Search results for "CD"

ICT demand behaviour: An international comparison

2009

This study aims to provide some empirical explanations for the gaps in ICT diffusion between industrialized countries, especially European countries vis-à-vis the United States. The panel data cover eleven OECD countries: Austria, Denmark, Finland, France, Germany, Italy, Japan, the Netherlands, Spain, the United Kingdom and the United States. These annual macroeconomic data span the 1981-2005 period.The analysis provides some original results: (i) the impact on ICT diffusion of the level of education and market rigidities has changed over time. The correlation of ICT diffusion, positive with the level of education and negative with market rigidities, increased over time (in absolute terms)…

S-ICD implantācijas rezultāti Latvijā

2022

S-ICD ir jauna alternatīva TV-ICD metodei, kas tiek implantēta pēkšņas kardiālās nāves profilakses nolūkos un atšķirībā no TV-ICD lokalizējas pilnīgi ekstrakardiāli, novēršot vairākas ar transvenozu implantāciju saistītas komplikācijas. Pētījuma mērķis ir salīdzināt S-ICD un TV-ICD implantāciju un tās rezultātus Latvijā, sākot no 2018. gada. S-ICD grupas pacientiem novērots īsāks QRS komplekss, biežāk implantācija veikta sekundārās profilakses nolūkos, izmantojot vispārējo anestēziju, salīdzinot ar TV-ICD grupu. Kā arī, S-ICD grupā nav novērots lielāks komplikāciju un neadekvātu šoku skaits, nav novērota sliktāka dzīvību apdraudošu sirds ritma traucējumu (VT/VF) atpazīšanas funkcija, salīdz…

Atbalsta pasākumi sievietēm ar psihoemocionāla stāvokļa izmaiņām vēlīnā pēcdzemdību periodā

2017

Bakalaura darba tēma ir “Atbalsta pasākumi sievietēm ar psihoemocionāla stāvokļa izmaiņām vēlīnā pēcdzemdību periodā”. Pētījuma mērķis ir noskaidrot atbalsta pasākumus vēlīnā pēcdzemdību periodā sievietēm ar psihoemocionālām stāvokļa izmaiņām. Pētījuma uzdevumi ir izpētīt un izanalizēt zinātnisko literatūru par psihoemocionāliem traucējumiem pēcdzemdību periodā. Raksturot Betijas Ņūmenas (Betty Neuman) Slodzes samazināšanas toriju un saistīt to ar pētījuma tēmu, veikt pētījumu un intervēt respondentus, apstrādāt un izanalizēt iegūtos datus, izveidot secinājumus un priekšlikumus. Pētījuma jautājums - kādi ir atbalsta pasākumi sievietēm ar psihoemocionāla stāvokļa izmaiņām vēlīnā pēcdzemdību …

Minijet initial state of heavy-ion collisions from next-to-leading order perturbative QCD

2014

Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.

2003

International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

2002

In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…

Molecular Mechanisms of the Blockage of Glioblastoma Motility

2021

Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …

KOSMOS 2017 Peru Side Experiment: nutrients, phytoplankton abundances, enzyme rates, photophysiology

2022

This data was collected during an short-term incubation experiment in March 2017 that investigated the response of a surface plankton community to upwelling. This experiment was carried in the framework of the SFB754-funded KOSMOS mesocosm study that took place in La Punta, Callao, Peru between February-April 2017. A total of six different treatments were used to disentangle chemical and biological characteristics of deep water that influence surface plankton blooms: 2 different deep water sources with different nutrient concentrations; 3 treatments to distinguish the effects of inorganic nutrients, organic nutrients and deep water microbial populations. Measured variables include inorganic…

Análisis y Evaluación del tratamiento de la isquemia crítica de miembros inferiores no revascularizable mediante trasplante autólogo de progenitores …

2015

La enfermedad arterial periférica constituye una de las enfermedades con mayor impacto en la calidad de vida de los pacientes. La isquemia crítica de miembros inferiores es el estadio terminal de la enfermedad arterial periférica y presenta elevadas tasas de amputación de la extremidad a pesar del correcto tratamiento. En los últimos años, diversas publicaciones han mostrado efectos terapéuticos con el uso de células pluripotenciales obtenidas desde médula ósea en el tratamiento de la isquemia crítica sin opciones de revascularización, en lo que se ha llamado Angiogénesis Terapéutica. El objetivo de este estudio fue demostrar que, mediante el trasplante autólogo de progenitores hematopoyéti…

An Automatic Ontology-Based Approach to Support Logical Representation of Observable and Measurable Data for Healthy Lifestyle Management: Proof-of-C…

2020

Background Lifestyle diseases, because of adverse health behavior, are the foremost cause of death worldwide. An eCoach system may encourage individuals to lead a healthy lifestyle with early health risk prediction, personalized recommendation generation, and goal evaluation. Such an eCoach system needs to collect and transform distributed heterogenous health and wellness data into meaningful information to train an artificially intelligent health risk prediction model. However, it may produce a data compatibility dilemma. Our proposed eHealth ontology can increase interoperability between different heterogeneous networks, provide situation awareness, help in data integration, and discover…