Search results for "CB"
showing 10 items of 647 documents
Rol del complejo RUNX1-CBF-β/HIPK2/p300/p53 en la evolución leucémica de las neoplasias mieloproliferativas crónicas
2019
Las neoplasias mieloproliferativas crónicas (NMPs) son procesos cancerígenos en los que se produce una expansión clonal de una o varias poblaciones de progenitores hematopoyéticos de estirpe mieloide. En las fases iniciales de la enfermedad, éstos presentan una adecuada diferenciación celular, lo que conlleva una descompensación final de los diferentes tipos celulares en médula ósea y sangre periférica y la consiguiente aparición de una serie de síntomas asociados que pueden llegar a producir importantes citopenias o complicaciones vasculares. A pesar de que las NMPs pueden mantenerse relativamente controladas en su fase crónica mediante un tratamiento adecuado, éstas patologías tienen una …
Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination
2019
See Karakaya and Wirth (doi:10.1093/brain/awz273) for a scientific commentary on this article. Neurofascin (NFASC) isoforms are immunoglobulin cell adhesion molecules involved in node of Ranvier assembly. Efthymiou et al. identify biallelic NFASC variants in ten unrelated patients with a neurodevelopmental disorder characterized by variable degrees of central and peripheral involvement. Abnormal expression of Nfasc155 is accompanied by severe loss of myelinated fibres.
Study of Bs->PhiGamma decays at LHCb
2021
This thesis describes two different analyses performed at LHCb using the B0s→φγ and B0→K∗0γ decay channels. First, the measurement of the ratio of branching fractions B(B0→K∗0γ)/B(B0s→φγ) is presented, giving the most precise value for B(B0s→φγ) to date. Secondly, the CP-violating observables S and C, as well as the mixing-induced A∆ parameter are measured through a time-dependent analysis of the B0s→φγ decay channel, this being the first time the S and C observables are probed in the Bs system. These studies are performed using data collected in 2011 and 2012 by the LHCb experiment at CERN, corresponding to an integrated luminosity of 3.0 fb−1 of pp collisions at a center-of-mass energy of…
First observation of a baryonic Bc+ decay
2014
A baryonic decay of the $B_c^+$ meson, $B_c^+\to J/\psi p\overline{p}\pi^+$, is observed for the first time, with a significance of $7.3$ standard deviations, in $pp$ collision data collected with the LHCb detector and corresponding to an integrated luminosity of $3.0$ fb$^{-1}$ taken at center-of-mass energies of $7$ and $8$ $\mathrm{TeV}$. With the $B_c^+\to J/\psi \pi^+$ decay as normalization channel, the ratio of branching fractions is measured to be \begin{equation*} \frac{\mathcal{B}(B_c^+\to J/\psi p\overline{p}\pi^+)}{\mathcal{B}(B_c^+\to J/\psi \pi^+)} = 0.143^{\,+\,0.039}_{\,-\,0.034}\,(\mathrm{stat})\pm0.013\,(\mathrm{syst}). \end{equation*} The mass of the $B_c^+$ meson is dete…
Juvenile ossifying fibroma of the maxillofacial region: analysis of clinico-pathological features and management
2021
Background The diagnosis and management of juvenile ossifying fibroma (JOF) remains a highly debated topic with paucity of studies with long-term follow-up, hence the aim of this study was to report on the clinico-pathological features and management of these neoplasms. Material and Methods A retrospective analysis was performed on all histopathologically confirmed JOF presenting at two tertiary hospitals in Cape Town, South Africa over a period of 39 years. Clinical, demographic, histopathological and radiological features were analyzed. Surgical methods were documented and a minimum post-operative follow-up of 12 months was a prerequisite. Results Seventeen patients met the inclusion crit…
T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells
1980
Fully allogeneic, chimeric mice were established by adult thymectomy of (A × B) F1animals, grafting parental A-type thymus under the kidney capsula, followed by lethal (900 rd) irradiation and reconstitution with B parental-type bone marrow cells treated with xenogeneic anti-T cell antiserum plus complement. Following in vivo sensitization with inactivated Sendai virus (SV) suspensions, no virus-specific T cells could be detected within the spleen cells of the mice. Upon stimulation with third-party allogeneic cells in a primary mixed lymphocyte culture, spleen cells of all animals generated alloreactive cytotoxic T lymphocytes (CTL). More interestingly, upon secondary in vitro stimulation …
Dokumentārās operācijas Latvijas bankās
2021
Autore darbā analizēja Latvijas bankās pieejamos Tirdzniecības finansēšanas produktus – dokumentārās operācijas. Šo banku produktu darbība ir vērsta uz starptautisko preču tirdzniecību. Maģistra darbā autore izmantoja zinātniskās literatūras, Starptautiskās Tirdzniecības palātas publikāciju apkopojumus par šo produktu darbību. Tirdzniecības finansēšana ir tieši saistīta ar efektivitāti kā valsts ekonomikas virzītājspēks, izaugsmē un starptautiskā attīstībā – iespējams, pat stabilitātē un drošībā starptautiskajos darījumos. Pētījumā tiek analizēti šo produktu pieprasījuma dinamika Latvijas bankās, un saistītās problēmas darījumu izpildē, kuras novērtēja Latvijas uzņēmumi un šīs nozares ekspe…
Radzenes biomehānisko rādītāju izmaiņas, izmantojot eksimera lāzeru MEL-90
2017
Ievads: Refraktīvā ķirurģija ir vistraujāk progresējusī oftalmoloģijas joma pēdējo 20 gadu laikā. Neskatoties uz augsto panākumu līmeni, atsevišķos gadījumos tiek konstatēta radzenes ektāzija pēc veiktās operācijas. Ir nepieciešams identificēt ektāzijas attīstības riska faktorus un diagnosticēt ektāziju pirms vizuālām izmaiņām radzenē, lai tiktu uzlabota refraktīvās ķirurģijas kandidātu atlase un, lai ektāziju būtu iespējams efektīvi ārstēt. Pētījuma mērķis: Izvērtēt radzenes biomehānisko rādītāju izmaiņas pēc operācijas, izmantojot eksimera lāzeri MEL-90, un identificēt faktorus, kas varētu veicināt radzenes ektāzijas attīstību. Metodes un materiāli: Pētījumā tika iekļauti pacienti no “Dr.…
Spinal Endocannabinoids and CB 1 Receptors Mediate C-Fiber–Induced Heterosynaptic Pain Sensitization
2009
Plastic Pain Perception Drugs and endocannabinoids acting on cannabinoid (CB) receptors have potential in the treatment of certain types of pain. In the spinal cord they are believed to suppress nociception, the perception of pain and noxious stimuli. Pernia-Andrade et al. (p. 760 ) now find that endocannabinoids, which are released in spinal cord by noxious stimulation, may promote rather than inhibit nociception by acting on CB1 receptors. Endocannabinoids not only depress transmission at excitatory synapses in the spinal cord, but also block the release of inhibitory neurotransmitters, thereby facilitating nociception.
Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi
2020
Iron is an essential micronutrient for most living beings since it participates as a redox active cofactor in many biological processes including cellular respiration, lipid biosynthesis, DNA replication and repair, and ribosome biogenesis and recycling. However, when present in excess, iron can participate in Fenton reactions and generate reactive oxygen species that damage cells at the level of proteins, lipids and nucleic acids. Organisms have developed different molecular strategies to protect themselves against the harmful effects of high concentrations of iron. In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/V…