Search results for "CBA"
showing 10 items of 130 documents
Reaction norms of host immunity, host fitness and parasite performance in a mouse - intestinal nematode interaction.
2016
8 pages; International audience; The outcome of the encounter between a host and a parasite depends on the synergistic effects of the genetics of the two partners and the environment (sensulato) where the interaction takes place. Reaction norms can depict how host and parasite traits vary across environmental ranges for different genotypes. Here, we performed a large scale experiment where three strains of laboratory mice (SJL, BALB/c and CBA) were infected with four doses of the intestinal nematode Heligmosomoides polygyrus. An increasing infective dose can be considered as a proxy for the environment-dependent risk incontracting the infection. We looked at the fitness traits of hosts and …
Persistent immune stimulation exacerbates genetically driven myeloproliferative disorders via stromal remodeling
2017
Abstract Systemic immune stimulation has been associated with increased risk of myeloid malignancies, but the pathogenic link is unknown. We demonstrate in animal models that experimental systemic immune activation alters the bone marrow stromal microenvironment, disarranging extracellular matrix (ECM) microarchitecture, with downregulation of secreted protein acidic and rich in cysteine (SPARC) and collagen-I and induction of complement activation. These changes were accompanied by a decrease in Treg frequency and by an increase in activated effector T cells. Under these conditions, hematopoietic precursors harboring nucleophosmin-1 (NPM1) mutation generated myeloid cells unfit for normal …
Early life infection and host senescence
2018
IF 3.224 (2017); International audience; Advanced age is often associated with a chronic inflammatory status and inflammatory diseases. It has been suggested that exposure to infectious agents that stimulate the inflammatory response at early ages might have carry over effects in terms of accelerated senescence and increased mortality at late ages. However, not all pathogens and parasites have pro-inflammatory effects. In particular, parasitic nematodes have been shown to dampen the inflammatory response and to prevent or alleviate the symptoms of inflammatory diseases. We, therefore, tentatively predicted that early infection with a parasite that has anti-inflammatory properties might post…
"Table 3" of "Charm-quark fragmentation fractions and production cross section at midrapidity in pp collisions at the LHC"
2022
Production cross section of charm-anticharm quark pairs per unity of rapidity at midrapidity $\mathrm{d}\sigma^{\mathrm{c\overline{c}}}/\mathrm{d}y|_{|y| < 0.5}$ in pp collisions at $\sqrt{s} = 2.76$, $5.02$, and $7$ TeV.
Latvijas Vēstures Institūta Žurnāls. 2015, Nr. 3 (96)
2015
Valsts kultūrkapitāla fonds
Postnatal development of functional T cell subsets in the mouse: a frequency analysis of mitogen reactive precursors of proliferating, of cytotoxic a…
1985
In order to study the postnatal development of functional T cell subsets in the mouse, a mitogen-driven limiting dilution culture system was used for a precursor frequency analysis of proliferating, of cytolytic and of IL 2-producing T cells, respectively, present in spleen and thymus of mice from neonatal to adult age. In adult mice, the majority (up to 100%) of splenic T cells was capable to respond to Concanavalin A. In contrast, an up to tenfold lower frequency of mitogen-reactive precursors was found within positively selected Thy-1+ spleen cells of neonatal mice. Within this fraction of Con A reactive neonatal T cells, there was an apparent imbalance in the CTLp/PTLp ratio within the …
Vācbaltiešu nacionālās komitejas ietekme Latvijas politikā 1918.-1920.g.
2018
Bakalaura darbā tiek analizēta vācbaltiešu nacionālās komitejas ietekme Latvijas politikā laika posmā no 1918. – 1920. gadam. Šī pētījuma tēma ir aktuāla, jo tā savā izpētē ir bijusi ļoti politizēta. Vācbaltiešu nacionālā komiteja nebija viennozīmīga, kā arī tā piedzīvoja izmaiņas visā pētījumā aplūkotajā laika posmā un līdz ar to arī tās attiecības ar Latvijas valdību. Galvenais darba mērķis ir noskaidrot vācbaltiešu nacionālās komitejas un Latvijas valdības politisko mijiedarbību un nacionālās komitejas lomu Latvijas politikā 1918. – 1920.gadā. Darba izpildei izvirzītie uzdevumi ir aplūkot latviešu un vācbaltiešu sociāli politiskās domas izveidi un savstarpējo mijiedarbību. Analizēt galve…
Vācu faktors Latvijā (1918.-1939.): politiskie un starpnacionālie aspekti
2002
Advisor: Feldmanis, Inesis
T cell-mediated cytotoxicity: discrimination between antigen recognition, lethal hit and cytolysis phase.
1974
Using a 51Cr release cytotoxicity assay, the cytotoxic effector phase of in vitro activated mouse T lymphocytes (killer cells) against 51Cr-labeled target cells has been investigated. It is shown that within 5–10 minutes of contact between killer cells and target cells, the target cells are already committed to lysis, therefore, antigen recognition and “lethal hit” must have taken place within this period of time. In contrast, target cell lysis (cytolysis phase) requires up to 3–4 h in order to be completed; it occurs independently of killer cells and it is highly temperature dependent. The killer cell-dependent phase (antigen-recognition and “lethal hit”) is dissociated into two consecutiv…
Molecular Basis for the Interaction of the Hepatitis B Virus Core Antigen with the Surface Immunoglobulin Receptor on Naive B Cells
2001
ABSTRACTThe nucleocapsid of the hepatitis B virus (HBV) is composed of 180 to 240 copies of the HBV core (HBc) protein. HBc antigen (HBcAg) capsids are extremely immunogenic and can activate naive B cells by cross-linking their surface receptors. The molecular basis for the interaction between HBcAg and naive B cells is not known. The functionality of this activation was evidenced in that low concentrations of HBcAg, but not the nonparticulate homologue HBV envelope antigen (HBeAg), could prime naive B cells to produce anti-HBc in vitro with splenocytes from HBcAg- and HBeAg-specific T-cell receptor transgenic mice. The frequency of these HBcAg-binding B cells was estimated by both hybridom…