Search results for "CAP"
showing 10 items of 8832 documents
Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes
2021
Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear neutrophil granulocytes (PMN) express high levels of arginase 1 and can act as suppressor cells of adaptive anti-cancer immunity. Here we demonstrate that pharmacological inhibition of PMN-derived arginase 1 not only prevents the suppression of T cell functions but rather leads to a strong hyperactivation of T cells. Human PMN were incubated in cell culture medium in the absence or presence of an arginase inhibitor. T cells from healthy donors w…
Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…
La complejidad social de la discapacidad. Algunos ejemplos de la narración fílmica
2010
Abordar la discapacidad desde una perspectiva multidisciplinar, que recurre a la narración fílmica como método de análisis, puede ayudar a indicar la noción adecuada en referencia a esta realidad dentro de la complejidad terminológica y conceptual existente a nivel jurídico-social. Son muchas las denominaciones utilizadas, y éstas han ido variando en función de los cambios de paradigma en la materia. Se han distinguido tres modelos de tratamiento que, a su vez, han ido apareciendo en la narración fílmica: el tradicional, el médico y el social. Se enfatiza este último ya que entiende la discapacidad como el conjunto de desventajas que el individuo con deficiencias sufre cuando el entorno es…
Bibliometric Research in Technology-Mediated Learning with High Capacity Students
2020
RESUMEN: Este trabajo implica una revisión del trabajo de investigación sobre el aprendizaje mediado por tecnología en estudiantes de alta capacidad. El estudio fue realizado por medio de un análisis bibliométrico de la producción científica en la renombrada base de datos Scopus. Fueron evaluados, sin filtro temporal, 35 artículos publicados entre 1993 y 2018, de los cuales se analizó una selección de indicadores de productividad científica, colaboración, consumo e impacto, así como variables estructurales y de contenido. Aunque el número de artículos no sea muy alto, los resultados mostraron un aumento en las publicaciones científicas recientes centradas en procesos de aprendizaje mediados…
The Linguistic Landscape of the Valencian Community: A Comparative Analysis of Bilingual and Multilingual Signs in Three Different Areas
2019
During the last decades, the promotion of multilingualism has been key when designing linguistic policies in Europe. Previous research studies have focused on how languages are employed in fields such as education, media, and urban sites, among others. Bearing all this in mind, the aim of this paper is to analyse the linguistic landscapes of three municipalities located in a bilingual region in Spain, that of the Valencian Community. Thus, issues such as language contact, language dominance, and the languages used by a number of institutions on private and public signs were examined. As for the method, over 140 pictures of language signs were taken in order to examine language contact, lang…
Pleasurable and Intersubjectively Embodied Experiences of Electronic Dance Music
2016
How do dancers engage with electronic dance music (EDM) when dancing? This paper reports on an empirical study of dancers' pleasurable engagement with three structural properties of EDM: (1) breakdown, (2) build-up, and (3) drop. Sixteen participants danced to a DJ mix in a club-like environment, and the group’s bodily activity was recorded with an infrared, marker-based motion capture system. After they danced, the subjects filled out questionnaires about the pleasure they experienced and their relative desire to move while dancing. Subsequent analyses revealed associations between the group’s quantity of motion and self-reported experiences of pleasure. Associations were also found betwee…
Measuring Aksak Rhythm and Synchronization in Transylvanian Village Music by Using Motion Capture
2015
<p>Techniques based on motion capture can be useful in <span><span style="font-size: x-small;">analyzing a wide range of musical styles and practices</span></span>: in this case, Transylvanian village music. We focused on a repertoire known as “Gypsy songs of sorrow”, played by professional Gypsy musicians during parties and celebrations of their own community. Two parameters were the object of study: rhythmic duration, and synchronization between musicians (a violinist and a viola player). Results show that rhythm is a local variant of <em>aksak</em> and is based on two duration units (S=short, L=long) which respect the formula 2:3 &lt; S:L &am…
Conceptualizing innovation capabilities: A contingency perspective
2017
Empirical research has confirmed that a positive relationship exists between the implementation of innovation activities and the future performance of organizations. Firms utilize resources and capabilities to develop innovations in the form of new products, services or processes. Some firms prove to be better at reproducing innovation success than others, and the capacity to do so is referred to as innovation capability. However, the term innovation capability is ambiguously treated in extant literature. There are several different definitions of the concept and the distinction between innovation capabilities and other types of capabilities, such as dynamic capabilities, is neither explici…
High-resolution orthophoto map and digital surface models of the largest Argentine Islands (the Antarctic) from unmanned aerial vehicle photogrammetry
2020
This study presents the first high-resolution orthophoto maps and digital surface models (DSMs) of the largest Argentine Islands, West Antarctica. Aerial surveys with small unmanned aerial vehicle (UAV) were performed in Austral summer, 2018, taking 10,041 aerial photographs. Accuracy requirements were ensured using ground control points (GCPs). A resolution of 3.4 and 6.8 cm/px of orthomosaics and DSMs is reached on average, and the RMS reprojection error is 0.22 m on average. We report the morphometric parameters of surveyed islands and discuss issues related to accuracy and the usage of UAVs in polar conditions. This study demonstrates that small and low cost UAVs can be successfully use…
A web-based collection of genotype-phenotype associations in hereditary recurrent fevers from the Eurofever registry
2017
PubMed ID: 29047407