Search results for "CDP"

showing 4 items of 4 documents

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Uz čipu balstītās multiplex digitālās PĶR kvantifikācijas metodes novērtējums un verifikācija ĢMO testēšanas jomā.

2021

Digitālā polimerāzes ķēdes reakcija (dPĶR) ir kvantitatīva metode, kas var tikt ieviesta ĢMO testēšanas jomā, konkrētos gadījumos, aizstājot kvantitatīvo rlPĶR. Šī darba mērķis ir dPĶR metodi verificēt veicot salīdzinošu pētījumu ar sertificētiem ĢMO standarta materiāliem (CRM), lai novērtētu uz nodalījumiem balstītas dPĶR (cdPĶR) metodes veiktspēju un piemērotību ikdienas ĢMO testēšanā BIOR laboratorijā. Darbā izmantoti CRM ĢM notikumiem MON40-3-2 un MON810, kā arī dzīvnieku barības un Latvijas tautsaimniecībā aktuāli produkti klasisko ĢMO ekspozīcijas novērtējumam. Darba ietvarā veikts ĢMO skrīnings, kvantifikācija ar rlPĶR un dPĶR un izpildīts verifikācijas process. Metodes verifikācijas…

dPĶRcdPĶRmetodes verifikācijaBioloģijaĢMO
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First-principles LCAO study of the low and room temperature phases of CdPS$_3$

2020

A.K. is grateful to the Latvian Council of Science project no. lzp-2018/2-0353 for financial support. Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2.

Materials sciencePhysics and Astronomy (miscellaneous)Band gapfirst principles calculationsHydrostatic pressurelayered compoundGeneral Physics and AstronomyFOS: Physical sciencesCdPS3Electronic structure01 natural sciences7. Clean energyPressure rangePhase (matter)0103 physical sciences:NATURAL SCIENCES:Physics [Research Subject Categories]010306 general physics010302 applied physicsCondensed Matter - Materials ScienceCondensed matter physicsMaterials Science (cond-mat.mtrl-sci)electronic structurehigh pressureLinear combination of atomic orbitalsDirect and indirect band gapsMonoclinic crystal system
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Calcareous nannofossil events in the Lower-Mildle Pleistocene transition at the Montalbano Jonico section and ODP site 964: Calibration with isotope …

2004

We present quantitative data on calcareous nannofossil biostratigraphy in the section of Montalbano Jonico (Southern Italy). This is one of the candidate Global Statotype Section and Point (GSSP) of the Middle Pleistocene. The first common occurrence (FCO) and last common occurrence (LCO) of Reticulofenestra asanoi are well detectable in the section and are here proposed as additional events for improving biostratigraphic resolution in the interval corresponding to the transition between the small Gephyrocapsa Zone and Pseudoemiliania lacunosa Zone. The potential value of the bioevents is tested in a Mediterranean deep-sea core of ODP Site 964, located in the Ionian Sea. At Site 964 the FCO…

lcsh:GeologyCDPsealcsh:Paleontologysouthern Italylower-middle pleistocenelcsh:QE1-996.5quantitative biostratigraphybiochronologycalcareous nannofossitlcsh:QE701-760Ionian
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