Search results for "CD"
showing 10 items of 4072 documents
Antimicorbial prophylaxis in patients with immune thrombocytopenia treated with rituximab:a retrospective analysis
2019
Correlation between cell line chemosensitivity and protein expression pattern as new approach for the design of targeted anticancer small molecules
2022
BACKGROUND AND RATIONALE: Over the past few decades, several databases with a significant amount of biological data related to cancer cells and anticancer agents (e.g.: National Cancer Institute database, NCI; Cancer Cell Line Encyclopedia, CCLE; Genomic and Drug Sensitivity in Cancer portal, GDSC) have been developed. The huge amount of heterogeneous biological data extractable from these databanks (among all, drug response and protein expression) provides a real foundation for predictive cancer chemogenomics, which aims to investigate the relationships between genomic traits and the response of cancer cells to drug treatment with the aim to identify novel therapeutic molecules and targets…
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.
2008
Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …
Skolotāju apmierinātība ar darbu
2020
Maģistra darba mērķis ir izpētīt Latvijas pamatizglītībā strādājošo skolotāju apmierinātību ar savu darbu. Teorētiskā daļa sastāv no 2 nodaļām. Pirmajā nodaļā analizēts un aplūkots apmierinātības ar darbu skaidrojums dažādu autoru skatījumā. Otrajā nodaļā tika aplūkota skolotāju apmierinātība ar darbu, izglītības iestādes vadītāja loma tajā, kā arī darba vides ietekmējošie faktori skolotāju apmierinātību ar darbu. Empīriska daļa sastāv no 1 nodaļas ar 5 apakšnodaļām. Visās apakšnodaļās tiek analizēti dati OECD TALIS 2013 un TALIS 2018 pētījumu dati par Latvijas skolotāju apmierinātību ar darbu. Pētīts, kā apmierinātība ar darbu saistīta ar skolotāju vecumu, skolas tipu un skolas atrašanās v…
Studio dell'apoptosi cellulare nella pre-eclampsia mediante valutazione del CD95 linfocitario in pazienti trattate con antitrombina III
2009
L'etimologia della pre-eclampsia rimane ancora oggi sconosciuta ma sappiamo abbastanza sulla sua fisiopatologia, da consentire l'adozione di presidi terapeutici atti ad espletare un controllo sintomatologico della sindrome ma non a curarla. Nel presente lavoro ci siamo posti l'obiettivo di valutare in corso di trattamento con ATIII l'andamento dei valori di CD95 dei linfociti del circolo periferico, in qualità di indicatore dei processi di apoptosi cellulare in una condizione di "Graft versus host disease", quale potrebbe considerarsi la gravidanza complicata da pre-eclampsia.
Identification of genes activated during arbuscular mycorrhiza interactions by suppressive substractive hybridisation and cloning of differential exp…
2000
International audience
Dzīves kvalitāte bērniem ar atopisko dermatītu
2022
Atopiskais dermatīts pieder pie visizplatītākajām ādas slimībām pasaulē. Tā ir hroniska, alerģiska, iekaisuma ādas saslimšana, kas pārsvarā skar bērnus pirmsskolas vecumā. Dzīves kvalitātes rādītājs bērniem ar atopisko dermatītu ir būtisks parametrs, kas palīdz izvērtēt gan terapijas efektivitāti, gan bērna veselības stāvokli. Dzīves kvalitātes kontrole bērniem ar atopisko dermatītu, dot iespēju atrast problēmas, pie kurām tika pievērsta mazāka uzmanība un atrast iespējamos variantus, aprūpes taktikas uzlabošanai. Pētījuma mērķi. Analizēt dzīves kvalitāti bērniem ar atopisko dermatītu dažādās vecuma un dzimumu grupās, kā arī sakarībā ar slimību raksturojošiem faktoriem. Materiāli un metodes…
Espectro clínico y genético de las neuropatías hereditarias motoras distales en la Comunidad Valenciana
2022
Las neuropatías hereditarias motoras distales (NHMd) son enfermedades neuromusculares de origen genético que se caracterizan por una degeneración de la parte motora de los nervios periféricos. Se engloban dentro de un grupo más amplio de neuropatías hereditarias llamadas neuropatías tipo Charcot- Marie-Tooth (CMT). Son enfermedades que afectan a gente joven y producen una discapacidad importante. Actualmente no disponemos de tratamiento que modifique el curso de las NHMd, por lo que los esfuerzos en investigación en este grupo de enfermedades son muy importantes. El diagnóstico y el estudio de la historia natural de las diferentes formas de NHMd es complicado porque son enfermedades poco fr…
Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…
2006
BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…
Search for weakly decaying b -flavored pentaquarks
2018
Investigations of the existence of pentaquark states containing a single $b$ (anti)quark decaying weakly into four specific final states J/$\psi K^+\pi^- p$, J/$\psi K^- \pi^- p$, J/$\psi K^- \pi^+ p$, and $J/\psi \phi (1020) p$ are reported. The data sample corresponds to an integrated luminosity of 3.0/fb in 7 and 8 TeV pp collisions acquired with the LHCb detector. Signals are not observed and upper limits are set on the product of the production cross section times branching fraction with respect to that of the $\Lambda_b$.