Search results for "CCT."

Biopolitik am Computerbildschirm, in V. Borsò e M. Cometa (a cura) Die Kunst, das Leben zu Bewirtschaften. Biós zwischen Politik, Öikonomie und Äeste…

2013

Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated…

2023

Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics approach, we investigated the occurrence of conformational changes and differences in physicochemical properties of the CCT5 mutations His147Arg and Leu224Val associated with a sensory and a motor distal neuropathy, respectively. The apical domain of both variants was substantially but differently affected by the mutations, although these were in other domains. The distribution of hydrogen bonds and electrostatic potentials on the surfa…

Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit.

2022

Recognition of diseases associated with mutations of the chaperone system genes, e.g., chaperonopathies, is on the rise. Hereditary and clinical aspects are established, but the impact of the mutation on the chaperone molecule and the mechanisms underpinning the tissue abnormalities are not. Here, histological features of skeletal muscle from a patient with a severe, early onset, distal motor neuropathy, carrying a mutation on the CCT5 subunit (MUT) were examined in comparison with normal muscle (CTR). The MUT muscle was considerably modified; atrophy of fibers and disruption of the tissue architecture were prominent, with many fibers in apoptosis. CCT5 was diversely present in the sarcolem…

GENETIC NEUROCHAPERONOPATHIES ASSOCIATED WITH CCT5 AND HSP60 VARIANTS: ANALYSIS OF THEIR MOLECULAR ANATOMY AND POSSIBLE PATHOGENIC IMPLICATIONS

2022

Technology Comprehension

2018

We account for the first research results from a government initiatedexperiment that scales Making to a national discipline.The Ministry of Education, in Denmark, has introducedTechnology Comprehension as a new discipline for lowersecondary education. Technology Comprehension is first experimentedas an elective subject in 13 schools. The disciplinecombines elements from computing, design, and the societalaspect of technology and, thus, resonates with the existingFabLearn and Making initiatives in Scandinavia. We reportthe identified opportunities and challenges based on interviews,surveys, and a theme discussion with experiencedteachers from the 13 schools. The main takeaways are: First,the…

Eettinen kuluttaminen kulutuskulttuurissa

2016

The aim of this dissertation is to contribute to our knowledge and understanding of the various meanings of ethical consumption constructed in consumer culture, especially from consumers’ viewpoint. This doctoral thesis belongs to the field of cultural and interpretive consumption research (CCT). The research consists of an introductory essay and three articles, of which two are published in academic journals. The introductory essay presents the general research task, conceptual framework, and methodological choices and discussion to conclude the main results of the dissertation. The research included in this dissertation uses qualitative methods and applies discursive content analysis, geo…

Samsung and Volkswagen Crisis Communication in Facebook and Twitter : A Comparative Study

2017

Since September 2015 at least two major crises have emerged where major industrial companies producing consumer products have been involved. In September 2015 diesel cars manufactured by Volkswagen turned out to be equipped with cheating software that caused NO2 and other emission values to be reduced to acceptable levels while tested from the real, unacceptable values in normal use. In August 2016 reports began to appear that the battery of a new smart phone produced by Samsung, Galaxy Note7, could begin to burn, or even explode, while the device was on. In Nov. 2016 also 34 washing machine models were reported to have caused damages due to disintegration. In all cases, the companies have …

Evaluation of IS Curriculum Design : A Pilot Study using the California Critical Thinking Skills Test

2017

Technical development in cardiac CT: current standards and future improvements—a narrative review

2020

Non-invasive depiction of coronary arteries has been a great challenge for imaging specialists since the introduction of computed tomography (CT). Technological development together with improvements in spatial, temporal, and contrast resolution, progressively allowed implementation of the current clinical role of the CT assessment of coronary arteries. Several technological evolutions including hardware and software solutions of CT scanners have been developed to improve spatial and temporal resolution. The main challenges of cardiac computed tomography (CCT) are currently plaque characterization, functional assessment of stenosis and radiation dose reduction. In this review, we will discu…

Clinical indications for cardiac computed tomography. From the Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radio…

2012

"\"La tomografia computerizzata del cuore (CCT) è diventata uno strumento efficace in differenti contesti clinici. Lo sviluppo della tecnologia ha portato ad una progressiva espansione delle indicazioni con una concomitante riduzione della dose di radiazioni necessaria per l’esecuzione dell’indagine. Ancora oggi sono pochi i documenti delle maggiori società scientifiche internazionali che si esprimono sulle effettive modalità di utilizzo e sulle indicazioni cliniche della CCT; in particolare mancano delle linee guida complete. Questo documento rispecchia la visione del gruppo di lavoro della Sezione di Cardio-Radiologia della Società Italiana di Radiologia Medica in merito alle indicazioni …