Search results for "CASS"
showing 10 items of 433 documents
Data from: Plant – herbivorous beetle networks: molecular characterization of trophic ecology within a threatened steppic environment
2015
DNA barcoding facilitates many evolutionary and ecological studies, including the examination of the dietary diversity of herbivores. In this study, we present a survey of ecological associations between herbivorous beetles and host plants from seriously threatened European steppic grasslands. We determined host plants for the majority (65%) of steppic leaf beetles (55 species) and weevils (59) known from central Europe using two barcodes (trnL and rbcL) and two sequencing strategies (Sanger for mono/oligophagous species and Illumina for polyphagous taxa). To better understand the ecological associations between steppic beetles and their host plants, we tested the hypothesis that leaf beetl…
Ancora sulla tutela dei creditori personali del legittimario leso o pretermesso
2020
SOMMARIO: 1. Premessa. – 2. La sentenza della Corte di Cassazione 20 giugno 2019, n. 16623. – 3. La dottrina più recente. – 4. Conclusioni e proposte de iure condendo.
Zvaigžņotā Debess: 2018, Pavasaris (239)
2018
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. Some Considerations about Communication with Extraterrestrial Civilizations (abridged) ; I.Rabinovičs. Does the Moon Affect Living Nature? (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. Brown Dwarfs ; DISCOVERIES: I.Pundure. Odd Movements of Star Reveal Lonely Black Hole in Globular Star Cluster ; I.Pundure. Gaia Enables Viewing Evolution of Orion Constellation over Coming 450 000 Years ; J.Kuzmanis. A Guest from Another Stars ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. To Catch the Galactic Visitor `Oumuamua ; J.Jaunbergs. Invisible Connections of Dione ; LATVIAN SCIENTISTS: The List of Popular Science Papers (1958-2016) by P…
El Guernica. Estudio iconográfico. Jesús María González de Zárate
2014
Recension critica del libro de Jesua Maria Gonzalez de Zarate: El Guernica. Estudio iconografico, Ayuntamiento de Gernika-Lumo, Fundartes, 2013, 93 pp.
Pharmacogenetic Study of ABCB1 and CYP3A5 Genes During the First Year Following Heart Transplantation Regarding Tacrolimus or Cyclosporine Levels
2011
Pharmacogenetics explains part of the interindividual variability in drug responses. Many published works about the effects of single nucleotide polymorphisms (SNPs) on immunosuppressive drug blood levels present contradictory results. We evaluated the SNPs in ABCB1 (glycoprotein P) and CYP3A5 (metabolic enzyme) genes, seeking correlate them with tacrolimus or cyclosporine levels during the first year after heart transplantation. One blood sample was obtained from each of 41 patients: 26 treated with cyclosporine and 15 with tacrolimus. We characterize the SNPs rs1045642, 1128503, 2032582, 2235013, 2235033, 2229109, 3213619, 9282564 in ABCB1 and rs10264272, 776746 in CYP3A5 genes using the …
The ABCB4 p.T175A variant as potential modulator of hepatic fibrosis in patients with chronic liver diseases: Looking beyond the cholestatic realm
2017
TGF-β2 silencing to target biliary-derived liver diseases
2020
ObjectiveTGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases.DesignAs we also found upregulated TGFB2 in liver tissue of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), we now fathomed the positive prospects of targeting TGF-β2 in early stage biliary liver disease using the MDR2-KO mice. Specifically, the influence of TgfB2 silencing on the fibrotic and inflammatory niche was analysed on m…
The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor
2019
Rho kinase activity in hepatic stellate cells (HSCs) is associated with activation, transformation and contraction of these cells, leading to extracellular matrix production and portal hypertension in liver cirrhosis. Inhibition of rho kinase activity can reduce these activities, but may also lead to side effects, for instance systemic hypotension. This can be circumvented by liver-specific delivery of a rho kinase inhibitor to effector cells. Therefore, we targeted the rho kinase inhibitor Y27632 to the key pathogenic cells in liver fibrosis, i.e. myofibroblasts including activated HSCs that highly express the PDGF beta-receptor, using the drug carrier pPB-MSA. This carrier consists of mou…
La nomina di Lodovico Mortara a primo presidente della Corte di Cassazione romana
2019
L’autore, prendendo spunto da un recente libro di Massimiliano Boni e da un articolo pubblicato sul Giornale d’Italia del 30 aprile 1915, ricostruisce la vicenda della tormentata “corsa” di Lodovico Mortara per la presidenza alla Cassazione romana. Ricostruisce anche taluni aspetti della personalità di Mor- tara e degli altri magistrati coinvolti, prendendo in esame le diverse ipotesi circa la possibile paternità dell’articolo sopra menzionato. The author, taking the cue from a recent book by Massimiliano Boni and from an article published in the Giornale d’Italia (April, 30th, 1915), recon- structs the story of the tormented “race” of Lodovico Mortara for the presi- dency of the Roman Cass…
Multixenobiotic resistance efflux activity in Daphnia magna and Lumbriculus variegatus
2014
Multixenobiotic resistance is a phenomenon in which ATP-binding cassette (ABC) family proteins transfer harmful compounds out of cells. Daphnia magna and Lumbriculus variegatus are model species in aquatic ecotoxicology, but the presence and activity of ABC proteins have not been well described in these species. The aim of this work was to study the presence, activity, and inhibition of ABC transport proteins in D. magna and L. variegatus. The presence of abcb1 and abcc transcripts in 8-9-day-old D. magna was investigated by qRT-PCR. The activity of MXR in D. magna and L. variegatus was explored by influx of the fluorescent ABC protein substrates rhodamine B and calcein-AM, with and without…