Search results for "CD"
showing 10 items of 4072 documents
Limits on the production of the standard model Higgs boson in pp collisions at root s=7 TeV with the ATLAS detector
2011
A search for the Standard Model Higgs boson at the Large Hadron Collider (LHC) running at a centre-of-mass energy of 7 TeV is reported, based on a total integrated luminosity of up to 40 pb−1 collected by the ATLAS detector in 2010. Several Higgs boson decay channels: H→γγ, H→ZZ(∗)→ℓℓℓℓ, H→ZZ→ℓℓνν, H→ZZ→ℓℓqq, H→WW(∗)→ℓνℓν and H→WW→ℓνqq (ℓ is e, μ) are combined in a mass range from 110 GeV to 600 GeV. The highest sensitivity is achieved in the mass range between 160 GeV and 170 GeV, where the expected 95% CL exclusion sensitivity is at Higgs boson production cross sections 2.3 times the Standard Model prediction. Upper limits on the cross section for its production are determined. Models wit…
Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy
2019
The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and additionally, recent evidence shows that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary-open angle glaucoma patients (POAG) compared to healthy controls. Synthetically antibody-derived peptides can modulate various effector functions of the immune system and act as antimicrobial or antiviral molecules. In an ex vivo adolescent glaucoma model, this study, for the first time, demonstrates that polyclonal-derived complementarity-determining regions (CDRs) can significantly increase the survival rate …
Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial
2021
Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…
Identification and expansion of human colon-cancer-initiating cells
2007
Colon carcinoma is the second most common cause of death from cancer. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance, this has not been explored for colorectal cancer. Here, we show that tumorigenic cells in colon cancer are included in the high-density CD133+ population, which accounts for about 2.5% of the tumour cells. Subcutaneous injection of colon cancer CD133+ cells readily reproduced the original tumour in immunodeficient mice, whereas CD133- cells did not form …
Heavy flavour decay muon production at forward rapidity in proton--proton collisions at sqrt(s) = 7 TeV
2012
The production of muons from heavy flavour decays is measured at forward rapidity in proton-proton collisions at $\sqrt{s} = 7$ TeV collected with the ALICE experiment at the LHC. The analysis is carried out on a data sample corresponding to an integrated luminosity $L_{\rm int} = 16.5$ nb$^{-1}$. The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are measured in the rapidity range 2.5 < y < 4, over the transverse momentum range 2 < $p_{\rm T}$ < 12 GeV/$c$. The results are compared to predictions based on perturbative QCD calculations.
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Inactivation of peroxisomal ABC transporters, ABCD1 and ABCD2 in BV-2 microglial cells : Towards a better understanding of X-linked adrenoleukodystro…
2018
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder characterized by very-long-chain fatty acid (VLCFA) accumulation resulting from a peroxisomal β-oxidation defect. The disease is caused by mutations in the ABCD1 gene, which encodes for a peroxisomal half ABC transporter predicted, like its closest homologue ABCD2, to participate in the entry of VLCFA-CoA into the peroxisome, the unique site of their β-oxidation. Progress in understanding the physiopathogenesis of X-ALD suffers from the lack of appropriate cell and animal models. Since peroxisomal defects in microglia seem to be a key element of the onset of the disease, we generated four microglial cell lines unab…
International workshop on next generation gamma-ray source
2022
Journal of physics / G 49(1), 010502 (2022). doi:10.1088/1361-6471/ac2827
1992 o del equívoco europeo
1989
El cine detectivesco de Cifesa a través de sus personajes
2020
espanolEl cine espanol tiene como referente fundamental en su historia a la productora valenciana Cifesa. Su produccion se caracterizo por una fuerte apuesta por contenidos costumbristas, en ocasiones de corte folclorico, asi como por enaltecer los valores patrios a traves de peliculas de corte historico. La presente investigacion ahonda en un determinado sector de obras de corte detectivesco, las cuales supusieron pequenas rarezas en la produccion de la compania. Las peliculas fueron cuatro: El 13-13, Eloisa esta debajo de un almendro, La culpa del otro y El Clavo. Para entender cuales son los modelos de representacion del cine detectivesco en Cifesa, se analizaran los personajes a traves …