Search results for "CALL"

Time to Deterioration in Quality of Life Score as a Modality of Longitudinal Analysis in Patients with Breast Cancer

2011

Abstract Purpose. This prospective multicenter study explored different definitions of time to deterioration (TTD) in quality of life (QoL) scores, according to different cutoffs of the minimal clinically important difference (MCID) as a modality for longitudinal QoL assessment in breast cancer patients. Methods. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 and BR-23 before surgery, after surgery, and 6 and 12 months later. The global health score, arm symptoms score (BRAS), and breast symptoms score were analyzed. For a given baseline score, QoL was considered to have deteriorated if this score decreased by ≥5 point…

Cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas: Real-life experience from the French CAREPI study group

2021

Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%

Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines.

2013

Genetically modified cells have been shown to be one of the most effective cancer vaccine strategies. An evaluation is made of the efficacy of both preventive and therapeutic antitumor vaccines against murine melanoma, using C57BL/6 mice and irradiated B16 tumor cells expressing granulocyte and macrophage colony-stimulating factor (GM-CSF), interleukin-12 (IL-12) or both. Tumor was transplanted by the injection of wild-type B16 cells. Tumor growth and survival were measured to evaluate the efficacy of vaccination. Specific humoral response and immunoglobulin G (IgG) switch were evaluated measuring total IgG and IgG1 and IgG2a subtypes against tumor membrane proteins of B16 cells. In prevent…

Insights into Genetic Diversity, Runs of Homozygosity and Heterozygosity-Rich Regions in Maremmana Semi-Feral Cattle Using Pedigree and Genomic Data

2020

Semi-feral local livestock populations, like Maremmana cattle, are the object of renewed interest for the conservation of biological diversity and the preservation and exploitation of unique and potentially relevant genetic material. The aim of this study was to estimate genetic diversity parameters in semi-feral Maremmana cattle using both pedigree- and genomic-based approaches (FIS and FROH), and to detect regions of homozygosity (ROH) and heterozygosity (ROHet) in the genome. The average heterozygosity estimates were in the range reported for other cattle breeds (HE=0.261, HO=0.274). Pedigree-based average inbreeding (F) was estimated at 4.9%. The correlation was low between F and genomi…

2021

Abstract Remote sensing-based measurements of solar-induced chlorophyll fluorescence (SIF) are useful for assessing plant functioning at different spatial and temporal scales. SIF is the most direct measure of photosynthesis and is therefore considered important to advance capacity for the monitoring of gross primary production (GPP) while it has also been suggested that its yield facilitates the early detection of vegetation stress. However, due to the influence of different confounding effects, the apparent SIF signal measured at canopy level differs from the fluorescence emitted at leaf level, which makes its physiological interpretation challenging. One of these effects is the scatterin…

Remote sensing of sunlight-induced chlorophyll fluorescence and reflectance of Scots pine in the boreal forest during spring recovery

2005

A measurement campaign to assess the feasibility of remote sensing of sunlight-induced chlorophyll fluorescence (ChlF) from a coniferous canopy was conducted in a boreal forest study site (Finland). A Passive Multi-wavelength Fluorescence Detector (PMFD) sensor, developed in the LURE laboratory, was used to obtain simultaneous measurements of ChlF in the oxygen absorption bands, at 687 and 760 nm, and a reflectance index, the PRI (Physiological Reflectance Index), for a month during spring recovery. When these data were compared with active fluorescence measurements performed on needles they revealed the same trend. During sunny days fluorescence and reflectance signals were found to be str…

Grapevine physiological response to row orientation-induced spatial radiation and microclimate changes

2020

Terroir factors and vineyard practices largely determine canopy and root system functioning. In this study, changes in soil conditions, multi-level (vertical, horizontal) light interception (quantitative, photographic, schematic, 3D modelled), leaf water potential and photosynthetic activity were measured during the grape ripening period on NS, EW, NE-SW, and NW-SE orientated (Southern Hemisphere) vertically trellised Shiraz grapevine canopies. It was hypothesised that the spatial radiation interception angle and radiation distribution of differently orientated and vertically trained grapevine rows would affect soil conditions and vine physiological activity. Soil water content showed an in…

Caracalla e i Parti in Erodiano: fra disegno ecumenico e inganno

2020

La storia degli studi ha molto dibattuto sul progetto di matrimonio fra Caracalla e la figlia di Artabano, tramandata da Cassio Dione ed Erodiano, interrogandosi sulla sua veridicità con particolare riguardo alla versione di Erodiano, sulle motivazioni e sul contesto della successiva campagna partica allestita dall’imperatore. Una rilettura delle fonti mette in luce come la ricostruzione storica di Erodiano, di là dall’innegabile componente inventiva, doveva riflettere motivi utilizzati da Caracalla nella comunicazione ufficiale e ispirati al tema dell’ecumenismo, e al tempo stesso plasmare in termini fortemente ostili un’immagine dell’operato imperiale caratterizzato da slealtà e inganno, …

Caracalla e i filosofi

2016

Le testimonianze storiografiche relative al rapporto di Caracalla con i filosofi riflettono il giudizio più in generale negativo sull’imperatore. Centrale è la testimonianza di Cassio Dione sull’ostilità nei confronti dei filosofi aristotelici e sull’abolizione dei syssitia alessandrini, da inserire nel contesto del clima successivo all’assassinio di Geta e dell’eliminazione dei rivali politici. Dalla documentazione letteraria ed epigrafica emerge inoltre un interesse dell’imperatore per la filosofia teurgica (con particolare attenzione alla figura di Apollonio di Tiana), che le fonti letterarie intendono, talvolta deformando l’evidenza, come propen- sione verso la magia.

Caracalla: il doppio volto di un nome

2022

L’analisi della tradizione storiografica greca e di quella latina tardoantica sul soprannome imperiale Caracalla, legato alla veste di foggia barbarica introdotta dall’imperatore, indica due differenti spiegazioni dell’origine della denominazione, la prima legata agli eventi della campagna germanica del 213 ed alla successiva distribuzione alla plebs urbana delle vesti portate dalla spedizione, la seconda alla spedizione partica del 217 in occasione della quale l’imperatore avrebbe indossato un mantello ispirato a fogge barbariche. Le due tradizioni riflettono due originarie diverse connotazioni del soprannome, le quali tuttavia rispecchiano proprio le ambizioni ecumeniche dell’imperatore, …