Search results for "CASS"

Liver and Statins: A Critical Appraisal of the Evidence.

2019

Adverse drug reactions (ADRs) represent an important cause of morbidity and mortality worldwide. Statins are a class of drugs whose main adverse effects are drug-induced liver injury (DILI) and myopathy. Some of these may be predictable, due to their pharmacokinetic and pharmacodynamic properties, while others, unfortunately, are idiosyncratic. Genetic factors may also influence patient susceptibility to DILI and myopathy in the case of statins. This review will first discuss the role of statins in cardiovascular disease treatment and prevention and the underlying mechanisms of action. Furthermore, to explore the susceptibility of statin-induced adverse events such as myopathy and hepatoto…

Bonifici, incassi e carte di pagamento nella Sepa

2011

Laboratori giurisprudenziali di legittimità, flussi nomofilattici e “isole nella corrente”: il coagulo di una nuova sintassi nei rapporti tra Sezioni…

2018

Il contributo esplora la cospicua modifica della sintassi dei rapporti tra sezioni semplici e sezioni unite della Corte di Cassazione plasmata dal “nuovo” art. 618 c.p.p., novellato dalla riforma del 2017: nel telaio di una riorientata funzione nomofilattica del giudice di legittimità, il nuovo volto del sistema, che irradia i suoi effetti ben oltre il perimetro dell’impugnazione di ultima istanza, non manca di porre interrogativi, il cui spessore teorico si accompagna all’analisi degli impatti sul piano della prassi operativa.

The fully developed remnant of a neutrino-driven supernova: Evolution of ejecta structure and asymmetries in SNR Cassiopeia A

2020

Abridged. We aim at exploring to which extent the remnant keeps memory of the asymmetries that develop stochastically in the neutrino-heating layer due to hydrodynamic instabilities (e.g., convective overturn and the standing accretion shock instability) during the first second after core bounce. We coupled a 3D HD model of a neutrino-driven SN explosion with 3D MHD/HD simulations of the remnant formation. The simulations cover 2000 years of expansion and include all physical processes relevant to describe the complexities in the SN evolution and the subsequent interaction of the stellar debris with the wind of the progenitor star. The interaction of large-scale asymmetries left from the ea…

MODELING SNR CASSIOPEIA A from the SUPERNOVA EXPLOSION to ITS CURRENT AGE: The ROLE of POST-EXPLOSION ANISOTROPIES of EJECTA

2016

The remnants of core-collapse supernovae (SNe) have complex morphologies that may reflect asymmetries and structures developed during the progenitor SN explosion. Here we investigate how the morphology of the SNR Cassiopeia A (Cas A) reflects the characteristics of the progenitor SN with the aim to derive the energies and masses of the post-explosion anisotropies responsible for the observed spatial distribution of Fe and Si/S. We model the evolution of Cas A from the immediate aftermath of the progenitor SN to the three-dimensional interaction of the remnant with the surrounding medium. The post-explosion structure of the ejecta is described by small-scale clumping of material and larger-s…

La visita dei Cassinesi di Sicilia nel 1799: la stagione degli equivoci

2011

Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.

2000

The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …

Design of carborane molecular architectures with electronic structure computations: From endohedral and polyradical systems to multidimensional netwo…

2009

11 pags, 6 figs. -- 19th International Conference on Physical Organic Chemistry (ICPOC-19) 13–18 July 2008, Santiago de Compostela, Spain

ABC A-subclass proteins: Gatekeepers of cellular phospho- and sphingolipid transport

2007

During the past years, available evidence suggests that members of a novel family of structurally highly related multispan proteins, designated ABC A-subclass transporters, exert critical functions in the control of cellular lipid transport processes. Loss-of-function scenarios, thus far, have revealed pivotal roles of individual ABC A-transporters in specialized lipid secretory pathways of the cell including HDL biogenesis (ABCA1), lung surfactant production (ABCA3), retinal integrity (ABCA4/ABCR) and skin lipid barrier formation (ABCA12). Although the specific transporter activities of many members of this novel protein family have not yet been established in detail, available evidence in…

Zvaigžņotā Debess: 2017/18, Ziema (238)

2017

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: I.Vilka. Starry Sky and Birds’ Journeys (abridged) ; N.Cimahoviča. Spirals of Saturn’s Rings (abridged) ; I.Šmelds. V Readings of Friedrich Zander ; DEVELOPMENTS in SCIENCE: K.Schwartz. Most Distant Galaxy Clusters and 3D Structure of the Universe ; DISCOVERIES: M.Gills. The Day when Multi-Messenger Astronomy Was Announced ; I.Pundure. ESO Telescopes and Hubble Observe the Source of Gravitational Waves for the First Time ; I.Eglītis. Asteroid “Balklavs” ; SPACE RESEARCH and EXPLORATION: R.Misa. Mission of Cassini – Discoveries to the Very End ; J.Jaunbergs. The Icy World Tethys ; OBSERVATORIES and INSTRUMENTS: M.Gills. The Giant Radio Telescope…