Search results for "CAPE"

Lactate: A Metabolic Key Player in Cancer

2011

Abstract Increased glucose uptake and accumulation of lactate, even under normoxic conditions (i.e., aerobic glycolysis or the Warburg Effect), is a common feature of cancer cells. This phenomenon clearly indicates that lactate is not a surrogate of tumor hypoxia. Tumor lactate can predict for metastases and overall survival of patients, as shown by several studies of different entities. Metastasis of tumors is promoted by lactate-induced secretion of hyaluronan by tumor-associated fibroblasts that create a milieu favorable for migration. Lactate itself has been found to induce the migration of cells and cell clusters. Furthermore, radioresistance has been positively correlated with lactate…

Short- and Long-Term Quality of Life and Bowel Function in Patients With MRI-Defined, High-Risk, Locally Advanced Rectal Cancer Treated With an Inten…

2015

Objective Intensified preoperative treatments have been increasingly investigated in locally advanced rectal cancer (LARC), but limited data are available for the impact of these regimens on quality of life (QoL) and bowel function (BF). We assessed these outcome measures in EXPERT-C, a randomized phase 2 trial of neoadjuvant capecitabine combined with oxaliplatin (CAPOX), followed by chemoradiation therapy (CRT), total mesorectal excision, and adjuvant CAPOX with or without cetuximab in magnetic resonance imaging-defined, high-risk LARC. Methods and Materials QoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR29 questionnaires. Bowel inc…

A French prospective pilot study for identifying dihydropyrimidine dehydrogenase (DPD) deficiency in breast cancer patients (pts) receiving capecitab…

2013

e13519 Background: For fluoropyrimidines, and especially cap, Health Authorities point out that DPD deficiency confers a significant risk of major toxicity (tox). Identification of at-risk pts is thus relevant. This multicentric prospective study of the French GPCO group (Groupe de Pharmacologie Clinique Oncologique, Unicancer) evaluated the sensitivity, specificity and predictive values of DPD phenotyping and genotyping for predicting severe cap-related tox in metastatic breast cancer pts. Methods: 303 pts were included (15 institutions), 88% received cap as monotherapy, 28% were treated as first line (mean dose at 1st cycle 1957 mg/m2/d). Pre-treatment dihydrouracil (UH2) and uracil (U) …

Relationship between recruitment and mother plant vitality in the alien species Acacia cyclops A. Cunn. ex G. Don

2014

Acacia cyclops is a widespread invader in Mediterranean-climate regions. However, although its naturalization in the Mediterranean Basin dates back only a few years ago, and the invasion process has not been studied hitherto. We investigated seedlings recruitment strategy adopted by A. cyclops in a small island (Lampedusa, Italy) where its natural regeneration was strictly confined under mother plants canopy. Healthy plants (DCP), plants at incipient senescence (SCP) and dead plants (DP) were distinguished according to vitality and canopy status. Living plants were also characterized in relation to leaf C and N isotope composition. Regeneration pattern (seedlings and saplings abundance) was…

Patterns of algal recovery and small-scale effects of canopy removal as a result of human trampling on a Mediterranean rocky shallow community.

2004

The ecological importance of marine algae is widely known but in shallow coastal areas the composition and structure of algal communities may be affected by different human activities. Recovery from different trampling disturbances of two competing morphological groups (i.e. macroalgae and algal turfs) and effects of macroalgal canopy removal on the dominant associated fauna were examined using controlled trampling experiments. Six months after trampling disturbance was removed, the two morphological groups closely resembled control (untrampled) conditions, both in terms of cover and canopy (%). In particular, macroalgal recovery seemed to be very rapid: the higher the impact on the system …

Effects of spatial scale and vegetation cover on predation of artificial ground nests

1995

Scale-dependent effects of landscape heterogeneity on predation of artificial ground nests were studied. Two spatial scales were selected: landscape grain size and single stand size. The landscape types did not differ from each other in their total predation intensity. Depredation was highest in larger stands in all the landscape types studied and the highest predation rate was detected in the largest stands within the most fragmented landscapes. This is possibly due to concentration of rodent-eating predators from surrounding open areas into large stands in the study year when their main prey, voles, crashed. In crash years, alternative predation on e.g. forest bird nests may play an impor…

Oxygen isotopes in single micrometer-sized quartz grains: tracing the source of Saharan dust over long-distance atmospheric transport

2002

Abstract Oxygen isotope compositions were measured by ion microprobe in individual micrometer-sized quartz grains extracted from one aerosol sample collected on the Cape Verde Islands and from four surface samples (three soils and one sediment) representing potential source regions of aerosols in Western and Central Africa (Morocco, Algeria, Niger, and Chad). A large range of δ18O values, from +6.2‰ to +39.3‰ is present within the aerosol quartz grains. The different size fractions of the quartz grains from the surface samples overlap nearly entirely this range but show significant differences in their δ18O distributions for the different size fractions of the grains (i.e., different modes,…

Dynamics and Predictability of a Heavy Dry-Season Precipitation Event over West Africa—Sensitivity Experiments with a Global Model

2009

Abstract In January 2002 the Cape Verde region in tropical West Africa was hit by an exceptionally heavy precipitation event. Rain rates of up to 116 mm (48 h)−1 caused harmful impacts on the local population. The rainfall was triggered by a series of two upper-level disturbances penetrating from the extratropics to the West African coast. This study investigates the dynamics and predictability of this event on the basis of simulations with the global model Global Model Europe (GME) of the German Weather Service [i.e., Deutscher Wetterdienst (DWD)] initialized by the European Centre for Medium-Range Weather Forecasts (ECMWF) analysis data. Free forecasts satisfactorily reproduce the upper-l…

A multivariate approach to the feeding ecology of the Channel flounder, Syacium micrurum (Pisces, Pleuronectiformes), in Cape Verde, Eastern Atlantic

2009

The feeding ecology of the Channel flounder, Syacium micrurum, from Cape Verde was studied in November 2003 and April 2004, using frequency of occurrence and percentage by number indices, as well as multivariate analyses. Overall, S. micrurum exhibited a generalist feeding strategy with a relatively broad niche width. Analyses indicated Crustacea (especially Brachyura) and Polychaeta as the dominant prey items, although other items, such as Foraminifera, Caridae or Actinopterigii, were preyed on more often or in larger quantities, depending on the sampling date. An ontogenetic shift in diet was also observed with smallsized individuals mostly consuming Crustacea, whereas medium- or large-si…

Michael Angelus Bonarotus pinxit, Adam Sculptor Mantuanus incidit.

Tít. pres del f. 1 Grav. calc.: "A.S."