Search results for "CAP"
showing 10 items of 8832 documents
Nitric oxide and sensory afferent neurones modulate the protective effects of low-dose endotoxin on rat gastric mucosal damage
1995
Pretreatment (1 h) with low doses (5-40 micrograms/kg i.p.) of Escherichia coli endotoxin dose dependently reduced the gastric mucosal damage induced by a 10 min challenge with 1 ml ethanol (50% and 100%) in conscious rats. Treatment with the nitric oxide synthesis inhibitor, NG-nitro-L-arginine methyl ester (L-NAME, 5 and 10 mg/kg i.p.), significantly inhibited the protective effects of endotoxin (40 micrograms/kg i.p.). The actions of L-NAME were reversed by the prior administration of L-arginine (100 mg/kg i.p.). The protective effects of endotoxin were not influenced by pretreatment with dexamethasone (5 mg/kg s.c. twice) or indomethacin (5 mg/kg s.c.). However, ablation of sensory affe…
Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing th…
2015
Enhancing delivery of antigens to dendritic cells (DCs) is essential for the induction of vigorous antigen-specific cellular immune responses. Aim of the present study was to evaluate the properties of hydroxyethyl starch nanocapsules (HES-NCs) functionalized with anti-CD40, anti-DEC205, interferon-γ (IFNγ) and/or monophosphoryl lipid A (MPLA) with respect to the overall uptake, the released cytokine profile, and the influence on phenotypic maturation of human monocyte-derived DCs using flow cytometry, confocal microscopy and enzyme-linked immunosorbent assays. NC uptake by DCs was significantly enhanced by functionalizing NCs with anti-CD40 or MPLA. With respect to the cytokine profile and…
Encapsulation of Vitamins A and E as Spray-Dried Additives for the Feed Industry
2020
Encapsulated fat-soluble powders containing vitamin A (VA) and E (VE) were prepared as a feasible additive for extruded feed products. The effect of the encapsulating agents (Capsul-CAP®
Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma
2017
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive tumor originating from the epithelial lining of the upper aero-digestive tract accounting for 300,000 annual deaths worldwide due to failure of current therapies. The natural killer group 2D (NKG2D) receptors on natural killer (NK) cells and several T cell subsets play an important role for immunosurveillance of HNSCC and are thus targeted by tumor immune evasion strategies in particular by shedding of various NKG2D ligands (NKG2DLs). Based on plasma and tumor samples of 44 HNSCC patients, we found that despite compositional heterogeneity the total plasma level of NKG2DLs correlates with NK cell inhibitio…
Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4
2014
Abstract Cancer-initiating cells (CICs) that are responsible for tumor initiation, propagation, and resistance to standard therapies have been isolated from human solid tumors, including colorectal cancer (CRC). The aim of this study was to obtain an immunological profile of CRC-derived CICs and to identify CIC-associated target molecules for T cell immunotherapy. We have isolated cells with CIC properties along with their putative non-CIC autologous counterparts from human primary CRC tissues. These CICs have been shown to display “tumor-initiating/stemness” properties, including the expression of CIC-associated markers (e.g., CD44, CD24, ALDH-1, EpCAM, Lgr5), multipotency, and tumorigenic…
Castello di Capo d'Orlando
2001
scheda di catalogo del castello di Capo d'Orlando
Castello di Capizzi
2001
scheda di catalogo del castello di Capizzi
Pensamiento crítico y su impacto en el desempeño del proyecto de mejora continua
2022
¿Cómo influye el pensamiento crítico (PC) en el desempeño del proyecto de mejora continua (MC), considerando mediación de las capacidades dinámicas (CDs) que subyacen en dicho proyecto? Guiados por tal interrogante general, la tesis cubre tres aspectos. El primero se centra en la conceptualización y operativización del PC en la organización, bajo un marco de MC, lo cual redunda en el diseño y validación psicométrica de un modelo de medida al respecto. El segundo presenta el mismo alcance que el primero, pero esta vez comprende el constructo CDs del proyecto de MC. El tercero se orienta al contraste empírico de la relación estructural entre PC, CDs y desempeño del proyecto, usando analítica/…
Mejora de los procesos cognitivos y discapacidad intelectual
2006
Se describen las principales dificultades en los procesos cognitivos básicos (percepción, atención, memoria, procesos ejecutivos) y las actividades y programas para mejorarlos. Asimismo, se describen las dificultades de algunos síndromes que cursan discapacidad intelectual.
Neuropsicología y discapacidad intelectual
2006
Se describen las bases neurológicas de la percepción, atención, memoria, comportamiento motor, procesos ejecutivos, pensamiento y emociones y los trastornos asociados.