Search results for "CCT"
showing 10 items of 41 documents
Radiofrequency thermal ablation vs percutaneous ethanol injection for small hcc in cirrhosis:metanalysis of randomized controlled trials
2009
1. Am J Gastroenterol. 2009 Feb;104(2):514-24. Epub 2009 Jan 13. Radiofrequency thermal ablation vs. percutaneous ethanol injection for small hepatocellular carcinoma in cirrhosis: meta-analysis of randomized controlled trials. Orlando A, Leandro G, Olivo M, Andriulli A, Cottone M. Department of Medicine, Pneumology and Nutrition Clinic, V. Cervello Hospital, University of Palermo, Piazza Mameli 1, Palermo, Italy. ambrogiorlando@tiscali.it OBJECTIVES: Radiofrequency thermal ablation (RF) and percutaneous ethanol injection (PEI) have been employed in the treatment of small hepatocellular carcinoma (HCC) as curative treatments. The aim of the study was to review the available evidence compari…
Biopolitik am Computerbildschirm, in V. Borsò e M. Cometa (a cura) Die Kunst, das Leben zu Bewirtschaften. Biós zwischen Politik, Öikonomie und Äeste…
2013
Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated…
2023
Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics approach, we investigated the occurrence of conformational changes and differences in physicochemical properties of the CCT5 mutations His147Arg and Leu224Val associated with a sensory and a motor distal neuropathy, respectively. The apical domain of both variants was substantially but differently affected by the mutations, although these were in other domains. The distribution of hydrogen bonds and electrostatic potentials on the surfa…
Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit.
2022
Recognition of diseases associated with mutations of the chaperone system genes, e.g., chaperonopathies, is on the rise. Hereditary and clinical aspects are established, but the impact of the mutation on the chaperone molecule and the mechanisms underpinning the tissue abnormalities are not. Here, histological features of skeletal muscle from a patient with a severe, early onset, distal motor neuropathy, carrying a mutation on the CCT5 subunit (MUT) were examined in comparison with normal muscle (CTR). The MUT muscle was considerably modified; atrophy of fibers and disruption of the tissue architecture were prominent, with many fibers in apoptosis. CCT5 was diversely present in the sarcolem…
GENETIC NEUROCHAPERONOPATHIES ASSOCIATED WITH CCT5 AND HSP60 VARIANTS: ANALYSIS OF THEIR MOLECULAR ANATOMY AND POSSIBLE PATHOGENIC IMPLICATIONS
2022
Experimental Set up of Advanced Lighting Systems for Load Shifting Strategies
2021
Shiftable and modulable loads are an essential part of smart grids in the effort for improving the efficiency of the power system and providing new ancillary services. Most of the researches considered shiftable loads and the impact on the power grid. Smart lighting systems are able to modulate their consumption while preserving the visual duty, therefore they can take part to this action. In this context, this paper presents an advanced experimental setup implemented in the SolarLab of the University of Palermo, with the aim of studying the impact on the end-user's energy consumption and on the power grid of smart lighting systems. In this light, different control strategies will be consid…
Technology Comprehension
2018
We account for the first research results from a government initiatedexperiment that scales Making to a national discipline.The Ministry of Education, in Denmark, has introducedTechnology Comprehension as a new discipline for lowersecondary education. Technology Comprehension is first experimentedas an elective subject in 13 schools. The disciplinecombines elements from computing, design, and the societalaspect of technology and, thus, resonates with the existingFabLearn and Making initiatives in Scandinavia. We reportthe identified opportunities and challenges based on interviews,surveys, and a theme discussion with experiencedteachers from the 13 schools. The main takeaways are: First,the…
Eettinen kuluttaminen kulutuskulttuurissa
2016
The aim of this dissertation is to contribute to our knowledge and understanding of the various meanings of ethical consumption constructed in consumer culture, especially from consumers’ viewpoint. This doctoral thesis belongs to the field of cultural and interpretive consumption research (CCT). The research consists of an introductory essay and three articles, of which two are published in academic journals. The introductory essay presents the general research task, conceptual framework, and methodological choices and discussion to conclude the main results of the dissertation. The research included in this dissertation uses qualitative methods and applies discursive content analysis, geo…
Samsung and Volkswagen Crisis Communication in Facebook and Twitter : A Comparative Study
2017
Since September 2015 at least two major crises have emerged where major industrial companies producing consumer products have been involved. In September 2015 diesel cars manufactured by Volkswagen turned out to be equipped with cheating software that caused NO2 and other emission values to be reduced to acceptable levels while tested from the real, unacceptable values in normal use. In August 2016 reports began to appear that the battery of a new smart phone produced by Samsung, Galaxy Note7, could begin to burn, or even explode, while the device was on. In Nov. 2016 also 34 washing machine models were reported to have caused damages due to disintegration. In all cases, the companies have …