relevant, as the morbidity and mortality are reduced if the foreign body is removed immediately after the offending operation. We report on a successful hysteroscopic identification and removal of a ga…

Contraception in diabetic women: an Italian study

2005

Abstract Over 1 year, a survey on contraception and obstetric history was performed on a cohort of 667 Caucasian fertile diabetic women (446, type 1 and 201, type 2) living in Italy. Results: Of these women, 30.4% used hormonal contraceptives, 12.0% intra-uterine device (IUD), 10.7% declared they used no contraception, 47.0% only utilised barrier and/or natural methods. However, irrespective of their previous contraceptive strategy, 7.2% of all the studied population was surgically sterilized during caesarean section. Hormonal contraception: Of these women, 60.4% was prescribed by a gynaecologist, 11.2% by a diabetologist, 15% by both of them and 13.4% by others. The proportion using oral c…

Patient‐reported outcomes in adults with type 1 diabetes in global real‐world clinical practice: the SAGE study

2021

International audience; Aims: This secondary analysis of the SAGE study aimed to evaluate the association between glycaemic control and patient-reported outcomes (PROs), in adults with type 1 diabetes (T1DM) across different age groups and regions.Materials and methods: SAGE was a multinational, cross-sectional, observational study in adults with T1DM. Data were collected at a single visit, analysed according to predefined age groups (26-44, 45-64, and ≥65 years), and reported across different regions. PRO questionnaires were applied to assess hypoglycaemia fear (Hypoglycemia Fear Survey-II [HFS-II]), diabetes-related distress (Problem Areas In Diabetes [PAID]), insulin treatment satisfacti…

Calorie Restriction in Mammals and Simple Model Organisms

2014

Calorie restriction (CR), which usually refers to a 20–40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broad…

HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans.

2010

Protein stability under changing conditions is of vital importance for the cell and under the control of a fine-tuned network of molecular chaperones. Aging and age-related neurodegenerative diseases are directly associated with enhanced protein instability. Employing C. elegans expressing GFP-tagged luciferase as a reporter for evaluation of protein stability we show that the chaperoning strategy of body wall muscle cells and neurons is significantly different and that both are differently affected by aging. Muscle cells of young worms are largely resistant to heat stress, which is directly mediated by the stress response controlled through Heat Shock Transcription Factor 1. During recover…

Phenothiazine-mediated lifespan extension in Caenorhabditis elegans

2013

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects

2021

Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify novel senolytics. We discovered the nociceptin receptor FQ opioid receptor (NOP) selective ligand 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole (MCOPPB, a compound previously studied as potential anxiolytic) as the best scoring hit. The ability of MCOPPB to eliminate senescent cells in in vitro models was further tested…

Fonti, suggestioni e intersezioni classiche, tardoantiche e medievali nell’«Alda» di Guglielmo di Blois

2019

In questo saggio vengono studiate le fonti classiche, tardoantiche e medievali dell’«Alda», commedia elegiaca latina di Guglielmo di Blois (scritta verso il 1169-1170). In particolare, dopo una presentazione generale dell’opera e una rassegna critica degli studi e delle edizioni, ci si sofferma sulle suggestioni attinte a Terenzio, Virgilio, Orazio, Ovidio, Stazio, all’«Aegritudo Perdicae», Massimiano, Boezio, Ildeberto di Lavardin, ad alcune commedie elegiache del sec. XII (il «Geta» e l’«Aulularia» di Vitale di Blois, il «Pamphilus», la «Lidia» di Arnolfo d’Orléans) e alla tradizione novellistica “orientale” («Mischle Sendebar»). This essay is founded on the classical, late and medieval s…

Inuentiones y translationes de S. Mercurio

2019

Inuentiones and translationes of the relics are part of the hagiographic dossier of a saint and provide interesting information about his cult over the centuries. For S. Mercurius of Caesarea the original texts in Greek have been lost, but we have two collections miracles in Coptic that narrate the inuentio and translatio of his relics and there is also a medieval tradition about his translatio to Benevento (Italy). From all these texts is deduced a healing cult of S. Mercurius based on the usual topics.

Amphibians of the Kayan Mentarang National Park (East Kalimantan, Indonesia): estimating overall and local species richness

2004

On the basis of surveys since 1997 and an intensive survey at the World Wildlife Fund field station at Lalut Birai in 2001, we assessed the importance of the Kayan Mentarang National Park in East Kalimantan for the conservation of Borneo's amphibian fauna. Sixty-five frog species and one Caecilian species are currently known to occur in this region. We report their occurrence in 16 subareas. Most of the species were recorded at Upper Bahau (41) and at the Lalut Birai field station (33). Based on the results of opportunistic searches and transect censuses at Lalut Birai, we argue that the amphibian diversity of the national park is still greatly underestimated.