Search results for "CD"
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CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis
2019
Abstract Background and Aims: In immunosuppressed individuals Aspergillus (A.) fumigatus is a frequent cause of invasive pulmonary aspergillosis (IPA) which is highly associated with relevant morbidity and mortality. Moreover, it often occurs in patients suffering from leukocyte-adhesion deficiency type 1 (LAD1) which is triggered by a functional loss of CD18 in ß2 integrin receptors as these receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit. ß2 integrin receptors are differentially expressed by leukocytes, and are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Here, we asked …
HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy
2019
CD4+ T cells differentiate into various T helper subsets characterized by distinct cytokine secreting profiles that confer them effector functions adapted to a variety of infectious or endogenous threats. Regulatory CD4+ T cells are another specialized subset that plays a fundamental role in the maintenance of immune tolerance to self-antigens. Manipulating effector or regulatory CD4+ T cells responses is a promising immunotherapy strategy for, respectively, chronical viral infections and cancer, or severe autoimmune diseases and transplantation. Adoptive cell therapy (ACT) is an emerging approach that necessitates defining robust and efficient methods for the in vitro expansion of antigen-…
Control of Murine Cytomegalovirus Infection by γδ T Cells
2015
Infections with cytomegalovirus (CMV) can cause severe disease in immunosuppressed patients and infected newborns. Innate as well as cellular and humoral adaptive immune effector functions contribute to the control of CMV in immunocompetent individuals. None of the innate or adaptive immune functions are essential for virus control, however. Expansion of γδ T cells has been observed during human CMV (HCMV) infection in the fetus and in transplant patients with HCMV reactivation but the protective function of γδ T cells under these conditions remains unclear. Here we show for murine CMV (MCMV) infections that mice that lack CD8 and CD4 αβ-T cells as well as B lymphocytes can control a MCMV i…
Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab
2015
International audience; Natalizumab (NTZ), a monoclonal antibody recognizing the alpha4 integrin chain, has been approved for the treatment of active multiple sclerosis, but expose to the onset of a rare side effect, progressive multifocal leukoencephalopathy (PML). Estimating the individual risk of PML in NTZ-treated patients is a major challenge, and therapeutic strategies are mainly guided by the overall PML risk assessed by identified risk factors: JC virus (JCV) seropositivity, treatment duration (with peak incidence after 24 months), and the previous use of immunosuppressive therapies. Given that this stratification does not yet allow a precise individual prediction of PML, other pred…
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined. Viral infections can trigger the release of the alarmin interleukin-33 (IL-33) from non-hematopoietic cells. IL-33 signals through its unique receptor ST2 to promote primary effector expansion and activation of CTLs. Here, we show that the transcription factor STAT4 regulated the expression of ST2 on CTLs in vitro and in vivo in primary infections with lymphocytic choriomeningitis virus (LCMV). In the primary antiviral response, IL-33 enhanced effector differentiation and antiviral cytokine production in a CTL-intrinsic manne…
B lymphocyte intestinal homing in inflammatory bowel disease.
2011
Abstract Background Inflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically natural antibodies but pathologically atypical anti-neutrophil antibodies (xANCAs) are frequently observed in patients with IBD. The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features. Methods The IPCs in small intestinal, colonic and rectal biopsy specimens of patients with IBD were analysed by means of immun…
Blood Transfusion Management for Patients Treated With Anti-CD38 Monoclonal Antibodies
2018
Daratumumab has proven to be highly efficacious for relapsed and refractory multiple myeloma (MM) and has recently been approved in the frontline setting for MM patients ineligible for transplantation. In the future, expanded indications are possible for daratumumab and other anti-CD38 monoclonal antibodies in development. For several years, it has been recognized that these therapies interfere with blood bank testing by binding to CD38 on red blood cells and causing panagglutination on the Indirect Antiglobulin Test. This can lead to redundant testing and significant delays in patient care. Given the anticipated increase in utilization of anti-CD38 monoclonal antibodies, as well as the tra…
La interacción cooperativa: condición social de aprendizaje
2003
No cabe duda de que la naturaleza de la práctica educativa es fundamentalmente social, un proceso en el que las personas discurren e interactúan mutuamente como parte de una red de influencias sociales definidas y deliberadas: «[ ... ] la educación es la revelación de los demás, de la condición humana como concierto de complicidades irremediables» (Savater 2001: 35). Sin embargo, al ser la educación un tipo de interacción social intencional, no se puede dejar de destacar que la forma en que se organiza esta interacción en los procesos sociales con fines formativos, como los que ocurren en la escuela, tenga consecuencias importantes en los resultados del aprendizaje, es decir, en los proceso…
Notes sobre la tradició textual del Llibre dels Àngels de Francesc Eiximenis
2010
L’edició completa de les obres de Francesc Eiximenis és una empresa filològica que presenta dificultats objectives, no només perquè les obres tenen un pes material més que considerable, sinó també per la gran quantitat de testimonis manuscrits i impresos que cal col·lacionar. Amb l’objectiu d’ajudar a superar aquestes dificultats, ja fa alguns anys que l’Institut de Llengua i Cultura Catalanes de la Universitat de Girona ha emprès la publicació de les Obres de Francesc Eiximenis, i avui afortunadament podem afirmar que les obres d’Eiximenis, especialment les inèdites, ja tenen equips de treball que s’ocupen de la preparació de les edicions corresponents. Paral·lelament, i en la mateixa líni…
Hernández, Esther. Lexicografía hispano-amerindia 1550-1800. Catálogo descriptivo de los vocabularios del español y las lenguas indígenas americanas.…
2019
Publicado como el volumen 9 de la colección “Lingüística misionera” de la editorial Iberoamericana, Esther Hernández nos ofrece un completo “catálogo descriptivo de los vocabularios del español y las lenguas indígenas americanas”, tal como reza el subtítulo, que registra las obras lexicográficas correspondientes entre 1550 y 1800. Si bien la etiqueta de “lingüística” puesta a la práctica lexicográfica (y gramaticográfica) de los misioneros en la época colonial es ciertamente polémica —como lo recuerda Wulf Oesterreicher en un artículo póstumo aparecido recientemente—, esta se ha ido convirtiendo en las últimas décadas en un importante objeto de estudio sistemático, lo que se muestra tanto …