Search results for "CCR"
showing 10 items of 574 documents
Promuovere negli uomini la scelta di prepararsi all’esercizio della professione di maestro di scuola primaria
2022
The sixth principle of the Charte de la Ligue Internationale de l’Education Nouvelle of 1921 emphasizes the concept of coeducation. The definition of this concept provides interesting insights to launch a proactive debate on the need to increase the male presence in primary school teaching staff. First of all, some results of empir- ical research that support the request to increase the number of male teachers in the primary school are displayed. Secondly, the most significant measures adopted by some States to promote the figure of the male primary school teacher are described. Finally, a few proposals are made on what could be done in Italy.
The Sustainability Factor: How Much Do Pension Expenditures Improve in Spain?
2020
The reform of 2013 represented a qualitative leap in the reform of the Spanish pension system. Unlike its predecessors, it introduced two automatic resetting mechanisms similar to those of other European countries. The first is the sustainability factor, scheduled to come into effect in 2019 but delayed until 2023, and its ultimate reversal cannot be ruled out. The objective of this study was to quantify the savings, or the lowest expenditure, that can be achieved in the Spanish public contributory pension system by applying it. These savings are measured in terms of cash&mdash
Chronic kidney disease and inflammation: Role of +896A/G pro-inflammatory polymorphism of TLR4 gene and Δ32 deletion of CCR5 gene
2009
bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined ef…
On Using Conceptual Modeling for Ontologies
2004
Are database concepts and techniques suitable for ontology design and management? The question has been on the floor for some time already. It gets a new emphasis today, thanks to the focus on ontologies and ontology services due to the spread of web services as a new paradigm for information management. This paper analyzes some of the arguments that are relevant to the debate, in particular the question whether conceptual data models would adequately support the design and use of ontologies. It concludes suggesting a hybrid approach, combining databases and logic-based services.
Unveiling the nature of six HMXBs through IR spectroscopy
2008
The International Gamma-Ray Astrophyiscs Laboratory (INTEGRAL) is discovering a large number of new hard X-ray sources, many of them being HMXBs. The identification and spectral characterization of their optical/infrared counterparts is a necessary step to undertake detailed study of these systems. In particular, the determination of the spectral type is crucial in the case of the new class of Supergiant Fast X-ray Transients (SFXTs), which show X-ray properties common to other objects. We used the ESO/NTT SofI spectrograph to observe proposed IR counterparts to HMXBs, obtaining Ks medium resolution spectra (R = 1320) with a S/N >= 100. We classified them through comparison with publishe…
Context Standardisation for Learning, Education and Training
2008
This paper presents a new specification to describe the context of learning environments. It provides suggestions how this specification should be discussed and further developed using the concept of social standardisation.
La interpretación judicial en España en un momento de cambio.
2015
The publication in the European Union of Directive 2010/64/EU of the European Parliament and of the Council of 20 October 2010 on the right to interpretation and translation in criminal proceedings has been a turning point in a great number of aspects related to court and police interpretation. The main objective of the Directive is to ensure quality legal interpretation throughout the process, as part of the right to defense and to a fair trial. Spain, as a Member State of the EU, has the obligation to transpose this European Directive into its domestic law. Therefore, this is a historic moment in which two main factors converge: the need to change the legislation to bring it in line with …
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
2015
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10−8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
First M87 Event Horizon Telescope Results. V. Physical Origin of the Asymmetric Ring
2019
The Event Horizon Telescope (EHT) has mapped the central compact radio source of the elliptical galaxy M87 at 1.3 mm with unprecedented angular resolution. Here we consider the physical implications of the asymmetric ring seen in the 2017 EHT data. To this end, we construct a large library of models based on general relativistic magnetohydrodynamic (GRMHD) simulations and synthetic images produced by general relativistic ray tracing. We compare the observed visibilities with this library and confirm that the asymmetric ring is consistent with earlier predictions of strong gravitational lensing of synchrotron emission from a hot plasma orbiting near the black hole event horizon. The ring rad…
Accretion disk coronae of intermediate polar cataclysmic variables
2017
Context. Intermediate polar cataclysmic variables (IPCV) contain a magnetic, rotating white dwarf surrounded by a magnetically truncated accretion disk. To explain their strong flickering X-ray emission, accretion has been successfully taken into account. Nevertheless, observations suggest that accretion phenomena might not be the only process behind it. An intense flaring activity occurring on the surface of the disk may generate a corona, contribute to the thermal X-ray emission, and influence the system stability. Aims. Our purposes are: investigating the formation of an extended corona above the accretion disk, due to an intense flaring activity occurring on the disk surface; studying t…