Search results for "CB"

How many sites of action for endocannabinoids to control energy metabolism?

2006

The promising results obtained by clinical trials using Rimonabant to tackle visceral obesity and related disorders recently promoted a remarkable impulse to carry out detailed investigations into the mechanisms of action of endocannabinoids in regulating food intake and energy metabolism. The endocannabinoid system has been known for many years to play an important role in the modulation of the neuronal pathways mediating the rewarding properties of food. However, in the last few years, with the advanced understanding of the crucial role of the hypothalamic neuronal network in the regulation of appetite, several studies have also directed attention to the orexigenic role of the endocannabi…

El desarrollo de un programa de evaluación online para la preparación de la versión informatizada del First Certificate in English

2012

Las exigencias actuales de la sociedad global de la comunicación han llevado a un gran número de exámenes oficiales de idiomas a adoptar el formato informatizado e incluso online, como ocurre con Cambridge First Certificate in English (FCE). El surgimiento de su versión informatizada hace que aumente la demanda de materiales preparatorios y de evaluación de calidad que tengan en cuenta las características del nuevo formato de examen, planteando ejercicios en concordancia. En este contexto se ha desarrollado el programa preparatorio y de evaluación InGenio FCE Online Tester, en el seno del grupo de investigación CAMILLE, del Departamento de Lingüística Aplicada de la Universitat Politècnica …

Absence of long-term effects of reproduction on longevity in the mouse model.

2014

Background Most human demographic data, particularly those on natural fertility populations, find no relationship or even a positive association between fertility and longevity. The present study aims to ascertain whether there is a trade-off between fertility and longevity in the mouse model. Methods The study was focused on the first litter produced by 10- to 14-wk-old hybrid (C57BL/6JIco female X CBA/JIco male) mice. A single female/male per litter was individually housed with a male/female at the age of 25 and 52 wk, respectively, until the end of reproductive life in females or natural death in males under controlled housing conditions. Post-reproductive females and virgin mice were re…

The ABCB4 p.T175A variant as potential modulator of hepatic fibrosis in patients with chronic liver diseases: Looking beyond the cholestatic realm

2017

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

2015

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10−8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.

Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus

2015

The endocannabinoid system negatively regulates the release of various neurotransmitters in an activity-dependent manner, thereby influencing the excitability of neuronal circuits. In the hippocampus, cannabinoid type 1 (CB1) receptor is present on both GABAergic and glutamatergic axon terminals. CB1 receptor-deficient mice were previously shown to have increased hippocampal long-term potentiation (LTP). In this study, we have investigated the consequences of cell-type-specific deletion of the CB1 receptor on the induction of hippocampal LTP and on CA1 pyramidal cell morphology. Deletion of CB1 receptor in GABAergic neurons in GABA-CB1-KO mice leads to a significantly decreased hippocampal …

Predicting the bioaccumulation of polyaromatic hydrocarbons and polychlorinated biphenyls in benthic animals in sediments

2016

There were two main objectives in this study. The first was to compare the accuracy of different prediction methods for the chemical concentrations of polyaromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in the organism, based on the measured chemical concentrations existing in sediment dry matter or pore water. The predicted tissue concentrations were compared to the measured ones after 28-day laboratory test using oligochaeta worms (Lumbriculus variegatus). The second objective was to compare the bioaccumulation of PAHs and PCBs in the laboratory test with the in situ bioaccumulation of these compounds. Using the traditional organic carbon-water partitioning model, tissue…

Effects of activated carbon ageing in three PCB contaminated sediments: Sorption efficiency and secondary effects on Lumbriculus variegatus.

2015

The sorption efficiency and possible secondary effects of activated carbon (AC) (o 63-200 μm) was studied with Lumbriculus variegatus in three PCB contaminated sediments applying long AC-sediment contact time (3 years). AC amendment efficiently reduced PCB bioavailability as determined with both, L. variegatus bioaccumulation test and passive samplers. However, dose related secondary effects of AC on egestion rate and biomass were observed (applied doses 0.25% and 2.5% sediment dry weight). The sorption capacity and secondary effects remained similar when the experiments were repeated after three years of AC-sediment contact time. Further, transmission electron microscopy (TEM) samples reve…

Wilhelm Pantenius, Jelgawas latweeschu draudzes rihta mahzitajs: us Jelgawas pilsehta un lauku draudses luhgschanu [Vilhelms Panteniuss, Jelgavas lat…

1850

Kredītiestāžu uzraudzības kompetenču sadale vienotā uzraudzības mehānisma ietvaros

2019

Vienotais uzraudzības mehānisma izveidošana ir unikāla Eiropas Savienības konstitucionālajā un administratīvajā sistēmā. Tā ir finanšu uzraudzības sistēma, ko veido ECB un nacionālās kompetentās iestādes. Tas, ka vienotā uzraudzības mehānisma pamatā ir dažādi autonomi elementi, kas atrodas gan nacionālajā, gan Eiropas Savienības līmenī, rada plašas sekas no juridiskās zinātnes viedokļa. Vienotā uzraudzības mehānisma īpašā struktūra rada jautājumus par mijiedarbību starp dažādajiem administratīvajiem līmeņiem un veidiem, kā dažādu līmeņu dalībnieki sadarbojas, lai īstenotu kopīgus uzdevumus un politiskos mērķus. Šī iemesla dēļ ir aktualizējies jautājums par kompetenču sadali starp ECB un nac…