Search results for "CANNABIS"
showing 10 items of 174 documents
Tobacco, Cannabis, and Other Illicit Drug Use Among Finnish Adolescent Twins: Causal Relationship or Correlated Liabilities?*
2010
Contains fulltext : 90566.pdf (Publisher’s version ) (Open Access) Objective: Among Finnish adolescent twins, we compared (a) a model that describes a direct impact of liability to tobacco use on cannabis and other illicit drug use with (b) a model that included a shared underlying liability for these substances. Furthermore, the extent to which genetic and environmental influences contribute to the covariation between liabilities to use these substances was examined. Method: Tobacco and illicit drug use were assessed at age 17.5 years. Twin data on 3,744 individuals were analyzed using standard biometrical methods. Two alternative multivariate models were fit and compared with Mx, a statis…
Adverse effects of heavy cannabis use: even plants can harm the brain.
2020
The spread of laws legalising cannabis for medicinal or recreational use has been accompanied by more relaxed attitudes towards cannabis. Data from the United States show that in states that have legalised cannabis, prevalence of daily, weekly, and monthly cannabis use was 11.3%, 18.3%, and 25.0% respectively, whereas in countries where it is still illegal, it was lower (7.4%, 11.6%, and 16.8% respectively). Evidence indicates a trend of increase among adolescents, a particular vulnerable category for the initiation of substance use. In parallel, we have seen the concentration of THC (D-9-tetrahydrocannabinol) in the cannabis sold both in the United States and in Europe rising and those typ…
Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: The EU-GEI case-control study
2021
The work was supported by: Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust to DQ; DFG Heisenberg professorship (no. 389624707) to UR. National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by t…
The most 100 cited papers in addiction research on cannabis, heroin, cocaine and psychostimulants. A bibliometric cross-sectional analysis
2021
The number of citations a peer-reviewed article receives is often used as a measure of its importance and scientific impact. This paper identifies, describes and categorizes the highly cited papers in addiction research on cannabis, heroin, cocaine and psychostimulants. Highly cited papers were identified in the Web of Science Core Collection database. Several bibliometric indicators were calculated. Social network analysis was applied to draw groups of authors and institutions with the greatest number of collaborations and co-words. The number of citations for the top 100 cited articles ranged from 649 to 4,672. The articles were published in 40 journals. The subject category Substance Abu…
Substance use, medication adherence and outcome one year following a first episode of psychosis
2016
Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset signific…
Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals
2021
Background To evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models. Material and methods We carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object. Results A total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of J…
FIRST EPISODE PSYCHOTIC PATIENTS WITH A HISTORY OF FREQUENT CANNABIS USE EXPRESS MORE POSITIVE SYMPTOMS AT ILLNESS ONSET THAN THOSE WHO NEVER USED CA…
2018
Background: Robust evidence has demonstrated that cannabis use increases the risk to develop psychotic disorders. However, a limited number of studies have investigated if and how cannabis use influences psychopathology profiles at first episode psychosis (FEP). Based on the evidence that dopamine dysfunction contributes to explain positive symptoms in psychosis, and that the main cannabis’ psychoactive component, Δ9-Tetrahydrocannabinol (THC), modulates the dopamine system, we hypothesise that: 1) positive symptoms at FEP are more common among psychotic patients who used cannabis compared with never users; 2) this association is a dose-response relationship. Methods: We analyzed a sample o…
Better IQ but worse Premorbid Academic Adjustment in cannabis-users psychotic patients: another brick in the intuition
2016
Purpose: several studies report that patients with psychosis who used cannabis in their lifetime have a better cognitive performance than those who did not and this association is most likely due to a better premorbid functioning. We aimed to test the hypothesis of a better premorbid functioning in First Episode Psychosis (FEP) cannabis-using and non-using patients coming from different European countries. Materials and Methods: 1.745 people (746 cases; 999 healthy controls) completed the assessment for Intellectual Quotient (IQ) (WAIS-brief version) premorbid adjustment (Premorbid Adjustment Scale – PAS) and cannabis use (CEQ-Revised). We first obtained two main factors from PAS: “Premorbi…
Sport-related acute myocardial infarction; Context of onset and one-year follow-up
2021
Background Sport-related (SR) acute coronary events are the main cause of sudden cardiac in the setting of sport activities; data are very scarce regarding the context of onset and the follow-up of SR acute myocardial infarction (AMI). Methods We prospectively invited subjects admitted in our University Hospital from April 2018 for a SR-AMI to participate in the IMACS observatory program which addresses to SR-AMI including a 12 months follow-up. Results From April 2018 to April 2019, 21 subjects were included. The mean age of this male population was 57.5 ± 11.0 (median 56). The context of event was available for 21 (provided by family for a subject with out of hospital (OH) SCA). Sport was…
La productividad científica en drogodependencias desde las revistas específicas
2011
From general population surveys and specific studies data, an epidemiological description is offered. Since 1994, the year of the fi rst Spanish school survey, until 2008, in all temporal references alcohol use trend was slightly decreasing for both boys and girls, though less for girls that showed somewhat higher prevalences in recent years. Drunkenness prevalence trend among those students drinking alcohol during the last 30 days has increased and was higher for boys. For cannabis and cocaine there was an increasing trend until 2004; trends for ecstasy and hallucinogens were less marked towards lower prevalences in recent years; all of them were higher in boys. Girls had higher prevalence…