Search results for "CD"
showing 10 items of 4072 documents
T cell–mediated response to SARS‐CoV‐2 in liver transplant recipients with prior COVID‐19
2021
Abstract Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2‐specific T‐cell‐mediated immunity (SARS‐CoV‐2‐CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS‐CoV‐2‐CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)‐γ FluoroSpot assay after a median of 103 days from COVID‐19 diagnosis. Serum SARS‐CoV‐2 IgG antibodies were measured by ELISA. A control group of non‐transplant immunocompetent patients were matched (1:1 ratio) by age and time from diagnosis. Post‐transplant SARS‐CoV‐2‐CMI was detected by ICS in 90.3% (28/31) of recipients, with higher proportions for IFN‐γ‐producing CD4+ than …
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
2004
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of the principal enzymes released upon PMN activation is myeloperoxidase (MPO), a heme protein that not only generates cytotoxic oxidants but also impacts deleteriously on nitric oxide-dependent signaling cascades within the vasculature. Because MPO also associates with the membrane of PMN, we evaluated whether MPO could also function as an autocrine modulator of PMN activation. The extent of PMN membrane-associated MPO was elevated in patients with acute inflammatory vascular disease compared with…
Recensione a: Polipticum quod appellatur Perpendiculum
2021
Recensione alla prima vera e propria edizione critica del Polipticum quod appellatur Perpendiculum di Attone di Vercelli, curata da Giacomo Vignodelli e con un saggio di Luigi G.G. Ricci, apparsa a Firenze, presso la SISMEL – Edizioni del Galluzzo, nel 2019, all'interno dell'Edizione Nazionale dei Testi Mediolatini d’Italia. Review of the first real critical edition of the Polipticum quod appellatur Perpendiculum by Attone di Vercelli
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction
2010
Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…
The Subjective Social Value of Education Construct: CrossValidation between School and University Teachers
2016
La Educación posee un valor social evidente que puede presentarse mediante indicadores de evaluación socio-educativos. Si bien la relación entre contexto escolar y rendimiento es evidente en diversos países, esta relación va perdiendo consistencia en los últimos años; ya que aparecen sectores estudiantiles que superan las predicciones académicas esperadas. Para ello, se estudia el Valor Social Subjetivo de la Educación en función de dos grupos docentes –escuela y universidad–. La metodología es complementaria a través de comités de expertos/as y validación cruzada de constructo. Se realizan análisis sobre dos escalas –relevancia y susceptibilidad de cambio– y entre dos muestras diferenciada…
Les moyens rhétoriques dans l'oeuvre de Francis Cabrel
1998
Enhancing the performance of HSDPA communication with multipoint transmission techniques
2015
The evolution of mobile phones, tablets and other mobile communication devices has led to a significant increase in the amount of data delivered over mobile networks. In order to satisfy the climbing data rate demands of customers, existing mobile broadband networks are being expanded with new features that allow ubiquitous and consistent networking experience. This research presents three multipoint transmission techniques for Wideband Code Division Multiple Access (WCDMA) based High-Speed Downlink Packet Access (HSDPA) communication protocol. Multiflow, High-Speed Single-Frequency Network (HS-SFN) and Multipoint-to-Point Single-Frequency Network (M2P-SFN) enable transmission of user-dedicat…
Introduction to next-generation engineering: Being human in the information society
2022
While adopting Information Technology (IT) may have been a goal in itself in the past, during the last decade the emphasis has shifted, and IT has instead become a tool that enables us to realize other needs. This also sets new requirements for IT education: skills in software engineering and computer science alone do not provide students with the professional abilities they will need after graduation. To answer this call, the University of Jyväskylä launched in autumn 2021 a new engineering B.Sc. and M.Sc. degree program in Information and Software Engineering with close ties to the Humanities. The degree program was established on three cornerstones: 1) the ability to implement IT systems…