Search results for "CCR"
showing 10 items of 574 documents
Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth.
2018
Background Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in SCC of tongue and floor of the mouth. Material and Methods A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile. Associations between vari…
Mapping accretion variability in NGC 2264
2014
Our study aims at characterizing the accretion properties of several hundred members of the star-forming region NGC 2264 (3Myr). We performed a deep u,g,r,i mapping of the cluster with CFHT/MegaCam, and monitored the simultaneous u+r variability of its members over a baseline of two weeks. Stellar parameters are determined homogeneously for about 750 monitored young objects, 40% of which are accreting T Tauri stars. Accretion properties and accretion variability are investigated and characterized from UV excess measurements. Non-accreting members of the cluster define the reference UV emission level over which flux excess is detected and measured. Cone search capability for table J/A+A/570/…
How they walk the talk : Responsible management education in Finnish business schools
2022
Responsible management education (RME) has become a common initiative in the educational discourse of business schools worldwide. However, little is known about how (non-)engagement with RME in the past influenced the way RME is organised today. We examine this in one of the pioneering countries of RME, Finland, using extensive qualitative research materials. Our results suggest that RME has been embedded with authenticity-driven change (local context and research) since the 1990s. In the late 2000s after the legal educational reforms implemented in Finland, the prestige-driven change (accreditations) began to shape the embedding of RME. In the 2020s, both the authenticity- and prestige-dri…
Busyness of audit committee directors and quality of financial information in India
2016
The audit committees, as a part of the internal corporate governance mechanisms, play an important role to enhance the financial reporting quality. The busyness of audit committee members of a firm in boards and committees of other firms can affect its independent functioning, ceteris paribus. The current study examines, first, the association between multiple directorships of audit committee members and quality of financial reporting in India, second, whether endogenously determined busyness limits of busyness of the audit committee members provide better insights than those exogenously mandated by regulators. The study finds that endogenously determined busyness limits of sub-samples and …
Shaking the Status Quo: Business Accreditation and Positional Competition
2018
Modern business schools exist in a complex world of rankings, ratings, and credentials. Some argue that in increasingly competitive global higher education markets, signaling status and quality has actually become more important than having them (Gioia & Corley, 2002; Trank & Rynes, 2003). For many contemporary business schools, international accreditations have become key means and first steps in pursuing legitimacy and global status. In this essay, we elaborate in detail on a business school’s international accreditation process, including its motivations and outcomes. We conclude that while accreditation processes are, at best, fruitful quality improvement exercises, the inherent motivat…
External investigations and disciplinary sanctions against auditors: the impact on audit quality
2015
In this paper, we provide empirical evidence for the impact of disciplinary sanctions imposed on Spanish auditing firms and their engagement partners. The disciplinary sanctions resulted from external investigations, which revealed misapplications of auditing standards. In particular, we evaluate (a) the efficacy of the external supervisory board in identifying low-quality auditors and (b) the effectiveness of the disciplinary system in improving the quality of subsequent statutory audits performed by the sanctioned auditors. We employ two earnings management indicators as proxies for audit quality: loss avoidance through extraordinary items and abnormal accruals. And we compare these measu…
Reassessment of continental growth during the accretionary history of the Central Asian Orogenic Belt
2014
We argue that the production of mantle-derived or juvenile continental crust during the accretionary history of the Central Asian Orogenic Belt (CAOB) has been grossly overestimated. This is because previous assessments only considered the Palaeozoic evolution of the belt, whereas its accretionary history already began in the latest Mesoproterozoic. Furthermore, much of the juvenile growth in Central Asia occurred in late Permian and Mesozoic times, after completion of CAOB evolution, and perhaps related to major plume activity. We demonstrate from zircon ages and Nd–Hf isotopic systematics from selected terranes within the CAOB that many Neoproterozoic to Palaeozoic granitoids in the accre…
Structural framework and crustal characteristics of the Sardinia Channel Alpine transect in the central Mediterranean
2000
Abstract The submerged area located between the Sardinia Channel and the western Sicily offshore has been investigated based on deep crustal and conventional seismic lines with the aim of illustrating the relationships between the crust and its overlying crystalline and sedimentary thrust wedge. Analyses of seismic attributes and reflector pattern, supported by dredge hauls, also provided data in areas where stratigraphic and lithologic control is absent. Crustal geometries, tectonic processes and timing of the deformation are discussed here. North of the Elimi chain (central Sardinia Channel) the reflecting body consists of superposed tectonic wedges of crystalline rocks and their Meso-Cen…
Shallow structures at the outer Calabrian accretionary wedge (NW Ionian Sea): new insights from recently migrated reflection data
2010
Terra Nova, 00, 000–000, 2010 Abstract Post-stack time migration of a set of seismic reflection profiles reveals details of the stratigraphic–structural setting of the outermost Calabrian accretionary wedge, in the NW sector of the Ionian Sea, with particular emphasis on the Messinian stratigraphy and the deformation style of the thin frontal portion of this wedge. A structural style and seismic facies analysis, calibrated by refraction data, images a general bipartition of the Messinian evaporite deposits: the `lower subunit', consisting mainly of salt, appears to have undergone ductile-flow deformation, and the `upper subunit', consisting mainly of gypsum and marls, appears to be characte…
3D Architecture and Plio-Quaternary evolution of the Paola Basin: New insights to the Forearc of the Tyrrhenian-Ionian Subduction System
2018
The 3D stratigraphic architecture and the Pliocene to Quaternary evolution of the Paola Basin (offshore western Calabria), a segment in the fore-arc of the Tyrrhenian-Ionian subduction system, are reconstructed by using a grid of unpublished of multi-channels, high-penetration, seismic-reflection profiles acquired in the frame of the project SINBUS, integrated by bathymetric data from EMODnet-Bathymetry portal. The Paola Basin is a NNW-SSE elongated, ~ 60 km long and ~20 km wide, slightly asymmetric syncline, which hosted Plio-Quaternary deposits up to 5.5 km thick in its depocenter. The Plio-Quaternary sequence shows an eastward progradational internal geometry that becomes sub-horizontal …