Search results for "CASP"
showing 10 items of 470 documents
The Synthetic Cannabinoid WIN 55,212-2 Sensitizes Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-I…
2010
In this article, we demonstrate that the synthetic cannabinoid R-(+)-(2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol[1,2,3-de]-1,4-benzoxazin-6-yl)-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) sensitizes human hepatocellular carcinoma (HCC) cells to apoptosis mediated by tumor necrosis-related apoptosis inducing ligand (TRAIL). The apoptotic mechanism induced by treatment with WIN/TRAIL combination involved the loss of the mitochondrial transmembrane potential and led to the activation of caspases. In HCC cells, WIN treatment induced the up-regulation of TRAIL death receptor DR5, an effect that seemed to be related to the increase in the level of p8 and CHOP, two factors implicat…
Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells
2013
Abstract The importance of dietary polyunsaturated fatty acids (PUFAs) in the reduction of cardiovascular disease has been recognized for many years. Docosahexaenoic acid (22:6n3, DHA) is an n-3 PUFA known to affect numerous biological functions and provide cardioprotection; however, the exact molecular and cellular protective mechanism(s) remain unknown. In contrast, DHA also possesses many anti-tumorgenic properties including suppressing cell growth and inducing apoptosis. In the present study, we investigated the effect of DHA toward H9c2 cells (an immortalized cardiac cell line) and neonatal primary cardiomyocytes (NCM). Cells were treated with 0 μM, 10 μM or 100 μM DHA for upto 48 h. C…
[Diari del Compromís de Casp]
Ms Títol donat pel catalogador Col·lació: Paper, f. i (pergamí actual) + 156 (en blanc els f. 151r-156v) + i (paper) ; foliació moderna a llapis ; signatures de quadern II-VI Composició: Escrit a línia tirada a 27 i 28 línies Escriptura: Gòtica cursiva. Notes marginals d'altra mà (del notari Jaume Desplà) Enquadernació: Pergamí del segle XV, restaurada en 2011 Origen: Escrit a Casp, Saragossa, l'any 1412 després del 28 de juny, data de publicació de la Sentència en la qual es nomena a l'infant de Castella, Ferran, com a rei de la Corona d'Aragó Signatura anterior: Olim 40 Signatura actual: València, Universitat de València. Biblioteca Històrica, BH Ms. 40 Catalogat des del manuscrit origina…
Caspar David Friedrich, di Johannes Grave, München-London-New York, Prestel, 2012, pp. 288, 230 illustrazioni
2014
Cigarette Smoke Extract Induces p38 MAPK-Initiated, Fas-Mediated Eryptosis
2022
Eryptosis is a physiological mechanism for the clearance of senescent or damaged erythrocytes by phagocytes. Excessive eryptosis is stimulated under several pathologies and associated with endothelial injury and thrombosis. Cigarette smoke (CS) is an established risk factor for vascular diseases and cigarette smokers have high-levels of eryptotic erythrocytes. This study, for the first time, investigates the mechanism by which CS damages red blood cells (RBCs). CS extract (CSE) from commercial cigarettes was prepared and standardized for nicotine content. Cytofluorimetric analysis demonstrated that treatment of human RBCs with CSE caused dose-dependent, phosphatidylserine externalization an…
Type V collagen and protein kinase C η down-regulation in 8701-BC breast cancer cells.
2011
We previously reported that ductal infiltrating carcinomas (d.i.c.) of the human breast display profound modifications of the stromal architecture, associated with anomalous collagen composition. Among the major alterations observed in the interstitial collagen, the relative increase of type V collagen content was detected. When type V collagen was used as an ‘‘in vitro’’ substrate for 8701-BC d.i.c. cells, it appeared able to restrain cell growth, inhibit cell motility and invasion ‘‘in vitro’’, and modify the expression levels of genes coding for apoptosis factors, caspases and stress response proteins. In the present paper we demonstrate that type V collagen induces the down-regulation o…
Caspase-9 and beta-endorphin expression in human dental pupl subjected to orthodontic traction
2010
Decisio sacri Supremi Regii Aragonum Consilii in causa nobilitatis, in qua late tractatur de omnibus generibus nobilitatis Regnorum Aragoniae, Valent…
1628
Les 38 f. numerades corresponen a un pleit de la noblesa, interposat per Jeronimo i Marco Antonio de Caspe A les primeres 4 f., que corresponen a les Decisiones, text a dues col. Sign.: œ4, A-I4, K2 Esc. real grav. a la port.
Palermo nel riflesso di Caspe. Tra barricate e dispersione, una città in guerra
2013
I due anni di interregno seguiti alla morte di Martino il Vecchio (1410-1412) erano caratterizzati da un clima di incertezza e intolleranza, lotta per l'indipendenza e scontro tra fazioni. La comunicazione si propone di fare luce sugli anni confusi e difficili, all'insegna di uno stato permanente di guerriglia, vissuti a Palermo in corrispondenza degli avvenimenti che hanno come esito il compromesso di Caspe, attraverso l'esame di documenti, in parte inediti, dell'Archivio Comunale di Palermo.
Abstract 4219: Lysosomal membrane permeabilization, a novel anticancer mechanism induced by pterostilbene
2011
Abstract Pterostilbene (Pter) (3,5-dimethoxy-4′-hydroxystilbene), a natural dimethylated analog of resveratrol, is a phytoalexin abundant in plants and fruits with a number of potential benefits for human health. Darakchasava, an Indian herbal preparation of Vitis Vinifera, contains Pter and is prescribed as a cardiotonic in ayurvedic and traditional medicine. Furthermore, some observations indicate that Pter can be beneficial in the prevention and treatment of different diseases such as diabetes, dyslipidemia, or cancer. Pter shows higher bioavailability than resveratrol. The substitution of two OH groups (positions 3 and 5) by methyl groups increases the stabilityof the molecule and its r…