Search results for "CAG"
showing 10 items of 492 documents
Highly specific auto-antibodies against claudin-18 isoform 2 induced by a chimeric HBcAg virus-like particle vaccine kill tumor cells and inhibit the…
2011
Abstract Strategies for antibody-mediated cancer immunotherapy, such as active immunization with virus-like particle (VLP)-based vaccines, are gaining increasing attention. We developed chimeric hepatitis B virus core antigen (HBcAg)-VLPs that display a surface epitope of the highly selective tumor-associated cell lineage marker claudin-18 isoform 2 (CLDN18.2) flanked by a mobility-increasing linker. Auto-antibodies elicited by immunization with these chimeric HBcAg-VLPs in 2 relevant species (mouse and rabbit) bind with high precision to native CLDN18.2 at physiologic densities on the surface of living cells but not to the corresponding epitope of the CLDN18.1 splice variant that differs b…
Productivity and canopy modification of Medicago arborea as affected by defoliation management and genotype in a Mediterranean environment
2004
Medicago arborea is one of the most potentially valuable fodder shrubs in a Mediterranean environment because of its high preference by small ruminants and its nutritive value. Edible biomass production is affected by agronomic and environmental factors. A study, carried out in an inland area of Sicily in the growing seasons of 1994/95, 1995/96 and 1996/97, evaluated the forage production and canopy modification in a M. arborea plantation after (i) commencing defoliation 1 or 2 years after transplanting and (ii) defoliating only in autumn (A), only in early summer (S) or in both seasons (A and S). Six clones derived from five different Mediterranean populations were used. Plant age at the f…
Generation of soliton molecules, power regulation, regeneration and sculpting of pulse profiles within a multifunction fiber laser
2018
The work of this thesis strives to provide a solution to the persistent problem of poverty of mode-locked fiber lasers, in terms of functionality and flexibility. The thesis proposes a fiber-laser cavity having the specificity of being multifunctional. The cavity is equipped with tunable components, which provide the flexibility to realize functions ranging from the generation of pulses with complex profiles (solitons, bi-solitons, tri-solitons, etc.) up to the carving of pulse profiles, passing through the regulation of peak powers, and the regeneration of severely degraded intensity profiles. The laser cavity that we propose has the specificity of being controlled by a key component, whic…
Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment following Recurrent Hypoglycemia
2013
http://www.ncbi.nlm.nih.gov/pubmed/23894333; International audience; AIMS: Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia. During hypoglycemia, ventromedial hypothalamus (VMH) production of nitric oxide (NO) and activation of its receptor soluble guanylyl cyclase (sGC) are critical for the CRR. Hypoglycemia also increases brain reactive oxygen species (ROS) production. NO production in the presence of ROS causes protein S-nitrosylation. S-nitrosylation of sGC impairs its function and induces desensitization to NO. We hypothesized that during hypoglycemia, the interaction b…
A hollow tetrahedral cage of hexadecagold dianion provides a robust backbone for a tuneable sub-nanometer oxidation and reduction agent via endohedra…
2007
We show, via density functional theory calculations, that dianionic Au16(2-) cluster has a stable, hollow, Td symmetric cage structure, stabilized by 18 delocalized valence electrons. The cage maintains its robust geometry, with a minor Jahn-Teller deformation, over several charge states (q = -1,0,+1), forming spin doublet, triplet and quadruplet states according to the Hund's rules. Endohedral doping of the Au16 cage by Al or Si yields a geometrically robust, tuneable oxidation and reduction agent. Si@Au16 is a magic species with 20 delocalized electrons. We calculate a significant binding energy for the anionic Si@Au16/O2- complex and show that the adsorbed O2 is activated to a superoxo-s…
Atomic structure solution of the complex quasicrystal approximant Al77Rh15Ru8 from electron diffraction data
2014
The crystal structure of the novel Al77Rh15Ru8phase (which is an approximant of decagonal quasicrystals) was determined using modern direct methods (MDM) applied to automated electron diffraction tomography (ADT) data. The Al77Rh15Ru8E-phase is orthorhombic [Pbma,a= 23.40 (5),b= 16.20 (4) andc= 20.00 (5) Å] and has one of the most complicated intermetallic structures solved solely by electron diffraction methods. Its structural model consists of 78 unique atomic positions in the unit cell (19 Rh/Ru and 59 Al). Precession electron diffraction (PED) patterns and high-resolution electron microscopy (HRTEM) images were used for the validation of the proposed atomic model. The structure of the E…
Ion motion in salt water flowing under a transverse magnetic field
2012
The problem of ion motion in an electrolyte solution flowing in a thin rectangular duct with velocity VE in the presence of a transverse magnetic field B0 is studied by means of classical mechanics and electrodynamics. Because of Lorentz force on the ions in the electrolyte solution, a so called Faraday voltage appears at the electrodes orthogonal to both the field B0 and the velocity VE. The dynamics of positive and negative ions (cations and anions, respectively) in this classical system is studied by taking into account the viscosity of the fluid and the process of charge accumulation on the opposite walls of the duct. Hydrogen production is seen to take place at one of the electrodes wh…
IMMAGINARE GLI ITALO-AMERICANI: DALLA SCUOLA DI CHICAGO IN POI. INTRODUZIONE ALLA SEZIONE «CLASSICS»
2019
This piece introduces Chiara Mazzucchelli, Anthony Julian Tamburri, and Sabrina Vellucci’s essays on Italian-Americanness, and extracts from Irving L. Child and Harvey Warren Zorbaugh’s sociological studies on marginality and «vice» areas in the US of the early XX century. It frames these distinctive and insightful pieces within the context of identitarian, linguistic, and cultural struggles that make up the archives of Italian migrant communities in the US.In conversation with the five pieces, this introduction aims to inquire into the practices of stigmatisation and reproduction of violence by dominant epistemological and ontological frameworks travelling beyond borders.
Price Theory and US Antitrust: a Note on an Enduring Legal Doctrine
2013
Since the mid-1980s the post-Chicago approach to antitrust economics has produced a few game-theoretic models which have challenged many typical Chicago antitrust propositions. Yet, Chicago style antitrust has not yet lost its hold on u.s. antitrust. The paper suggests that the Chicago persistence within u.s. antitrust and, by the same token, the inhospitality of u.s. antitrust towards game-theoretical Industrial Organization theory owe much to the vitality of the legal doctrine according to which antitrust analysis should be consistent with traditional price theory. In particular, the paper analyzes two issues: i. the adoption of the equilibrium end-state notion of competition which is sti…
L’analyse de la criminalité à Chicago : de nouvelles perspectives offertes par l’économétrie spatiale à une question ancienne
2015
International audience