Search results for "CASCADES"
showing 5 items of 35 documents
Atmospheric effects on extensive air showers observed with the Surface Detector of the Pierre Auger Observatory
2009
Atmospheric parameters, such as pressure (P), temperature (T) and density (ρ ∝ P/T), affect the development of extensive air showers initiated by energetic cosmic rays. We have studied the impact of atmospheric variations on extensive air showers by means of the surface detector of the Pierre Auger Observatory. The rate of events shows a ∼ 10% seasonal modulation and ∼ 2% diurnal one. We find that the observed behaviour is explained by a model including the effects associated with the variations of P and ρ. The former affects the longitudinal development of air showers while the latter influences the Molière radius and hence the lateral distribution of the shower particles. The model is val…
Zenith distribution and flux of atmospheric muons measured with the 5-line ANTARES detector
2010
The ANTARES high energy neutrino telescope is a three-dimensional array of about 900 photomultipliers distributed over 12 mooring lines installed in the Mediterranean Sea. Between February and November 2007 it acquired data in a 5-line configuration. The zenith angular distribution of the atmospheric muon flux and the associated depth-intensity relation are measured and compared with previous measurements and Monte Carlo expectations. An evaluation of the systematic effects due to uncertainties on environmental and detector parameters is presented.
Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity
2017
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells …
Plexin-B1 activates NF-κB and IL-8 to promote a pro-angiogenic response in endothelial cells.
2011
Background The semaphorins and their receptors, the plexins, are proteins related to c-Met and the scatter factors that have been implicated in an expanding signal transduction network involving co-receptors, RhoA and Ras activation and deactivation, and phosphorylation events. Our previous work has demonstrated that Semaphorin 4D (Sema4D) acts through its receptor, Plexin-B1, on endothelial cells to promote angiogenesis in a RhoA and Akt-dependent manner. Since NF-κB has been linked to promotion of angiogenesis and can be activated by Akt in some contexts, we wanted to examine NF-κB in Sema4D treated cells to determine if there was biological significance for the pro-angiogenic phenotype o…
Marine food web perspective to fisheries-induced evolution
2021
Fisheries exploitation can cause genetic changes in heritable traits of targeted stocks. The direction of selective pressure forced by harvest acts typically in reverse to natural selection and selects for explicit life-histories, usually for younger and smaller spawners with deprived spawning potential. While the consequences that such selection might have on the populational dynamics of a single species are well emphasised, we are just beginning to perceive the variety and severity of its propagating effects within the entire marine food webs and ecosystems. Here, we highlight the potential pathways in which fishing-induced evolution, driven by size-selective fishing, might resonate throu…