Search results for "CAP"
showing 10 items of 8832 documents
Structural characterization of site-modified nanocapsid with monodispersed gold clusters
2017
AbstractHepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the present study, the nanocapsid surface was modified with a solvent-exposed cysteine to conjugate monolayer protected gold nanoclusters (AuNC). Unlike commercially available gold nanoparticles, AuNCs monodisperse in water and are composed of a discrete number of gold atoms, forming a crystalline gold core. Au102pMBA44 (Au102) was an ideal conjugate given its small 2.5 nm s…
Retention forestry and biodiversity conservation: a parallel with agroforestry
2013
In forested landscapes two general management systems – retention forestry and agroforestry – have been proposed as potentially efficient components of landscape approaches to ease the conflict between biodiversity objectives and human needs. In two recent reviews, Gustafsson et al. (2012) and Lindenmayer et al. (2012) provide a global overview of current knowledge about the practice and ecological roles of retention forestry. A few years ago, Bhagwat et al. (2008) produced a similar review addressing the role of agroforestry in biodiversity conservation. Here we draw a parallel between research on the ecological effects of retention forestry and agroforestry. We argue that conservation sci…
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
Comparative ultrastructure and carbohydrate composition of gastroliths from Astacidae, Cambaridae and Parastacidae freshwater crayfish (Crustacea, De…
2012
21 pages; International audience; Crustaceans have to cyclically replace their rigid exoskeleton in order to grow. Most of them harden this skeleton by a calcification process. Some decapods (land crabs, lobsters and crayfish) elaborate calcium storage structures as a reservoir of calcium ions in their stomach wall, as so-called gastroliths. For a better understanding of the cyclic elaboration of these calcium deposits, we studied the ultrastructure of gastroliths from freshwater crayfish by using a combination of microscopic and physical techniques. Because sugars are also molecules putatively involved in the elaboration process of these biomineralizations, we also determined their carbohy…
Risk of Periodontal Disease: Is there a Correlation with the Type of Antihypertensive Medication?
2011
Introduction: The purpose of this study was to evaluate the effects of long-term oral antihypertensive treatment using centrally acting sympatho-inhibitory drugs (clonidine) and beta-blockers (metoprolol) on capillary microcirculation in the labial and periodontal mucosa.
 Methods: Sixty subjects were recruited for the study: 20 patients affected by hypertension in treatment with centrally-acting sympatho-inhibitory drugs (64.28 ± 11.78 years); 20 patients in treatment with beta-blockers (62.03 ± 9.84 years) and 20 healthy subjects (62.06 ± 6.72 years). We use the videocapillaroscopic technique to evaluate in vivo the microcirculation of the labial mucosa corresponding to the lower lip…
Do native white-clawed crayfish impact macroinvertebrate assemblages in Mediterranean limestone headwaters?
2019
Crayfish are among the largest aquatic macroinvertebrates in rivers and streams. Their trophic ecology is important for the understanding of the functioning of benthic communities. This is relevant in key areas, such as headwaters, as they partly condition the processes occurring downstream. To shed light on the effects of native white-clawed crayfish,Austropotamobius pallipes, on local macroinvertebrate assemblages from running headwaters, a three-month mesocosm-based field study was designed. Collection and subsequent analysis of benthic samples under different crayfish density levels yielded a set of metrics indicative of short-term impacts at general and taxonomic scales. Neither signif…
Spectrofluorimetric study of dissolved organic matter in River Salaca (Latvia) basin waters
2012
Dissolved organic matter (DOM) in surface waters influences mineral weathering, nutrient cycling, aggregation of particulate matter and photochemical reactions in waters and aquatic communities. In this study, the effectiveness of UV and fluorescence measurements in distinguishing the origin of DOM and processes within the river basin were analyzed using the River Salaca basin as an example. The basin of River Salaca is characterized by low anthropogenic pressure, however, the water color during the last few decades has increased (an effect known as brownification). As tools to study the composition of dissolved organic substances in waters of the River Salaca and its tributaries the use of…
Invasive crayfish increase habitat connectivity: a case study in a large boreal lake
2013
Several studies have shown that distinct compartments of lake ecosystems are coupled via transportation of organic matter, nutrients and energy across habitat boundaries. Here we evaluate the potential of the invasive signal crayfish (Pacifastacus leniusculus (Dana)) to modify energy pathways in large boreal lakes. Using a stable isotope mixing model and calculation of the isotopic niches we estimated the contribution of different food sources to the diets of crayfish captured from different habitats, and from that inferred their potential to transport energy across the littoral-profundal gradient. The crayfish caught from the littoral area utilized mainly littoral food sources, whereas the…
Fomentar la resiliencia en familias con enfermedades crónicas pediátricas
2013
En este artículo se describen los diferentes enfoques que se pueden aplicar al estudio del concepto de resiliencia familiar en el contexto de las enfermedades crónicas pediátricas y sus implicaciones en la práctica clínica y educativa. Asimismo, se describen los principios generales que deben regir esta práctica y las actuaciones concretas de los profesionales de los sistemas sanitarios, educativos y sociales. La resiliencia familiar es imprescindible para mantener una buena calidad de vida del niño enfermo y de la familia en su conjunto.
Why the share of small amount pensions is so substantial in Latvia?
2018
More than 70% of all old-age pensions in Latvia are smaller than 300 euro, which is close to the monetary value of the at-risk-of-poverty threshold. There is a number of reasons for it: the lack of non-contributory component and inadequately low minimum pensions, the absence of redistribution mechanisms in the mandatory notional defined contribution (pillar I) and funded (pillar II) schemes, an unfair conversion of pre-reform employment record into pension formula, and a high tax burden on pensioners. The authors proposed a package of measures to improve the situation: an introduction of basis pensions, linking minimum pensions to the country average wages, increasing income tax exempt for …