Search results for "CANCERS"
showing 10 items of 276 documents
“Sick woman” or “half woman”? Breast and cervical cancer, emotional script and representations of female body in a mediterranean area of Italy
2016
The proposal aims to highlight the semiotic elements of the discourse that refer to the symbolic ones of representations, and that transform the therapy in an exercise of professional dominion aimed to modify the perception of the self of the female patient through the subversion of specific emotional script. The mapping of the emotional scripts of shame and modesty, in their performative evolution, will be useful to demonstrate how and through what relational strategies the medicalization performs a gender violence which leads to exclude and self-stigmatise the sick woman, considered a “half woman”. The reflection that has its incipit in the ascertainment that the female body has been and …
Navigation accuracy after automatic- and hybrid-surface registration in sinus and skull base surgery.
2016
Objective Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This study examined whether navigation accuracy can be improved in specific anatomical localizations by using hybrid registration technique. Study design Experimental phantom study. Setting Operating room. Subjects and methods The gold standard of screw registration was compared with automatic LED-mask-registration alone, and in combination with additional surface matching. 3D-printer-based skull models with individual fabricated silicone skin were u…
Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas:…
2020
Background In the photodynamic therapy (PDT) of non‐aggressive basal cell carcinomas (BCCs), 5‐aminolevulinic acid nanoemulsion (BF‐200ALA) has shown non‐inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this is the first study using HAL‐PDT in the treatment of BCCs. Objectives To compare the histological clearance, tolerability (pain and post‐treatment reaction), and cosmetic outcome of MAL, BF‐200 ALA, and low‐concentration HAL in the PDT of non‐aggressive BCCs. Methods Ninety‐eight histologically verified non‐aggressive BCCs met the inclusion criter…
Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes
2013
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segments. A recent whole genome sequencing effort yielded no frequently recurring mutations in genes other than those affecting ALK. However, the study further stresses the importance of DNA copy number alterations in this disease, in particular for genes implicated in neuritogenesis. Here we provide additional evidence for the importance of focal DNA copy number gains and losses, which are predominantly observed in MYCN amplified tumors. A focal 5 kb…
2-Hydroxyoleic Acid Induces ER Stress and Autophagy in Various Human Glioma Cell Lines
2012
Background: 2-Hydroxyoleic acid is a synthetic fatty acid with potent anti-cancer activity which does not induce undesired side effects. However, the molecular and cellular mechanisms by which this compound selectively kills human glioma cancer cells without killing normal cells is not fully understood. The present study was designed to determine the molecular bases underlying the potency against 1321N1, SF-767 and U118 human glioma cell lines growth without affecting non cancer MRC-5 cells. Methodology/Principal Findings: The cellular levels of endoplasmic reticulum (ER) stress, unfolded protein response (UPR) and autophagy markers were determined by quantitative RT-PCR and immunoblotting …
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
2011
BackgroundPeriostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data s…
Olive oil intake and cancer risk: A systematic review and meta-analysis
2022
Background Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis. Methods A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed. Results 45…
To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic
2020
PLOS ONE 15(9), e0239027 (2020). doi:10.1371/journal.pone.0239027
Activité physique : Prévention et traitement des maladies chroniques
2019
Les maladies chroniques sont des affections non transmissibles de longue durée, parfois permanentes, qui évoluent avec le temps. Selon l’OMS, elles sont la première cause de mortalité mondiale et en Europe elles "concourent à près de 86% des décès […] et pèsent de plus en plus lourdement sur les systèmes de santé, le développement économique et le bien-être d’une grande partie de la population, en particulier chez les personnes âgées de 50 ans et plus".En France, la part des personnes âgées de 60 ans et plus devrait passer d’un quart en 2015 à un tiers de la population en 2040. Actuellement, c’est un français sur quatre qui souffre d’une maladie chronique, trois sur quatre après 65 ans. Ave…
Expression of Heat Shock Protein in bladder cancers.
2005
Expression of Heat Shock Protein in bladder cancers.