Search results for "CARDIOVASCULAR DISEASE."
showing 10 items of 2331 documents
Comparación de las frecuencias de los alelos factor V Leiden (G1691A) y protrombina-G20210A entre pacientes con trombosis venosa profunda y población…
2006
Background: Factor V leiden and the -G20210A variant of prothrombin gene are associated to a higher risk of deep venous thrombosis. Aim: To assess the frequency of factor V Leiden (G1691A) and prothrombin -G20210A alleles in patients with deep venous thrombosis (DVT) and in the general population from Spain. Material and methods: Factor V Leiden (g1691a) and prothrombin-g20210a alleles were genotyped in 493 individuals from the Spanish general populations and in 131 patients with DVT. The presence of DVT was confirmed by phlebography. Allelic frequencies and the DVT risk associated with these variants were estimated. Results: Allelic frequencies for the factor V Leiden (G1691A) allele were …
Evaluation of atrial function by 2D strain echocardiography in patients with atrial fibrillation
2012
Abstract Objectives To evaluate atrial function by 2D strain in patients with atrial fibrillation (AF) and normal or slightly increased atrial size and to verify whether lower atrial strain is associated with more frequent AF recurrences. Materials and methods We studied 50 patients with AF, mean age 59.6 ± 13 years and 50 age-and gender-matched controls. We analyzed left atrial function through 2Dstrain imaging, after the re-establishment of sinus rhythm (SR) and we investigated about the recurrences of the arrhythmia. Results Atrial strain (AS) was lower in AF patients vs controls (LA p Conclusions The assessment of atrial function by strain imaging might help to identify patients who nee…
Effect of low-dose aspirin on health outcomes: An umbrella review of systematic reviews and meta-analyses.
2020
Aims:\ud \ud This study aimed to use an umbrella review methodology to capture the range of outcomes that were associated with low‐dose aspirin and to systematically assess the credibility of this evidence.\ud \ud Methods:\ud \ud Aspirin is associated with several health outcomes, but the overall benefit/risk balance related to aspirin use is unclear. We searched three major databases up to 15 August 2019 for meta‐analyses of observational studies and randomized controlled trials (RCTs) including low‐dose aspirin compared to placebo or other treatments. Based on random‐effects summary effect sizes, 95% prediction intervals, heterogeneity, small‐study effects and excess significance, signifi…
Cross-Sectional Associations between HDL Structure or Function, Cell Membrane Fatty Acid Composition, and Inflammation in Elderly Adults.
2022
Background Cell membrane fatty acid composition has been related to inflammation and cardiovascular risk. Dysregulation of HDL functionis also considered a cardiovascular risk factor. Objective We aimed to investigate whether the content of cell membrane fatty acids and HDL functionality are linked to each other as well as to inflammation. Methods This cross-sectional analysis involved 259 participants (67.9 y) with overweight/obesity (body mass index 29.5 kg/m2) from a coronary heart disease case-control study nested within the PREDIMED trial for which HDL functional parameters (Apolipoproteins (Apo) A-1, A-IV and C-III, cholesterol efflux capacity (CEC), HDL oxidative inflammatory index (…
Mental disorders and cardiovascular disease: what should we be looking out for?
2021
### Learning objectives Mental disorders are prevalent. They impair patients’ quality of life severely and are associated with an increased risk of developing cardiovascular disease (CVD) and worse prognosis.1–4 Although these facts have been well established, there is still a gap in diagnostic awareness and treatment of mental disorders in patients with CVD.5–8 Therefore, we aim to educate cardiologists about the importance of mental disorders and how to address the widely unmet healthcare needs of patients with a mental disorder in their clinical practice. ### Mental disorders increase the risk for subsequent CVD All mental disorders are associated with an increased risk of developing CVD…
Urinary Albumin Excretion
2005
During the past few years, a subtle increase in urinary albumin excretion (UAE) not detectable by routine methods, microalbuminuria, has become a prognostic marker for cardiovascular and/or renal risk in diabetic and nondiabetic subjects. Consequently, microalbuminuria assessment is now recommended in a risk stratification strategy not only in diabetic subjects but also for hypertension management. Microalbuminuria is defined as UAE from 30 to 300 mg/24 hours or equivalent amounts using timed overnight or spot urine samples (Table). The definition comes from studies that have established its value as a marker of risk for nephropathy in diabetic subjects. When the potential prognostic value …
COVID-19 y enfermedad cardiovascular y renal: ¿Dónde estamos? ¿Hacia dónde vamos?
2020
La pandemia SARS-CoV-2 es una emergencia sanitaria global y necesitamos conocer más sobre ella. Los pacientes con riesgo cardiovascular y renal previo se han identificado como especialmente vulnerables para una mayor morbimortalidad cuando sufren la COVID-19, y una proporción considerable de pacientes pueden desarrollar una lesión vascular en el contexto de la enfermedad que conlleva una mayor letalidad. Las complicaciones cardiovasculares y renales representan un problema, y es probable que en un futuro próximo puedan suponer una amenaza para los pacientes que han sobrevivido a la COVID-19. Como médicos no podemos olvidar que durante una epidemia como esta otras enfermedades ----crónicas--…
An overview of new pharmacological treatments for cerebrovascular dysfunction after experimental subarachnoid hemorrhage
2004
Cerebral vasospasm and the resulting cerebral ischemia occurring after subarachnoid hemorrhage (SAH) are still responsible for the considerable morbidity and mortality in patients affected by cerebral aneurysms. Mechanisms contributing to the development of vasospasm, abnormal reactivity of cerebral arteries and cerebral ischemia after SAH have been intensively investigated in recent years. It has been suggested that the pathogenesis of vasospasm is related to a number of pathological processes, including endothelial damage, smooth muscle cell contraction resulting from spasmogenic substances generated during lyses of subarachnoid blood clots, changes in vascular responsiveness and inflamma…
CAD Modeling for Evaluating LVOT Obstruction in Transcatheter Mitral Valve Replacement
2019
The current generation of transcatheter heart valves (THV), as the Edwards SAPIEN 3 Ultra (S3), is not specifically designed for mitral position implantation and has intrinsic design geometry that may make mitral implantation suboptimal. This study aimed to develop a computed-tomography (CT) based CAD workflow for the preoperative planning of transcatheter mitral valve replacement (TMVR) by evaluating the resulting obstruction in the left ventricular outflow tract (LVOT). Specifically, the computational framework to reconstruct heart anatomy and virtually deploy the THV into mitral valve annulus was developed and successively applied to the cases of two patients who experienced annuloplasty…
Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with an…
2020
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