Search results for "CD"
showing 10 items of 4072 documents
Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells.
2022
Intercellular communication between cancer cells themselves or with healthy cells in the tumor microenvironment and/or pre-metastatic sites plays an important role in cancer progression and metastasis. In addition to ligand–receptor signaling complexes, extracellular vesicles (EVs) are emerging as novel mediators of intercellular communication both in tissue homeostasis and in diseases such as cancer. EV-mediated transfer of molecular activities impacting morphological features and cell motility from highly metastatic SW620 cells to non-metastatic SW480 cells is a good in vitro example to illustrate the increased malignancy of colorectal cancer leading to its transformation and aggressive b…
Fenomeni di polarizzazione in rivelatori Al/CdTe/Pt per spettroscopia X e gamma
2014
L’uso dei rivelatori a semiconduttore ha avuto, negli anni, un’importanza strategica nella spettroscopia X e gamma (1 keV – 2 MeV), con eccellenti risultati sia in applicazioni mediche che astrofisiche. L’imaging medicale (mammografia, tomografia computerizzata), il monitoraggio ambientale (radiazione di fondo), rivelatori da piano focale per telescopi X in astrofisica e sistemi di fluorescenza a raggi X nei Beni Culturali ne rappresentano alcune importanti applicazioni. I rivelatori a semiconduttore hanno trovato largo impiego grazie alle loro interessanti proprietà soprattutto se confrontate con i sistemi di rivelazione tradizionali (a gas e scintillatori); un migliore rapporto segnale-ru…
Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells
2011
Verbena officinalis L., Verbenaceae, commonly known as vervain, is a plant widely used in medicine. Despite of its widespread use in different traditional practices, the mechanisms of pharmacological actions of the plant and its volatile oil are still unclear. We evaluated the pro-apoptotic activity of V. officinalis essential oil and of its main component, citral, on lymphocytes collected from ten patients with chronic lymphocytic leukaemia (CLL), a disease in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events, by adding to treated mononuclear cells, annexin-V, propidium iodide, and CD19. Apoptosis was also evaluated using anti-active-caspase-3 monocl…
SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B
2014
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously dividing cancer cells might unbalance this ratio and critically affect tumour outgrowth. We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression. SCD5 is down-regulated in advanced melanoma and its restored expression significantly reduced melanoma malignancy, both in vitro and in vivo, through a mechanism governing the secretion of extracellular matrix proteins, such as secreted protein acidic and rich in cysteine (SPAR…
Evaluación de marcadores inmunohistoquímicos de angiogénesis tumoral como factor pronóstico en el adenocarcinoma pulmonar en estadio IA
2019
El cáncer de pulmón (CP) es la neoplasia más frecuentemente diagnosticada y la que más muertes causa en el mundo. A pesar de los avances disponibles en el diagnóstico y el tratamiento aun presenta una tasa de supervivencia entorno al 15%. El objetivo de este trabajo fue investigar y correlacionar factores morfológicos del ADC de pulmón con la expresión de marcadores de angiogénesis tumoral como factor pronóstico, en pacientes resecados y clasificados como T1a-b-cN0M0 patológico, de la 8ª clasificación TNM. Por tanto, se realizó un proyecto de investigación clínica, de naturaleza observacional y analítico, con recogida de datos retrospectivos de los casos a partir de los archivos de historia…
Is CD1a involved in antitumour immune responses during carcinogenesis?
2004
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors
2018
Cyclin-dependent kinase-2 (CDK2) is a member of serine/threonine protein kinases family. It plays an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidences indicate that excessive expression of CDK2 should cause abnormal cell cycle regulation. Therefore, CDK2 has been considered a potential therapeutic target for cancer therapy. In this work, we used a modelling approach that incorporates flexibility based on extensive MD simulations of protein−ligand complexes into structure-based pharmacophore modeling and virtual screening to identify new CDK2 inhibitors. One-hundred and forty-nine CDK2-inhibit…
Design, sinthesis and anticancer properties of new cdks inhibitors
2010
Anterior cervical discectomy and fusion is more effective than cervical arthroplasty in relieving atypical symptoms in patients with cervical spondyl…
2022
Background and purpose Patients with cervical spondylosis often present with concurrent 'atypical symptoms' of unknown etiology that have been associated with cervical spondylotic disease, including dizziness, headache, nausea, tinnitus, blurred vision, palpitations, and memory and gastrointestinal disturbances. Few studies have addressed whether surgical intervention to treat classic symptoms of cervical spondylosis can also effectively alleviate atypical symptoms. Accordingly, the purpose of this study is to compare the ability of cervical arthroplasty (CA) and anterior cervical discectomy and fusion (ACDF) to alleviate atypical symptoms associated with cervical spondylosis. Materials and…
Safety and efficacy of cervical disc arthroplasty in preventing the adjacent segment disease: a meta-analysis of mid- to long-term outcomes in prospe…
2019
Objectives: Cervical disc arthroplasty (CDA) has become an alternative treatment for cervical radiculopathy and myelopathy. This technique preserves appropriate motion at both the index and adjacent disc levels and consequently may prevent adjacent segment degeneration (ASD). The authors performed a meta-analysis to compare the safety and efficacy of CDA to those of the gold standard, anterior cervical discectomy and fusion (ACDF). Both surgical and clinical parameters were employed to verify the hypothesis that CDA can reduce the risk of ASD. Methods: The meta-analysis comprised high-quality randomized controlled trials that compared CDA and ACDF treatments of cervical degenerative disc di…